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Journals / Medical Records / 2026 / Cilt: 6 Sayı: 2

DTI Measurements for Huntington Disease Using Mricloud

Ayla Arslan(AĞRI İBRAHİM ÇEÇEN ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-5859-7784
Mehtap Nisari(ERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-1126-7478
Emel Güler(CUMHURİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-5049-8770
Gökçe Bağcı Uzun(MALATYA TURGUT ÖZAL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-4992-6915
Murat Gültekin(ERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-0609-4269
Halil Dönmez(ERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-7145-4769
Keziban Bağcı(NİĞDE ÜNİVERSİTESİ, NİĞDE ZÜBEYDE HANIM SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU, TIBBİ HİZMETLER VE TEKNİKLER BÖLÜMÜ)0000-0002-4598-3034
Niyazi Acer(İSTANBUL AREL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-4155-7759
Pages
302–311
Publication Date
2024-05-16
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The increase of axial diffusivity and mean diffusivity values axonal degeneration and demyelination of frontal, parietal, temporal, occipital, corpus callosum, white matter, limbic, subcortical structures; increased radial diffusivity values dysmyelination of the corpus callosum and capsula interna; fractional anisotropy increased values in nucleus caudatus and putamen may indicate a degenerative process, axon loss and inflammation.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Neurodegenerative diseases are important health problems that affect many people.
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Key Findings & Data:Material and Method: 8 controls and 8 Huntington's patients participated in the study.
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Conclusion & Impact:Conclusion: The increase of axial diffusivity and mean diffusivity values axonal degeneration and demyelination of frontal, parietal, temporal, occipital, corpus callosum, white matter, limbic, subcortical structures; increased radial diffusivity values dysmyelination of the corpus callosum and capsula interna; fractional anisotropy increased values in nucleus caudatus and putamen may indicate a degenerative process, axon loss and inflammation.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Huntington disease · neurodegenerative disease · brain

Abstract

Aim: Neurodegenerative diseases are important health problems that affect many people. In this study, it was aimed to examine the brain regions of Huntington's patients by performing brain parcellation. Material and Method: 8 controls and 8 Huntington's patients participated in the study. We measured four Diffusion Tensor Imaging metrics which were axial diffusivity, mean diffusivity, radial diffusivity and fractional anisotropy performing brain parcellation over Diffusion Tensor Imaging for control and patient groups. We used a full automated data-driven approach to study the whole brain, divided in regions of interest using mricloud. Results: When the huntington disease group compared to control group, We found that mean diffusivity and axial diffusivity increased frontal, parietal, temporal, occipital, corpus callosum, white matter, limbic and subcortical structures, and radial diffusivity increased corpus callosum, capsula interna (p<0.05). The fractional anisotropy value was higher in nucleus caudatus, putamen and a significant difference was observed (p<0.05). Conclusion: The increase of axial diffusivity and mean diffusivity values axonal degeneration and demyelination of frontal, parietal, temporal, occipital, corpus callosum, white matter, limbic, subcortical structures; increased radial diffusivity values dysmyelination of the corpus callosum and capsula interna; fractional anisotropy increased values in nucleus caudatus and putamen may indicate a degenerative process, axon loss and inflammation.

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Cite This Article

Arslan, A., Nisari, M., Güler, E., Uzun, G. B., Gültekin, M., Dönmez, H., Bağcı, K., Acer, N. (2024). DTI Measurements for Huntington Disease Using Mricloud. Medical Records, Cilt: 6 Sayı: 2, 302–311. https://doi.org/10.37990/medr.1421420

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