Journals / Sağlık Profesyonelleri Araştırma Dergisi / 2026 / Sayı: 2026

Polycystic Ovary Syndrome (PCOS): A Review of Nutritional Approaches, Supplements, and Natural Therapies

Polikistik Over Sendromu: Beslenme Yaklaşımları, Takviyeler ve Doğal Terapiler Üzerine Bir Derleme

Fatma Şule Bilgiç(CANAKKALE ONSEKIZ MART UNIVERSITY)0000-0002-5950-2553
Pages
36–42
Publication Date
2026-02-18
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, studies have reported that special nutritional models such as the Mediterranean diet, high-protein diets and ketogenic diet have positive effects on metabolic and hormonal parameters.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in young women of reproductive age.
📊
Key Findings & Data:It is known that PCOS, which is frequently associated with obesity, is characterized by Type 2 diabetes, lipid profile disorders and increased androgen production due to the presence of insulin resistance.
💡
Conclusion & Impact:In conclusion, studies have reported that special nutritional models such as the Mediterranean diet, high-protein diets and ketogenic diet have positive effects on metabolic and hormonal parameters.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Polikistik over sendromu · abdominal obezite · hiperandrojenizim

Abstract

Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in young women of reproductive age. This review is to compile the current literature and studies on current nutritional approaches, supplements, and natural therapies in PCOS. The exact cause of PCOS, which develops under strong epigenetic and environmental influences including nutrition and lifestyle factors, is not yet known. It is known that PCOS, which is frequently associated with obesity, is characterized by Type 2 diabetes, lipid profile disorders and increased androgen production due to the presence of insulin resistance. This review compiles the studies and the current literature on current nutritional approaches, supplements and natural therapies in PCOS. In conclusion, studies have reported that special nutritional models such as the Mediterranean diet, high-protein diets and ketogenic diet have positive effects on metabolic and hormonal parameters. In addition, natural therapies such as inositol, N-acetyl cysteine and peppermint tea provide significant support for symptom management.

Özet

Polikistik Over Sendromu (PKOS), üreme çağındaki genç kadınlarda en sık görülen endokrin bozukluktur. Bu derleme, PKOS’da güncel beslenme yaklaşımları, takviyeler ve doğal terapiler üzerine yapılan çalışmaları ve mevcut literatürü derlemektir. Beslenme ve yaşam tarzı faktörleri de dahil olmak üzere güçlü epigenetik ve çevresel etkilerin altında gelişen PKOS’un kesin nedeni henüz bilinmemektedir. Sıklıkla obezite ile ilişkilendirilen PKOS’un, insülin direncinin varlığı nedeniyle Tip 2 diyabet, lipid profil bozuklukları ve artmış androjen üretimi ile karakterize olarak seyrettiği bilinmektedir. Bu derleme, PKOS’da güncel beslenme yaklaşımları, takviyeler ve doğal terapiler üzerine yapılan çalışmaları ve mevcut literatürü derlemektir. Sonuç olarak Akdeniz diyeti, yüksek proteinli diyetler ve ketojenik diyet gibi özel beslenme modelleri, metabolik ve hormonal parametreler üzerinde olumlu etkiler gösterdiği çalışmalarca bildirilmiştir. Ayrıca, inositol, N-asetil sistein ve nane çayı gibi doğal terapiler, semptom yönetimine önemli bir destek sunmaktadır.

🔖

Cite This Article

Bilgiç, F. Ş., Karaahmet, A. Y. (2026). Polycystic Ovary Syndrome (PCOS): A Review of Nutritional Approaches, Supplements, and Natural Therapies. Sağlık Profesyonelleri Araştırma Dergisi, Sayı: 2026, 36–42. https://doi.org/10.57224/jhpr.1659947

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (37)

