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Journals / Medical Records / 2026 / Cilt: 7 Sayı: 2

Evaluation of Atherosclerosis and Arterial Stiffness with Angiogenic Growth Factors in Chronic Kidney Disease Patients

Musa İlker Durak(Ankara Etlik Şehir Hastanesi)0000-0003-2232-4316
Melahat Coban(Ankara Bilkent Şehir Hastanesi)0000-0001-5761-7675
Pages
314–321
Publication Date
2025-05-09
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

A significant correlation was observed between Ang-2 and atherosclerosis and AS, and an inverse relationship was found with VEGF.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Cardiovascular (CV) complications are the most common cause of mortality in patients with chronic kidney disease (CKD).The study aimed to determine the relationship between angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) and atherosclerosis as determined by carotid artery intima-media thickness (CAT) and arterial stiffness (AS) as determined by brachial-ankle pulse wave velocity (bPWV) in pre-dialysis CKD patients.
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Key Findings & Data:Material and Method: The study included 126 (47.2%) male and 141 (52.8%) female pre-dialysis CKD patients.
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Conclusion & Impact:A significant correlation was observed between Ang-2 and atherosclerosis and AS, and an inverse relationship was found with VEGF.
🔬Design:Klinik Araştırma
📍Scope:Comprehensive Sample
⚙️Variables:Atherosclerosis · arterial stiffness · chronic kidney disease

Abstract

Aim: Cardiovascular (CV) complications are the most common cause of mortality in patients with chronic kidney disease (CKD).The study aimed to determine the relationship between angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) and atherosclerosis as determined by carotid artery intima-media thickness (CAT) and arterial stiffness (AS) as determined by brachial-ankle pulse wave velocity (bPWV) in pre-dialysis CKD patients. Material and Method: The study included 126 (47.2%) male and 141 (52.8%) female pre-dialysis CKD patients. Presence of atherosclerosis was determined by CAT and presence of AS by bPWV. VEGF and Ang-2 serum levels were determined by enzyme-linked immunosorbent assays (ELISA). Results: CAT, bPWV, and log10 Ang-2 values were significantly higher in patients compared to the healthy control group. Estimated glomerular filtration rate (eGFR), C-reactive protein (CRP), total cholesterol, triglycerides, CAT, and bPWV were higher and spot urine protein creatinine ratio was lower in patients with high mean log10 Ang-2 compared to the patients with low mean log10 Ang-2. There was a significant correlation between log10 Ang-2 and bPWV and CAT, and an inverse relationship with log10 VEGF. Conclusion: Patients with CKD had increased development of atherosclerosis and AS, increased serum Ang-2 levels compared to healthy individuals. Ang-2 was significantly correlated with renal function and inversely correlated with proteinuria. Ang-2 was found to be correlated with inflammation and hyperlipidemia. A significant correlation was observed between Ang-2 and atherosclerosis and AS, and an inverse relationship was found with VEGF.

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Cite This Article

Durak, M. İ., Coban, M. (2025). Evaluation of Atherosclerosis and Arterial Stiffness with Angiogenic Growth Factors in Chronic Kidney Disease Patients. Medical Records, Cilt: 7 Sayı: 2, 314–321. https://doi.org/10.37990/medr.1603856

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