Journals / Akademik Gastroenteroloji Dergisi / 2014 / Cilt: 13 - Sayı: 3

The development of Crohn's disease, a paradoxical side effect in a patient who used adalimumab for the treatment of ankylosing spondylitis

Ankilozan spondilit nedeniyle adalimumab kullanan bir hastada paradoksal olarak gelişen Crohn hastalığı

Pages
118–121
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this report we describe the case of a patient with ankylosing spondylitis who developed Crohn's disease, a paradoxical side effect in the use of adalimumab.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Anti-tumor necrosis factor agents are highly effective drugs for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
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Key Findings & Data:Paradoxical side effects related with these agents have been reported in recent years, primarily as case reports.
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Conclusion & Impact:In this report we describe the case of a patient with ankylosing spondylitis who developed Crohn's disease, a paradoxical side effect in the use of adalimumab.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Paradoksal Crohn hastalığı · Paradoxical Crohn's disease

Abstract

Anti-tumor necrosis factor agents are highly effective drugs for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Paradoxical side effects related with these agents have been reported in recent years, primarily as case reports. Ankylosing spondylitis is one of the rheumatoid diseases treated with adalimumab, a tumor necrosis factor inhibiting anti-inflammatory drug. In this report we describe the case of a patient with ankylosing spondylitis who developed Crohn's disease, a paradoxical side effect in the use of adalimumab.

Özet

Anti-tümör nekrozis faktör ajanlar, romatizmal hastalıklar ve inflamatuvar barsak hastalığı gibi farklı inflamatuvar durumlarda yüksek oranda etkili ilaçlardır. Bu ajanlara bağlı olarak gelişen paradoksal yan etkilerle ilgili son yıllarda, çoğu vaka bildirimi şeklinde olan yayınlar mevcuttur. Anti-tümör nekrozis faktör ajanların en sık kullanıldığı romatizmal hastalıklardan birisi de ankilozan spondilittir. Biz bu yazıda adalimumab kullanan ankilozan spondilitli bir hastada paradoksal olarak gelişen Crohn hastalığını sunmayı amaçladık

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Cite This Article

İPEK, S., ÇEKİÇ, C., ALPER, E., AKPINAR, Z., ÇAMYAR, H., KARTAL, M., ÜNSAL, B. (2014). The development of Crohn's disease, a paradoxical side effect in a patient who used adalimumab for the treatment of ankylosing spondylitis. Akademik Gastroenteroloji Dergisi, Cilt: 13 - Sayı: 3, 118–121. https://ajindex.com/articles/152665

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References (5)

  1. Braun J, Baraliakos X, Listing J, et al. Differences in the incidence of flares or new onset of inflammatory bowel diseases in patients with ankylosing spondylitis exposed to therapy with anti-tumor necrosis factor alpha agents. Arthritis Rheum 2007;57:639-47.
  2. Braun J, Sieper J. Biological therapies in the spondyloarthritides-the current state. Rheumatology 2004;43:1072-84.
  3. Fouache D, Goeb V, Massy-Guillemant N, et al. Paradoxical ad- verse events of anti-tumour necrosis factor therapy for spondy- loarthropathies: a retrospective study. Rheumatology (Oxford) 2009;48:761-4.
  4. Sandborn WJ, Hanauer SB, Katz S, et al. Etanercept for active Cro- hn’s disease: a randomized, double-blind, placebo-controlled trial. Gastroenterology 2001;121:1088-94.
  5. Toussirot E, Houvenagel E, Goeb V, et al. Development of inf- lammatory bowel disease during anti-TNF-a therapy for inflam- matory rheumatic disease: a nationwide series. Joint Bone Spine 2012;79:457-63.