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Journals / Medical Records / 2026 / Cilt: 5 Sayı: 3

Ultrastructural Changes and Inflammatory Processes of Day-Dependent Cisplatin Administration on Rat Cardiac Tissue

Tuba Ozcan Metin(Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Histology and Embryology)0000-0003-0624-026X
Gulsen Bayrak(Usak University, Faculty of Medicine, Department of Histology and Embryology)0000-0002-1397-7203
Selma Yaman(Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Biophysics)0000-0002-9301-9119
Adem Doğaner(Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Biostatistics and Medical Informatics,)0000-0002-0270-9350
Atila Yoldaş(Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Anatomy)0000-0002-7807-0661
Nadire Eser(Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Pharmacology)0000-0003-1607-5114
Duygun Altıntaş Aykan(Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Pharmacology)0000-0001-8224-4006
Banu Yılmaz(Mersin University, Faculty of Medicine, Department of Histology and Embryology)0000-0002-7723-9146
Akif Hakan Kurt(Bolu Abant Izzet Baysal University, Faculty of Medicine, Department of Pharmacology)0000-0003-2940-3172
Mehmet Şahin(Gaziantep University, Faculty of Medicine, Department of Medical Biology)0000-0001-8312-5156
Gulsah Gurbuz(Mersin University, Faculty of Medicine, Department of Histology and Embryology)0000-0001-9623-2751
Pages
573–7
Publication Date
2023-09-18
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, these findings suggest that the potential therapeutic approaches to reduce mitochondrial damage and inflammation against toxicity caused by CP may provide for clinically significant prevention when using the drug for an extended period of time.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Cisplatin (CP) is used to treat a variety of cancers as a chemotherapeutic agent.
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Key Findings & Data:Material and Methods: Rats were randomly divided into three experimental groups; control (only saline), CP D2 (treated with CP 2.5 mg/kg/day for 2 days), and CP D7 (treated with CP 2.5 mg/kg/day for 7 days).
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Conclusion & Impact:Therefore, these findings suggest that the potential therapeutic approaches to reduce mitochondrial damage and inflammation against toxicity caused by CP may provide for clinically significant prevention when using the drug for an extended period of time.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Cardiotoxicity · cisplatin · inflammation

Abstract

Aim: Cisplatin (CP) is used to treat a variety of cancers as a chemotherapeutic agent. This drug has also severe side effects and its use exhibits serious toxicity in a number of organs, including kidney and heart. The aim of the present study was to evaluate the ultrastructural and inflammatory changes induced by CP treatment in rat cardiac tissue in a time-dependent manner. Material and Methods: Rats were randomly divided into three experimental groups; control (only saline), CP D2 (treated with CP 2.5 mg/kg/day for 2 days), and CP D7 (treated with CP 2.5 mg/kg/day for 7 days). Cardiac tissues were examined under an electron microscope. Inflammation markers including tumor necrosis factor-α (TNF-α) and interleukin 1β (IL-1β) were analyzed by immunohistochemistry. In addition, electrocardiography was performed to measure the electrical activity. Results: The ultrastructural analysis of the CP D7 group revealed that myofibrils were disrupted and disorganized, mitochondria degenerated, and interstitial edema developed. When compared to the control and CP D2 groups, there was a noticeable increase in the level of TNF-α and IL-1β expression in the CP D7 group according to immunohistochemistry results. Electrocardiography showed that RR interval was longer in CP D7 than CP D2 and control groups. Conclusion: CP for 7 days damaged the ultrastructural morphology in cardiac tissue. Therefore, these findings suggest that the potential therapeutic approaches to reduce mitochondrial damage and inflammation against toxicity caused by CP may provide for clinically significant prevention when using the drug for an extended period of time.

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Cite This Article

Metin, T. O., Bayrak, G., Yaman, S., Doğaner, A., Yoldaş, A., Eser, N., Aykan, D. A., Yılmaz, B., Kurt, A. H., Şahin, M., Gurbuz, G. (2023). Ultrastructural Changes and Inflammatory Processes of Day-Dependent Cisplatin Administration on Rat Cardiac Tissue. Medical Records, Cilt: 5 Sayı: 3, 573–7. https://doi.org/10.37990/medr.1307336

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