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Journals / SDÜ Tıp Fakültesi Dergisi / 2026 / Cilt: 31 Sayı: 2

The Impact of Salubrinal in Preventing Fetal Brain Damage in a Model of Chorioamnionitis Induced by LPS

Pelin İçten(SULEYMAN DEMIREL UNIVERSITY)0000-0002-7933-0883
Songül Özkula(SULEYMAN DEMIREL UNIVERSITY)0000-0003-4977-2784
Mehtap Savran(SULEYMAN DEMIREL UNIVERSITY)0000-0002-7933-0453
Kanat Gülle(SULEYMAN DEMIREL UNIVERSITY)0000-0002-6337-8962
Yalcin Erzurumlu(SULEYMAN DEMIREL UNIVERSITY)0000-0001-6835-4436
Nasıf Fatih Karakuyu(SULEYMAN DEMIREL UNIVERSITY, FACULTY OF PHARMACY)0000-0002-2249-4668
Mekin Sezik(SULEYMAN DEMIREL UNIVERSITY)0000-0002-6989-081X
Halil Aşçı(SULEYMAN DEMIREL UNIVERSITY)0000-0002-1545-035X
Pages
159–165
Publication Date
2024-06-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: As a result; ER stress is one of the mechanisms that play a role in placental tissue and fetal brain damage due to CRY, and SLB therapy might prevent this damage.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Chorioamnionitis (CRY), with membrane rupture, preterm labor, prolonged labor, smoking, and bacterial or viral infection origin; is a condition that presents a risk for both maternal and neonatal sequelae.
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Key Findings & Data:Material and Method: In this study, 24 Wistar Albino rats on the 17th gestational day; were divided into 4 groups; control, LPS (1 mg/kg intraperitoneal (ip)), LPS + SLB (1 mg/kg LPS ip and 1 mg/kg SLB ip) and SLB (1 mg/kg ip).
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Conclusion & Impact:Conclusion: As a result; ER stress is one of the mechanisms that play a role in placental tissue and fetal brain damage due to CRY, and SLB therapy might prevent this damage.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Chorioamnionitis · Endoplasmic reticulum stress · Lipopolysaccharide

Abstract

Objective: Chorioamnionitis (CRY), with membrane rupture, preterm labor, prolonged labor, smoking, and bacterial or viral infection origin; is a condition that presents a risk for both maternal and neonatal sequelae. Our study aimed to investigate the effect of Salubrinal (SLB), an endoplasmic reticulum (ER) stress inhibitor, against damage to placental tissue and fetal brain in the Lipopolysaccharide (LPS) induced CRY model. Material and Method: In this study, 24 Wistar Albino rats on the 17th gestational day; were divided into 4 groups; control, LPS (1 mg/kg intraperitoneal (ip)), LPS + SLB (1 mg/kg LPS ip and 1 mg/kg SLB ip) and SLB (1 mg/kg ip). After an experimental hysterectomy, the placenta and fetal brain tissues were taken into formaldehyde solution for histopathological analysis. Results: According to the findings obtained; widespread congestion in the basal zone, degeneration of trophoblastic cells in the labyrinth zone, and inflammatory cell infiltrations in both basal and labyrinth zones were observed in the placental tissues of the LPS group. No pathology was detected in only the SLB group. While edema and congestion were detected in the ventricular and intermediate zones in the fetal brain tissues of the LPS group, a significant improvement was observed in these findings with SLB treatment. Conclusion: As a result; ER stress is one of the mechanisms that play a role in placental tissue and fetal brain damage due to CRY, and SLB therapy might prevent this damage.

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Cite This Article

İçten, P., Özkula, S., Savran, M., Gülle, K., Erzurumlu, Y., Karakuyu, N. F., Sezik, M., Aşçı, H. (2024). The Impact of Salubrinal in Preventing Fetal Brain Damage in a Model of Chorioamnionitis Induced by LPS. SDÜ Tıp Fakültesi Dergisi, Cilt: 31 Sayı: 2, 159–165. https://doi.org/10.17343/sdutfd.1445673

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