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Journals / Medical Records / 2026 / Cilt: 7 Sayı: 1

Can First Trimester Plasma Protein A Level Predict Gestational Diabetes Mellitus

Sema Baki Yıldırım(GIRESUN UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-5321-0739
Neslihan Bezirganoglu Altuntas(UNIVERSITY OF HEALTH SCIENCES, TRABZON KANUNİ HEALTH RESEARCH CENTER)0000-0002-6352-4085
Ali Muhtaroğlu(GIRESUN UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-5412-2175
Mehmet Albayrak(Giresun Gynecology and Pediatrics Training and Research Hospital)0000-0002-2371-6437
Pages
240–244
Publication Date
2025-01-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Future research should explore integrated predictive models incorporating PAPP-A and other biomarkers for improved early GDM screening.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Gestational diabetes mellitus (GDM), a condition with multifactorial etiology and adverse perinatal consequences, affects approximately 15% of pregnancies globally, with higher prevalence in certain populations, such as Türkiye.
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Key Findings & Data:Material and Method: This study involved 573 singleton pregnancies in women aged 18 to 45 years, conducted at a tertiary maternity hospital.
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Conclusion & Impact:Future research should explore integrated predictive models incorporating PAPP-A and other biomarkers for improved early GDM screening.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Gestational diabetes · pregnancy-associated plasma protein-A · pregnancy

Abstract

Aim: Gestational diabetes mellitus (GDM), a condition with multifactorial etiology and adverse perinatal consequences, affects approximately 15% of pregnancies globally, with higher prevalence in certain populations, such as Türkiye. The role of pregnancy-associated plasma protein-A (PAPP-A) on GDM risk remains unclear. This prospective study aimed to assess whether first-trimester maternal PAPP-A levels are predictive of GDM. Material and Method: This study involved 573 singleton pregnancies in women aged 18 to 45 years, conducted at a tertiary maternity hospital. PAPP-A and free β-hCG were assessed, and GDM screening was carried out using a 75 g oral glucose tolerance test. Comprehensive statistical analyses were applied to evaluate the findings. Results: Of the participants, 28.09% were diagnosed with GDM. GDM group exhibited significantly lower PAPP-A MoM levels compared to controls (p=0.042). ROC analysis revealed limited predictive utility, with a PAPP-A threshold of 0.99 demonstrating 52.3% sensitivity and 51.7% specificity. Logistic regression identified low PAPP-A levels, advanced maternal age, and higher body mass index (BMI) as independent GDM risk factors. Conclusion: While the findings underscore a potential association between PAPP-A levels and GDM, the predictive capacity of PAPP-A alone is modest. Future research should explore integrated predictive models incorporating PAPP-A and other biomarkers for improved early GDM screening.

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Cite This Article

Yıldırım, S. B., Altuntas, N. B., Muhtaroğlu, A., Albayrak, M. (2025). Can First Trimester Plasma Protein A Level Predict Gestational Diabetes Mellitus. Medical Records, Cilt: 7 Sayı: 1, 240–244. https://doi.org/10.37990/medr.1598384

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