Journals / Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi / 2019 / Cilt: 32 - Sayı: 2

Heightened misuse risk and addictive potential of gabapentinoids: the fate of effective anxiolytics

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81–86
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EVREN, C., KARABULUT, V. (2019). Heightened misuse risk and addictive potential of gabapentinoids: the fate of effective anxiolytics. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi, Cilt: 32 - Sayı: 2, 81–86. https://ajindex.com/articles/152801

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References (10)

  1. Rogawski MA, Bazil CW. New molecular targets for antiepileptic drugs: α2δ, SV2A, and Kv7/KCNQ/M potassium channels. Curr Neurol Neurosci Rep 2008; 8:345-352.
  2. Calandre EP, Rico-Villademoros F, Slim M. Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use. Expert Rev Neurother 2016; 1263-1277.
  3. Gahr M, Freudenmann RW, Hiemke C, Kolle MA, SchonfeldtLecuona C. Pregabalin abuse and dependence in Germany: Results from a database query. Eur J Clin Pharmacol 2013; 69:1335-1342. Schifano F. Misuse and abuse of pregabalin and gabapentin: Cause for concern? CNS Drugs 2014; 28:491-496.
  4. Smith R V., Havens JR, Walsh SL. Gabapentin misuse, abuse, and diversion: A systematic review. Addiction 2016; 111:1160-1174.
  5. Montastruc F, Loo SY, Renoux C. Trends in first gabapentin and pregabalin prescriptions in primary care in the United Kingdom, 1993-2017. JAMA 2018; 320:2149-2151. Titck - Turkish Pharmaceutical and Medical Device Board. Narcotics and psychotropic substances. https://www.titck.gov. tr/faaliyetalanlari/ilac/uyusturucu-ve-psikotrop-maddeler. Accessed May 25, 2019. (Turkish) Sills GJ. The mechanisms of action of gabapentin and pregabalin. Curr Opin Pharmacol 2006; 6:108-113.
  6. Belliotti TR, Capiris T, Ekhato IV, Kinsora JJ, Field MJ, Heffner TG, Meltzer LT, Schwarz JB, Taylor CP, Thorpe AJ, Vartanian MG, Wise LD, Zhi-Su T, Weber ML, Wustrow DJ. Structureactivity relationships of pregabalin and analogues that target the α2-δ protein. J Med Chem 2005; 48:2294-2307.
  7. Bockbrader HN, Wesche D, Miller R, Chapel S, Janiczek N, Burger P. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet 2010; 49:661- 669. Dooley DJ, Taylor CP, Donevan S, Feltner D. Ca2+ channel α2δ ligands: novel modulators of neurotransmission. Trends Pharmacol Sci 2007; 28:75-82.
  8. Bonnet U, Richter EL, Isbruch K, Scherbaum N. On the addictive power of gabapentinoids: A mini-review. Psychiatr Danub 2018; 30:142-149.
  9. Martinotti G, Lupi M, Sarchione F, Santacroce R, Salone A, Berardis D, Serroni N, Cavuto M, Signorelli M, Aguglia E, Valchera A, Iasevoli F, Di Giannantonio M. The Potential of Pregabalin in Neurology, Psychiatry and Addiction: A Qualitative Overview. Curr Pharm Des 2013; 19:6367-6374.
  10. Taylor CP, Angelotti T, Fauman E. Pharmacology and mechanism of action of pregabalin: The calcium channel α2-δ (alpha2-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res 20