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Journals / Medical Records / 2026 / Cilt: 2 Sayı: 2

Effect of Gender on Morphohistopathological changes of Basilar Arteries Following Bilateral Common Carotid artery Ligation: An Experimental Study

Bilateral Arteria Carotis Communis Ligasyonu Sonrası Arteria Basilaris’te Gözüken Morfohistopatolojik Değişikliklere Cinsiyetin Etkisi: Deneysel Çalışma

Cengiz Öztürk(FACULTY OF MEDICINE)0000-0002-2000-4952
Kemal Alp Nalcı(FACULTY OF MEDICINE)0000-0003-3786-5246
Onur Ceylan(FACULTY OF MEDICINE)0000-0001-7025-0521
İsmail Malkoç(Düzce Üniversitesi Tıp Fakültesi)0000-0002-9221-510X
Mehmet Aydin(FACULTY OF MEDICINE)0000-0002-0383-9739
Pages
28–33
Publication Date
2020-07-28
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Keywords: Bilateral common carotid artery ligation (BCCAL), basilar artery (BA), stereological method

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Steno-occlusive carotid artery disease causes increased pressure, retrograde blood flow, luminal enlargement, vascular wall thinning, elongation, convolutions, vascular re-modelization, and aneurysm formation in basilar arteries.
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Key Findings & Data:Material and Methods: This study was conducted on 7 male and 7 female rabbits.
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Conclusion & Impact:Keywords: Bilateral common carotid artery ligation (BCCAL), basilar artery (BA), stereological method
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Bilateral arteria carotis communis ligasyonu · baziler arterler · stereolojik yöntem

Abstract

Aim: Steno-occlusive carotid artery disease causes increased pressure, retrograde blood flow, luminal enlargement, vascular wall thinning, elongation, convolutions, vascular re-modelization, and aneurysm formation in basilar arteries. We investigated if gender affects the severity of histomorphologic alterations of basilar arteries after bilateral common carotid artery ligation. Material and Methods: This study was conducted on 7 male and 7 female rabbits. Two of both male and female rabbits were used as a control group and the remaining were used as the study group. Permanent ligation of the common carotid arteries from just proximal of bifurcation was performed to replicate steno-occlusive carotid artery disease. Basilar artery volumes were measured by stereological methods after the sacrifice of the animals at the end of the 3rd week. Results were compared Mann-Witney U test between groups. Results: Luminal enlargement, wall thinning, elongation, convolutions, and doligoectatic configurations were detected in the majority of basilar arteries. The mean basilar arterial volume values were estimated as male rabbits were 3.65 ± 0.35 mm3 in control and 4.96 ± 0.99 mm3 in the study group. The mean basilar arterial volume values were estimated as female rabbits were 3.97 ± 0.40 mm3 in control and 6.32 ± 1.13 mm3 in the study group. The severity of basilar enlargement was significantly higher in the female rabbits compared with the male rabbits (p < 0.01). Conclusion: Bilateral common carotid artery ligation causes more severe luminal enlargement, wall thinning, elongation, convolution, and aneurysm formation in female rabbits than males. Keywords: Bilateral common carotid artery ligation (BCCAL), basilar artery (BA), stereological method

Özet

incelmesi, uzama, kıvrılma, vasküler remodelizasyon ve anevrizmalara sebep olabilir. Biz cinsiyetin bilateral arteria carotis communis ligasyonu sonucu oluşan histomorfolojik değişikliklerin derecesine olan etkisini araştırdık. Materyal ve Metot: Bu çalışma 7 dişi ve 7 erkek tavşan üzerinde yapılmıştır. Hem erkek hem de dişi tavşanlardan ikisi kontrol, diğerleriyse deney grubu olarak kullanıldı. Arteria carotis communis bifurkasyonunun hemen proksimalinden uygulanan kalıcı ligasyon, steno-oklüziv karotis arter hastalığını tekrarlamak için yapıldı. Hayvanlar üzerinde yapılan bu çalışmanın 3. haftasında baziler arter hacmi stereolojik yöntemlerle ölçüldü. Sonuçlar Mann-Whitney U testi ile karşılaştırıldı. Bulgular: Baziler arterlerde büyük oranda luminal genişleme, duvar incelmesi, uzaması, kıvrılması ve doligoektatik kümelenme tespit edildi. Baziler arterlerin ortalama hacmi erkek kontrol grubu tavşanlarında 3,65 ± 0,35 mm3, erkek deney tavşanlarında ise 4.96 ± 0.99 mm3 olarak değerlendirildi. Baziler arterlerin ortalama hacim değerleri dişi kontrol grubu tavşanlarında 3,97 ± 0,40 mm3, dişi deney tavşanlarında ise 6,32 ± 1,13 mm3 olduğu tespit edildi. Baziler arter genişlemesi dişi tavşanlarda erkeklerden gözle görülür derecede belirgindi (p<0.01). Sonuç: Bilateral arteria carotis communis ligasyonu, dişi tavşanlarda erkek tavşanlara göre daha belirgin luminal genişleme, duvar incelmesi, uzama, kıvrılma ve anevrizmalara sebep oluyor.

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Cite This Article

Öztürk, C., Nalcı, K. A., Ceylan, O., Malkoç, İ., Aydin, M. (2020). Effect of Gender on Morphohistopathological changes of Basilar Arteries Following Bilateral Common Carotid artery Ligation: An Experimental Study. Medical Records, Cilt: 2 Sayı: 2, 28–33. https://doi.org/10.37990/medr.760505

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