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Journals / Pediatric Practice and Research / 2026 / Volume: 12 Issue: 2

Can Apigenin Be an Effective Therapeutic Agent Against Experimental Renal Ischemia-Reperfusion Injury?

Apigenin Deneysel Renal İskemi-Reperfüzyon Hasarına Karşı Etkili Bir Terapötik Ajan Olabilir mi?

Ömer Topdağı(BAHCESEHIR UNIVERSITY)0000-0002-9690-4447
Mustafa Can Güler(ATATURK UNIVERSITY)0000-0001-8588-1035
Ersen Eraslan(BANDIRMA ONYEDI EYLUL UNIVERSITY)0000-0003-2424-2269
Fazile Nur Ekinci Akdemir(AGRI IBRAHIM CECEN UNIVERSITY)0000-0001-9585-3169
Ayhan Tanyeli(ATATURK UNIVERSITY)0000-0002-0095-0917
Saime Özbek Şebin(ATATURK UNIVERSITY)0000-0002-1738-4800
Engin Şebin(UNIVERSITY OF HEALTH SCIENCES, ERZURUM REGION HEALTH RESEARCH CENTER)0000-0001-9150-8069
Pages
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Publication Date
2024-07-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Biochemical results showed that oxidative and inflammatory markers increased significantly in the R I/R group, but antioxidant activities decreased significantly.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: This study aims to reveal the effects of two doses of apigenin (API) against renal ischemia-reperfusion injury (R I/R).
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Key Findings & Data:Material and Methods: For this purpose, 5 and 10 mg/kg doses of API were preferred in our study, and the groups were designed as sham, R I/R, 5 mg/kg API, and 10 mg/kg API groups for the implementation of the experimental protocol.
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Conclusion & Impact:Results: Biochemical results showed that oxidative and inflammatory markers increased significantly in the R I/R group, but antioxidant activities decreased significantly.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Apigenin · kidney · ischemia/reperfusion.

Abstract

Aim: This study aims to reveal the effects of two doses of apigenin (API) against renal ischemia-reperfusion injury (R I/R). Material and Methods: For this purpose, 5 and 10 mg/kg doses of API were preferred in our study, and the groups were designed as sham, R I/R, 5 mg/kg API, and 10 mg/kg API groups for the implementation of the experimental protocol. In the R I/R model, 1-hour ischemia and 24-hour reperfusion periods were preferred. Oxidative and inflammatory markers were measured biochemically in samples taken at the end of the experiment. Results: Biochemical results showed that oxidative and inflammatory markers increased significantly in the R I/R group, but antioxidant activities decreased significantly. In the 5 and 10 mg/kg API groups, R I/R damage was alleviated considerably, with these markers approaching the sham group values. Conclusion: As a result, the study's results determined that two different doses of API were effective against R I/R-induced kidney damage.

Özet

Amaç: Bu çalışma, iki doz apigenin (API) kullanımının renal iskemi-reperfüzyon hasarına (R I/R) karşı etkilerini ortaya koymayı amaçlamaktadır. Gereç ve Yöntem: Bu amaçla çalışmamızda API'nin 5 ve 10 mg/kg dozları tercih edilmiş ve deneysel protokolün uygulanması için gruplar sham, R I/R, 5 mg/kg API ve 10 mg/kg API grupları olarak tasarlanmıştır. R I/R modelinde 1 saatlik iskemi ve 24 saatlik reperfüzyon periyotları tercih edilmiştir. Deney sonunda alınan örneklerde oksidatif ve inflamatuvar belirteçler biyokimyasal olarak ölçüldü. Bulgular: Biyokimyasal sonuçlar oksidatif ve inflamatuar belirteçlerin R I/R grubunda anlamlı olarak arttığını, ancak antioksidan aktivitelerin anlamlı olarak azaldığını gösterdi. 5 ve 10 mg/kg API gruplarında, R I/R hasarı önemli ölçüde hafifledi ve bu belirteçler sham grubu değerlerine yaklaştı. Sonuç: Sonuç olarak, çalışmanın sonuçları iki farklı API dozunun R I/R ile indüklenen böbrek hasarına karşı etkili olduğunu göstermiştir.

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Cite This Article

Topdağı, Ö., Güler, M. C., Eraslan, E., Akdemir, F. N. E., Tanyeli, A., Şebin, S. Ö., Şebin, E. (2024). Can Apigenin Be an Effective Therapeutic Agent Against Experimental Renal Ischemia-Reperfusion Injury?. Pediatric Practice and Research, Volume: 12 Issue: 2. https://doi.org/10.21765/pprjournal.1487201

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