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Journals / SDÜ Tıp Fakültesi Dergisi / 2026 / Cilt: 30 Sayı: 3

CAN PROSTATE-SPECIFIC MEMBRANE ANTIGENE TAKE PART IN MENENGIOMA TREATMENT?

PROSTAT-SPESİFİK MEMBRAN ANTİGEN MENENGİOM TEDAVİSİNDE YER ALABİLİR Mİ?

Ali Serdar Oğuzoğlu(SÜLEYMAN DEMİREL ÜNİVERSİTESİ)0000-0002-1735-4062
Nilgün Şenol(SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-1714-3150
Hasan Yasan(SÜLEYMAN DEMİREL ÜNİVERSİTESİ)0000-0002-5470-6784
Ramazan Oğuz Yüceer(SÜLEYMAN DEMİREL ÜNİVERSİTESİ)0000-0002-9418-8862
İbrahim Metin Çiriş(SÜLEYMAN DEMİREL ÜNİVERSİTESİ)0000-0002-5619-4989
Pages
302–307
Publication Date
2023-09-23
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Although no significant results were achieved in terms of PSMA, as the molecular and genetic techniques progress, tumor biology manifestation and determination of potential targets will lead to new treatment procedures.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective In tumor development, tumor angiogenesis is an essential component, and a valuable marker in the differantial diagnosis of brain tumors.
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Key Findings & Data:Material and Method Pathologic specimens with the diagnosis Grade I (n=32), Grade II (n=6) ve Grade III (n=10) of 48 patients operated for menengioma in our clinic, were evaluated for PSMA-antibody via immunohistochemical method.
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Conclusion & Impact:Although no significant results were achieved in terms of PSMA, as the molecular and genetic techniques progress, tumor biology manifestation and determination of potential targets will lead to new treatment procedures.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:menengiom · antijen · prostat-spesifik membran

Abstract

Objective In tumor development, tumor angiogenesis is an essential component, and a valuable marker in the differantial diagnosis of brain tumors. As menengiomas are highly vascular tumors in this study, we aimed to evaluate the expression of prostate-spesific membrane antigen (PSMA) in menengiomas by immunohistochemistry method to determine different target therapies. Material and Method Pathologic specimens with the diagnosis Grade I (n=32), Grade II (n=6) ve Grade III (n=10) of 48 patients operated for menengioma in our clinic, were evaluated for PSMA-antibody via immunohistochemical method. PSMA staining intensities in tumor tissue and tumor epithelium were analyzed. Vascular expression in tumoral and extratumoral stroma, and intensity score, according to PSMA expression, in tumoral epithelium were analyzed. Results Immunohistochemical analyses of different grade menengioma specimens showed no statistically significant differences between PSMA expression and PSMA staining intensities in tumor tissue and tumor epithelium (p>0.05). Conclusion Some molecular biomarkers, that take part in angiogenesis of agressive and unresectable menengiomas come into prominence. Although no significant results were achieved in terms of PSMA, as the molecular and genetic techniques progress, tumor biology manifestation and determination of potential targets will lead to new treatment procedures.

Özet

Amaç Tümör oluşumunda ve ayırıcı tanısında tümör anjiogenezi önemli bir unsur ve değerli bir göstergedir. Menengiomlar vasküleritesi yüksek tümörler olması nedeni ile bu çalışmada, farklı tedavi protokollerinin geliştirilebilmesi açısından menengiomlarda immunohistokimyasal yöntemlerle prostat-spesifik membran antijen (PSMA) salınımının değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem Kliniğimizde opere edilerek Derece I (n=32), Derece II (n=6) ve Derece III (n=10) menengiom tanısı almış 48 hastadan alınmış olan doku örneklerinde PSMA antikorları immunohistokimyasal metod ile incelendi. Tümör dokusundaki PSMA boyanma yoğunluğu ve yüzdesi incelendi. Tümör epitelinde tümör ve tümör-dışı dokuda PSMA salınımına göre vasküler salınım ve yoğunluk skoru analiz edildi. Bulgular Farklı derecelerdeki menengiom preparatlarında yapılan immunohistokimyasal analizler tümör epitelinde ve stromasında PSMA salınım ve yoğunluk skorları arasında istatistiksel olarak anlamlı farklılık olmadığını gösterdi (p>0.05). Sonuç Agresif seyreden, rezeke edilemeyen menegiomlarda anjiogeneziste rol alan bazı moleküler biomarkerlar önem kazanmaktadır. Her ne kadar PSMA açısından anlamlı sonuçlar elde edilmemiş olsa da moleküler ve genetik teknikler geliştikçe tümör biyolojisinin ortaya konup potansiyel hedeflerin belirlenmesi yeni tedavi yolları açacaktır.

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Cite This Article

Oğuzoğlu, A. S., Şenol, N., Yasan, H., Yüceer, R. O., Çiriş, İ. M. (2023). CAN PROSTATE-SPECIFIC MEMBRANE ANTIGENE TAKE PART IN MENENGIOMA TREATMENT?. SDÜ Tıp Fakültesi Dergisi, Cilt: 30 Sayı: 3, 302–307. https://doi.org/10.17343/sdutfd.1209482

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