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Journals / SDÜ Tıp Fakültesi Dergisi / 2024 / Cilt: 31 Sayı: 4

The Protective Effects of Cannabidiol on Chest Trauma-Induced Brain Injury by its Antioxidant and Anti-Inflammatory Effects

Adem Milletsever(BURDUR MEHMET AKİF ERSOY ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ, PATOLOJİ (DR) (VETERİNER))0000-0002-3614-7798
Abdurrahman Gülal(SÜLEYMAN DEMİREL ÜNİVERSİTESİ)0009-0007-1743-412X
Halil Aşçı(SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-1545-035X
Pages
332–338
Publication Date
2024-12-26
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These damages can be corrected with CBD treatment.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Chest trauma-induced brain injury (CTBI) is caused by the formation of inflammatory cytokines in the lungs and blood.
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Key Findings & Data:Material and Method: Forty male Wistar Albino rats were divided into four groups: control, CTBI (200 g weight drop on the anterior chest wall from a height of 1 meter), CTBI+CBD (5 mg/kg, single dose intraperitoneally), and CBD.
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Conclusion & Impact:These damages can be corrected with CBD treatment.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Blunt chest trauma · brain · cannabidiol

Abstract

Objective: Chest trauma-induced brain injury (CTBI) is caused by the formation of inflammatory cytokines in the lungs and blood. Cannabidiol (CBD), a non-psychoactive agent, has antioxidant, anti-inflammatory, and antiapoptotic properties. In this study, we aimed to investigate the protective effects of CBD on CTBI. Material and Method: Forty male Wistar Albino rats were divided into four groups: control, CTBI (200 g weight drop on the anterior chest wall from a height of 1 meter), CTBI+CBD (5 mg/kg, single dose intraperitoneally), and CBD. After 48 hours, rats were sacrificed under anesthesia, and brain tissues were placed in a 10% formaldehyde solution for histopathological and immunohistochemical examination. Results: In the CTBI group, hemorrhagic areas, tumor necrosis factor-alpha, caspase-3, and malondialdehyde expressions increased in histological and immunohistochemical examinations compared to the control group. CBD treatment reduced hemorrhagic areas and reversed immune expressions. Conclusion: Inflammation, apoptosis, and oxidative stress in brain tissue may develop in CTBI. These damages can be corrected with CBD treatment.

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Cite This Article

Milletsever, A., Gülal, A., Aşçı, H. (2024). The Protective Effects of Cannabidiol on Chest Trauma-Induced Brain Injury by its Antioxidant and Anti-Inflammatory Effects. SDÜ Tıp Fakültesi Dergisi, Cilt: 31 Sayı: 4, 332–338. https://doi.org/10.17343/sdutfd.1514644

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