  1. Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14(5):270–84.
  2. Dapas M, Dunaif A. Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification. Endocr Rev. 2022;43(6):927–65.
  3. De Leo V, Musacchio MC, Cappelli V, Massaro MG, Morgante G, Petraglia F. Genetic, hormonal and metabolic aspects of PCOS: an update. Reprod Biol Endocrinol. 2016;14(1):2–17.
  4. Calcaterra V, Verduci E, Cena H, Magenes VC, Todisco CF, Tenuta E, et al. Polycystic ovary syndrome in insulin-resistant adolescents with obesity: The role of nutrition therapy and food supplements as a strategy to protect fertility. Nutrients. 2021;13(6):1848.
  5. Day F, Karaderi T, Jones MR, Meun C, He C, et al. Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria. PLoS Genet. 2018;14(12):e1007813.
  6. Moslehi N, Zeraattalab-Motlagh S, Rahimi Sakak F, Shab-Bidar S, Tehrani FR, Mirmiran P. Effects of nutrition on metabolic and endocrine outcomes in women with polycystic ovary syndrome: An umbrella review of meta-analyses of randomized controlled trials. Nutr Rev. 2023;81(5):555–77.
  7. Szczuko M, Kikut J, Szczuko U, Szydłowska I, Nawrocka-Rutkowska J, Ziętek M, et al. Nutrition strategy and life style in polycystic ovary syndrome—narrative review. Nutrients. 2021;13(7):2452.
  8. Ashkar F, Rezaei S, Salahshoornezhad S, Vahid F, Gholamalizadeh M, Dahka SM, et al. The role of medicinal herbs in treatment of insulin resistance in patients with polycystic ovary syndrome: A literature review. Biomol Concepts. 2020;11(1):57–75.
  9. Ateeq A. Androgen modulation through spearmint tea: Exploring effects in PKOS and non-PKOS populations. J Acad Nutr Diet. 2024;124(10):A26.
  10. Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, et al. Inositol is an effective and safe treatment in polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Reprod Biol Endocrinol. 2023;21(1):10.
  11. Amisi CA. Markers of insulin resistance in polycystic ovary syndrome women: An update. World J Diabetes. 2022;13(3):129.
  12. Kicińska AM, Maksym RB, Zabielska-Kaczorowska MA, Stachowska A, Babińska A. Immunological and metabolic causes of infertility in polycystic ovary syndrome. Biomedicines. 2023;11(6):1567.
  13. Stubert J, Reister F, Hartmann S, Janni W. The risks associated with obesity in pregnancy. Dtsch Arztebl Int. 2018;115(16):276.
  14. Haase CL, Varbo A, Laursen PN, Schnecke V, Balen AH. Association between body mass index, weight loss and the chance of pregnancy in women with polycystic ovary syndrome and overweight or obesity: A retrospective cohort study in the UK. Hum Reprod. 2023;38(3):471–81.
  15. Spritzer PM, Marchesan LB, Santos BR, Fighera TM. Hirsutism, normal androgens and diagnosis of PCOS. Diagnostics. 2022;12(8):1922.
  16. Lumezi BG, Berisha VL. Investigation of body mass index, insulin resistance and diabetes in patients with hirsutism. Adv Dermatol Allergol. 2021;38(6):1006–10.
  17. Mansour A, Mirahmad M, Mohajeri-Tehrani MR, Jamalizadeh M, Hosseinimousa S, Rashidi F, et al. Risk factors for insulin resistance related to polycystic ovarian syndrome in Iranian population. Sci Rep. 2023;13(1):10269.
  18. Barrea L, Arnone A, Annunziata G, Muscogiuri G, Laudisio D, Salzano C, et al. Adherence to the Mediterranean diet, dietary patterns and body composition in women with polycystic ovary syndrome (PCOS). Nutrients. 2019;11(10):2278.
  19. Wang F, Dou P, Wei W, Liu PJ. Effects of high-protein diets on the cardiometabolic factors and reproductive hormones of women with polycystic ovary syndrome: A systematic review and meta-analysis. Nutr Diabetes. 2024;14(6):1–11.
  20. Paoli A, Mancin L, Giacona MC, Bianco A, Caprio M. Effects of a ketogenic diet in overweight women with polycystic ovary syndrome. J Transl Med. 2020;18(1):104.
