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Journals / Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi / 2019 / Cilt: 32 - Sayı: 1

Late-onset clozapine-induced neutropenia treated with lithium

Pelin TAŞ DÜRMÜŞ
YASEMİN GÖRGÜLÜ
MEHMET BÜLENT SÖNMEZ
Rugül KÖSE ÇINAR
Pages
74–77
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Here, we present a case of clozapine-induced neutropenia in a schizophrenic patient seen after 7 years of clozapine use and its treatment with lithium supplementation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Clozapine is a second-generation antipsychotic drug, proven to be effective in treatment-resistant schizophrenia.
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Key Findings & Data:Among patients using clozapine; the incidence of neutropenia is approximately 3% and the incidence of agranulocytosis is approximately 1%.
💡
Conclusion & Impact:Here, we present a case of clozapine-induced neutropenia in a schizophrenic patient seen after 7 years of clozapine use and its treatment with lithium supplementation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Clozapine is a second-generation antipsychotic drug, proven to be effective in treatment-resistant schizophrenia. Among patients using clozapine; the incidence of neutropenia is approximately 3% and the incidence of agranulocytosis is approximately 1%. This side effect is diminishing after 18 weeks of drug initiation. Here, we present a case of clozapine-induced neutropenia in a schizophrenic patient seen after 7 years of clozapine use and its treatment with lithium supplementation.

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Cite This Article

DÜRMÜŞ, P. T., GÖRGÜLÜ, Y., SÖNMEZ, M. B., ÇINAR, R. K. (2019). Late-onset clozapine-induced neutropenia treated with lithium. Düşünen Adam - Psikiyatri ve Nörolojik Bilimler Dergisi, Cilt: 32 - Sayı: 1, 74–77. https://ajindex.com/articles/152799

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References (12)

  1. Rajagopal S. Clozapine, agranulocytosis and benign ethnic neutropenia. Postgrad Med J 2005; 81:545-546.
  2. Myles N, Myles H, Xia S, Large M, Kisely S, Galletly C, Bird R, Siskind D. Meta-analysis examining the epidemiology of clozapine-associated neutropenia. Acta Psychiatr Scand 2018; 138:101-109.
  3. Simon L, Cazard F. Clozapine rechallenge after neutropenia in resistant schizophrenia: a review. Encephale 2016; 42:346-353. (French) Meyer N, Gee S, Whiskey E, Taylor D, Mijovic A, Gaughran F, Shergill S, MacCabe JH. Optimizing outcomes in clozapine rechallenge following neutropenia: a cohort analysis. J Clin Psychiatry 2015; 76:e1410-e1416. Alvir JM, Lieberman JA, Safferman AZ, Schwimmer JL, Schaaf JA. Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N Engl J Med 1993; 329:162-167.
  4. Dunk LR, Annan LJ, Andrews CD. Rechallenge with clozapine following leucopenia or neutropenia during previous therapy. Br J Psychiatry 2006; 188:255-263.
  5. Ghaznavi S, Nakic M, Rao P, Hu J, Brewer JA, Hannestad J, Bhagwagar Z. Rechallenging with clozapine following neutropenia: treatment options for refractory schizophrenia. Am J Psychiatry 2008; 165:813-818.
  6. Cohen D, Monden M. White blood cell monitoring during longterm clozapine treatment. Am J Psychiatry 2013; 170:366-369.
  7. Patel NC, Dorson PG, Bettinger TL. Sudden late onset of clozapine-induced agranulocytosis. Ann Pharmacother 2002; 36:1012-1015.
  8. Raja M, Azzoni A, Maisto G. Late onset neutropenia associated with clozapine. J Clin Psychopharmacol 2011; 31:780-781.
  9. Brunoni AR, Kobuti Ferreira LR, Gallucci-Neto J, Elkis H, Velloso ED, Vinicius Zanetti M. Lithium as a treatment of clozapineinduced neutropenia: a case report. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32:2006-2007.
  10. Sporn A, Gogtay N, Ortiz-Aguayo R, Alfaro C, Tossell J, Lenane M, Gochman P, Rapoport JL. Clozapine-induced neutropenia in children: management with lithium carbonate. J Child Adolesc Psychopharmacol 2003; 13:401-404.
  11. Suraweera C, Hanwella R, de Silva V. Use of lithium in clozapineinduced neutropenia: a case report. BMC Res Notes 2014; 7:635. Hazewinkel AW, Bogers JP, Giltay EJ. Add-on filgrastim during clozapine rechallenge unsuccessful in preventing agranulocytosis. Gen Hosp Psychiatry 2013; 35:576e11-576e12. Khan AA, Harvey J, Sengupta S. Continuing clozapine with granulocyte colony-stimulating factor in patients with neutropenia. Ther Adv Psychopharmacol 2013; 3:266-271.
  12. Lally J, Malik S, Whiskey E, Taylor DM, Gaughr