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Journals / Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi / 2018 / Cilt: 32 - Sayı: 3

THE PLATELET-LYMPHOCYTE RATIO COMPARED WITH PNEUMONIA SEVERITY INDEX IN THE PREDICTION OF COMMUNITY-ACQUIRED PNEUMONIA

Toplumda gelişen pnömoninin öngörülmesinde trombosit-lenfosit oranı ve pnömoni ağırlık skorunun karşılaştırılması

Mustafa BOLATKALE
Pages
191–200
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

PLR may be considered as a predictive biomarker of CAP.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Community-acquired pneumonia (CAP) is a frequent cause of hospitalization and a leading cause of mortality worldwide.
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Key Findings & Data:Material and Method: This prospective case-control study included 78 patients admitted with CAP and 78 control patients.
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Conclusion & Impact:PLR may be considered as a predictive biomarker of CAP.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Pnömoni ağırlık skoru · trombosit-lenfosit oranı · C-reaktif protein

Abstract

Objective: Community-acquired pneumonia (CAP) is a frequent cause of hospitalization and a leading cause of mortality worldwide. The pneumonia severity index (PSI) is a clinical prediction score for determining short-term mortality and morbidity in patients with community-acquired pneumonia. The usefulness of rapid biochemical tests in predicting the severity of pneumonia have been investigated. Platelet-lymphocyte ratio (PLR) have been proposed as indicators of systemic inflammation and infection. The aim of this study was to investigate the predictive value of PLR levels and its association with PSI in patients with CAP in the emergency department. Material and Method: This prospective case-control study included 78 patients admitted with CAP and 78 control patients. The PLR mean levels were compared between the study and control group. PSI were calculated and C-reactive protein (CRP) were measured. Correlation analyses were performed to investigate the association of PLR levels with CRP, PSI and hospitalization. Results: PLR levels were significantly higher in the study group compared to the control group (p <0.001).The PLR level of 140,5 had sensitivity of 70.5% and specificity of 82.1% and was positively correlated with PSI, CRP and hospitalization (r = 0.333; p= 0.003, r = 0.478; p <0.001, r=0.386; p<0.001). PLR levels were significantly higher in the inpatients subgroup compared to the outpatients subgroup (p= 0,001). Conclusion: PLR levels significantly increased and positively correlated with PSI, CRP and hospitalization in adult patients presenting with CAP. PLR may be considered as a predictive biomarker of CAP.

Özet

Amaç: Toplumda gelişen pnömoni (TGP), hastaneye yatışın sık nedenidir ve dünya çapında önde gelen ölüm nedenidir. Pnömoni ağırlık skoru (PAS), TGP hastalarında kısa süreli mortaliteyi ve morbiditeyi belirlemek için kullanılan bir klinik tahmin skorudur. Pnömoni ağırlığını belirlemek için hızlı biyokimyasal tetkiklere yönelik çalışmalar yapılmaktadır. Trombosit-lenfosit oranı (TLO) sistemik inflamasyon ve enfeksiyonun göstergesi olarak önerilmiştir. Bu çalışmanın amacı acil serviste TGP'li hastalarda TLO düzeylerinin prediktif değerini ve PAS ile ilişkisini araştırmaktır. Gereç ve Yöntem: Bu prospektif vaka kontrol çalışmasında 78 TGP ile başvuran hasta ve 78 kontrol olgusu yer almıştır. Ortalama TLO düzeyleri çalışma ve kontrol grubu arasında karşılaştırıldı. PAS'ları hesaplandı ve C-reaktif protein düzeyleri (CRP) ölçüldü. TLO düzeylerinin CRP, PAS ve hastaneye yatış ile ilişkisini araştırmak için korelasyon analizleri yapıldı. Bulgular: Çalışma grubunda TLO düzeyleri kontrol grubuna göre anlamlı yüksekti (p <0,001). TLO düzeyi 140,5 için %70.5 duyarlılık ve %82.1 özgüllük saptandı. PAS, CRP ve hastaneye yatış ile pozitif korelasyon gösterdi (r = 0,333; p= 0,003, r = 0,478; p <0,001, r=0,386; p<0,001). TLO düzeyleri yatış verilen hasta alt grubunda ayaktan tedavi edilen alt grupla karşılaştırıldığında istatistiksel olarak yüksekti (p= 0,001). Sonuç: TGP ile başvuran erişkin hastalarda kan TLO düzeyleri anlamlı olarak artmış ve PAS, CRP ve hastaneye yatış ile pozitif korelasyon göstermiştir. TLO, TGP hastalığı için prediktif bir biyobelirteç olarak düşünülebilir.

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Cite This Article

BOLATKALE, M. (2018). THE PLATELET-LYMPHOCYTE RATIO COMPARED WITH PNEUMONIA SEVERITY INDEX IN THE PREDICTION OF COMMUNITY-ACQUIRED PNEUMONIA. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, Cilt: 32 - Sayı: 3, 191–200. https://ajindex.com/articles/153440

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