  21. Mei S, Ding J, Wang K, Ni Z, Yu J. Mediterranean diet combined with a low-carbohydrate dietary pattern in the treatment of overweight polycystic ovary syndrome patients. Front Nutr. 2022;9:876620.
  22. Foscolou A, Papandreou P, Gioxari A, Skouroliakou M. Optimizing dietary habits in adolescents with polycystic ovary syndrome: Personalized Mediterranean diet intervention via clinical decision support system—a randomized controlled trial. Children (Basel). 2024;11(6):635.
  23. Deshmukh H, Papageorgiou M, Wells L, Akbar S, Strudwick T, Deshmukh K, et al. The effect of a very-low-calorie diet (VLCD) vs. a moderate energy deficit diet in obese women with polycystic ovary syndrome (PCOS)—A randomised controlled trial. Nutrients. 2023;15(18):3872.
  24. Kazemi M, Hadi A, Pierson RA, Lujan ME, Zello GA, Chilibeck PD. Effects of dietary glycemic index and glycemic load on cardiometabolic and reproductive profiles in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Adv Nutr. 2021;12(1):161–78.
  25. Hoover SE, Gower BA, Cedillo YE, Chandler-Laney PC, Deemer SE, Goss AM. Changes in ghrelin and glucagon following a low glycemic load diet in women with PCOS. J Clin Endocrinol Metab. 2021;106(5):e2151–e2161.
  26. Chi Y, Yue R, Lv Y, Li H, Liao W. The dietary phytochemical index and its relation to polycystic ovary syndrome: A case-control study. J Ovarian Res. 2024;17(1):228.
  27. González F, Considine RV, Abdelhadi OA, Acton AJ. Saturated fat ingestion promotes lipopolysaccharide-mediated inflammation and insulin resistance in polycystic ovary syndrome. J Clin Endocrinol Metab. 2019;104(3):934–46.
  28. Dou P, Zhang TT, Xu Y, Shang J, Lang XL, Xue Q. Effects of three medical nutrition therapies for weight loss on metabolic parameters and androgen level in overweight/obese patients with polycystic ovary syndrome. Zhonghua Yi Xue Za Zhi. 2023;103(14):1035–41.
  29. Sørensen LB, Søe M, Halkier KH, Stigsby B, Astrup A. Effects of increased dietary protein-to-carbohydrate ratios in women with polycystic ovary syndrome. Am J Clin Nutr. 2012;95(1):39–48.
  30. Ainehchi N, Khaki A, Farshbaf-Khalili A, Hammadeh M, Ouladsahebmadarek E. The effectiveness of herbal mixture supplements with and without clomiphene citrate in comparison to clomiphene citrate on serum antioxidants and glycemic biomarkers in women with polycystic ovary syndrome willing to be pregnant: A randomized clinical trial. Biomolecules. 2019;9(6):215.
  31. Malakhed S. Molecular docking of spearmint phytocompounds against CYP21A2: Implications for PKOS therapy. Innovare J Med Sci. 2024:1–8.
  32. Fitz V, Graca S, Mahalingaiah S, Liu J, Lai L, Butt A, et al. Inositol for polycystic ovary syndrome: A systematic review and meta-analysis to inform the 2023 update of the international evidence-based PKOS guidelines. J Clin Endocrinol Metab. 2024;109(6):1630–55.
  33. Song Y, Wang H, Huang H, Zhu Z. Comparison of the efficacy between NAC and metformin in treating PKOS patients: A meta-analysis. Gynecol Endocrinol. 2020;36(3):204–10.
  34. Huang Y, Zhang X. Meta-analysis of the efficacy of ω-3 polyunsaturated fatty acids when treating patients with polycystic ovary syndrome. Medicine. 2023;102(39):e35403.
  35. Jaripur M, Ghasemi-Tehrani H, Askari G, Gholizadeh-Moghaddam M, Clark CCT, Rouhani MH. The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: A randomized clinical trial. Reprod Biol Endocrinol. 2022;20(1):110.
  36. Merviel P, James P, Bouée S, Le Guillou M, Rince C, Nachtergaele C, et al. Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies. Reprod Health. 2021;18(1):13.
  37. Yifu P. A review of antioxidant N-acetylcysteine in addressing polycystic ovary syndrome. Gynecol Endocrinol. 2024;40(1):2381498.