SavedAdd your journal

Journals / Cyprus Journal of Medical Sciences / 2019 / Cilt: 4 - Sayı: 2

Evaluation of Thyrotropin and Thyroxine Levels in The First Month of Life

Selma AKTAŞ
Pages
99–102
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION We demonstrated that the TSH and FT4 levels change during the neonatal period without a significant sex difference.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:BACKGROUND/AIMS Thyrotropin (TSH) and thyroxine (FT4) levels in neonates are not similar to those in older children and adults.
📊
Key Findings & Data:The aim of this study is to determine the TSH and FT4 hormone levels in newborns aged >37 gestational weeks.
💡
Conclusion & Impact:CONCLUSION We demonstrated that the TSH and FT4 levels change during the neonatal period without a significant sex difference.
🔬Design:Lab & Field Experiment
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

BACKGROUND/AIMS Thyrotropin (TSH) and thyroxine (FT4) levels in neonates are not similar to those in older children and adults. The aim of this study is to determine the TSH and FT4 hormone levels in newborns aged >37 gestational weeks. MATERIAL and METHODS The blood samples for TSH and FT4 obtained from newborns aged >37 gestational weeks were analyzed at postnatal 4-7, 8-14, 15-21, and 22-30 days and established as reference intervals for the first week of life, in addition to the mean and median levels for other observation points. RESULTS There was no significant difference according to gender, gestational age, and mode of delivery (p>0.05); therefore, a pooled analysis was performed. The lower and upper limits of the TSH and FT4 levels from the 4th to 7th day of life were 1.20-10.70 mIU/mL and 0.87-2.20 ng/dL, respectively. CONCLUSION We demonstrated that the TSH and FT4 levels change during the neonatal period without a significant sex difference.

🔖

Cite This Article

AKTAŞ, S. (2019). Evaluation of Thyrotropin and Thyroxine Levels in The First Month of Life. Cyprus Journal of Medical Sciences, Cilt: 4 - Sayı: 2, 99–102. https://ajindex.com/articles/153802

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (3)

  1. LaFranchi S. Disorders of the thyroid gland. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, editors. Nelson textbook of pediatrics. 18th ed. Philadelphia: Sounders Elsevier; 200; 2316-27
  2. Özön ZA. Congenital hypothyroidism monitorization programs, current status in Turkey Turkiye Klinikleri. J Endocrin Spec Top 2008; 1: 1-7
  3. Rose SR, Brown RS, Foley T, Kaplowitz PB, Kaye CI, Sundararajan S, et al. Update of newborn screening and therapy for congenital hypothyroidism. Pediatrics 2006; 117: 2290-303. [CrossRef] 4. Knobel RB. Thyroid hormone levels in term and preterm neonates. Neonatal Netw 2007; 26: 253-9. [CrossRef] 5. Mutlu M, Karagüzel G, Alıyazicioğlu Y, Eyüpoğlu I, Okten A, Aslan Y. Reference intervals for thyrotropin and thyroid hormones and ultrasonographic thyroid volume during the neonatal period. J Matern Fetal Neonatal Med 2012; 25: 120-4. [CrossRef] 6. Kawahara K, Yokoya S. Establishment of reference intervals of thyrotropin and free thyroid hormones during the first week of life. Clin Pediatr Endocrinol 2002; 11: 1-9. [CrossRef] 7. Imamoglu EY, Gursoy T, Hayran M, Karatekin G, Ovalı F. Nomogram-based evaluation of thyroid function in appropriate-for-gestational-age neonates in intensive care unit. J Perinatol 2015; 35: 204-7. [CrossRef] 8. Kapelari K, Kirchlechner C, Högler W, Schweitzer K, Virgolini I, Moncayo R. Pediatric reference intervals for thyroid hormone levels from birth to adulthood: a retrospective study. BMC Endocr Disord 2008; 8: 15. [CrossRef] 9. Kratzsch J, Schubert G, Pulzer F, Pfaeffle R, Koerner A, Dietz A, et al. Reference intervals for TSH and thyroid hormones are mainly affected by age, body mass index and number of blood leucocytes, but hardly by gender and thyroid autoantibodies during the first decades of life. Clin Biochem 2008; 41: 1091-98. [CrossRef] 10. Elmlinger MW, Kuhnel W, Lambrecht HG, Ranke MB. Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG) and thyrotropin (TSH). Clin Chem Lab Med 2001; 39: 973-9. [CrossRef] 11. Hubner U, Englisch C, Werkmann H, Butz H, Georgs T, Zabransky S, et al. Continuous age-dependent reference ranges for thyroid hormones in neonates, infants, children and adolescents established using the ADVIA Centaur Analyzer. Clin Chem Lab Med 2002; 40: 1040-7. [CrossRef] 12. Verburg FA, Kirchgässner C, Hebestreit H, Steigerwald U, Lentjes EG, Ergezinger K, et al. Reference Ranges for Analyt