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Journals / SDÜ Tıp Fakültesi Dergisi / 2026 / Cilt: 31 Sayı: 3

The Relationship Between Hematological Inflammatory Markers and Postoperative Hypocalcemia in Patients with Primary Hyperparathyroidism

Primer Hiperparatiroidi Tanılı Hastalarda Hematolojik İnflamatuar Belirteçler ile Postoperatif Hipokalsemi Arasındaki İlişki

Emre Gezer(KOCAELI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES)0000-0002-5340-6106
Ömer Zekey(KOCAELI UNIVERSITY, SCHOOL OF MEDICINE)0009-0004-4142-3605
Büşra Yaprak Bayrak(KOCAELI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF PATHOLOGY)0000-0002-0537-3127
Zeynep Cantürk(KOCAELI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES)0000-0001-7114-2565
Berrin Çetinarslan(KOCAELI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES)0000-0002-8041-8161
Alev Selek(KOCAELI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES)0000-0002-0646-8697
Mehmet Sözen(KOCAELI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES)0000-0002-8428-1115
Damla Köksalan(KOCAELI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES)0000-0002-6349-2976
Pages
205–211
Publication Date
2024-09-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Keywords: Hyperparathyroidism, Hypocalcemia, Neutrophils, Lymphocytes, Platelets

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Primary hyperparathyroidism (PHPT) is a common endocrine disease that is characterized by hypercalcemia and commonly associated with parathyroid adenoma (PTA).
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Key Findings & Data:Results: NLR was significantly correlated with parathormone (PTH), while PLR was related considerably with only NLR.
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Conclusion & Impact:Keywords: Hyperparathyroidism, Hypocalcemia, Neutrophils, Lymphocytes, Platelets
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Hiperparatiroidizm · Hipokalsemi · Nötrofiller

Abstract

Objective: Primary hyperparathyroidism (PHPT) is a common endocrine disease that is characterized by hypercalcemia and commonly associated with parathyroid adenoma (PTA). Hypocalcemia is a common postoperative complication in patients with PHPT. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are inexpensive hematological inflammatory markers. We aimed to investigate the potential predictive risk factors, including the hemogram-derived inflammatory markers for early postoperative hypocalcemia in patients with PHPT. Material and Method: Patients diagnosed with PHPT, underwent parathyroidectomy and histopathologically shown to be caused by a single PTA were included. Results: NLR was significantly correlated with parathormone (PTH), while PLR was related considerably with only NLR. A significant positive correlation was shown between gland weight, volume, calcium (Ca), and PTH levels. A significant correlation of postoperative hypocalcemia with age, preoperative Ca, PTH, and NLR was also demonstrated. Conclusion: We found that NLR was significantly higher in patients with PHPT who developed postoperative hypocalcemia; however, our regression analysis did not find elevated NLR as a significant predictive risk factor for postoperative hypocalcemia. To the best of our knowledge, this is the first study investigating the relationship between hemogram-derived inflammatory markers and clinical parameters, such as the development of postoperative hypocalcemia and preoperative nephrolithiasis, in patients with PHPT. Keywords: Hyperparathyroidism, Hypocalcemia, Neutrophils, Lymphocytes, Platelets

Özet

Amaç: Primer hiperparatiroidizm (PHPT), hiperkalsemi ile karakterize olan ve sıklıkla paratiroid adenomu (PTA) ile ilişkili yaygın bir endokrin hastalığıdır. Hipokalsemi PHPT'li hastalarda sık görülen bir postoperatif komplikasyondur. Nötrofil-lenfosit oranı (NLR) ve platelet-lenfosit oranı (PLR) ucuz hematolojik inflamatuar belirteçlerdir. PHPT'li hastalarda erken postoperatif hipokalsemi için hemogramdan türetilmiş inflamatuar belirteçler dahil olmak üzere potansiyel prediktif risk faktörlerini araştırmayı amaçladık. Gereç ve Yöntem: PHPT tanısı alan, paratiroidektomi uygulanan ve histopatolojik olarak tek PTA’dan kaynaklandığı gösterilen hastalar çalışmaya dahil edildi. Bulgular: NLR, parathormon (PTH) ile, PLR ise sadece NLR ile anlamlı düzeyde ilişkiliydi. Gland ağırlığı ve hacmi ile kalsiyum (Ca) ve PTH düzeyleri arasında anlamlı pozitif korelasyon gösterildi. Postoperatif hipokalseminin yaş, ameliyat öncesi Ca, PTH ve NLR ile anlamlı bir korelasyonu da gösterilmiştir. Sonuç: Postoperatif hipokalsemi gelişen PHPT'li hastalarda NLR'nin anlamlı derecede yüksek olduğunu bulduk; ancak regresyon analizimizde yüksek NLR'nun postoperatif hipokalsemi için anlamlı bir prediktif risk faktörü olmadığı gösterildi. Bildiğimiz kadarıyla bu, PHPT'li hastalarda hemogramdan türetilen inflamatuar belirteçler ile postoperatif hipokalsemi gelişimi ve preoperatif nefrolitiazis varlığı gibi klinik parametreler arasındaki ilişkiyi araştıran ilk çalışmadır.

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Cite This Article

Gezer, E., Zekey, Ö., Bayrak, B. Y., Cantürk, Z., Çetinarslan, B., Selek, A., Sözen, M., Köksalan, D. (2024). The Relationship Between Hematological Inflammatory Markers and Postoperative Hypocalcemia in Patients with Primary Hyperparathyroidism. SDÜ Tıp Fakültesi Dergisi, Cilt: 31 Sayı: 3, 205–211. https://doi.org/10.17343/sdutfd.1413088

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