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Journals / Medical Records / 2025 / Cilt: 7 Sayı: 3

Quantitative Evaluation of the Parietal Lobes Abnormalities in Sudanese Patients with Schizophrenia: A Comparative Brain Segmentation Study

Meltem Açar Güdek(SAMSUN ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-4517-5889
Amani Elfaki(Department of Anatomy, College of Dentistry, Cihan Universty)0000-0002-1742-3849
Mert Nahir(TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ)0000-0002-8492-3704
Amira Muhammed Osman Haroun(Medical City King Salman Bn Abdalaziz)0000-0002-2026-5562
Sahar Shareef(Department of Anatomy, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia)0009-0008-3364-5880
Bünyamin Şahin(Ondokuz Mayıs Üniversitesi Tıp Fakültesi Anatomi A.D)0000-0001-8538-8443
Pages
709–16
Publication Date
2025-09-09
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These structural abnormalities may underlie specific cognitive deficits commonly associated with schizophrenia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Schizophrenia is a long-standing psychiatric condition marked by a gradual deterioration in cognitive functioning, personality organization, and affective responsiveness.
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Key Findings & Data:Material and Method: The study cohort comprised 54 patients and 82 healthy participants who met the inclusion criteria.
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Conclusion & Impact:These structural abnormalities may underlie specific cognitive deficits commonly associated with schizophrenia.
🔬Design:Klinik Araştırma
📍Scope:Comprehensive Sample
⚙️Variables:Parietal lobe · chronic schizophrenia · magnetic resonance images

Abstract

Aim: Schizophrenia is a long-standing psychiatric condition marked by a gradual deterioration in cognitive functioning, personality organization, and affective responsiveness. This study represents the first magnetic resonance imaging (MRI) investigation to explore morphological similarities and differences of the parietal lobes in Sudanese individuals diagnosed with schizophrenia. Material and Method: The study cohort comprised 54 patients and 82 healthy participants who met the inclusion criteria. All participants underwent a structured socio demographic assessment and comprehensive physical examination. Brain MRI scans were acquired and subsequently analyzed using automated brain segmentation software applied to DICOM format images. Results: The mean volume of the parietal lobe was significantly lower in patients (114.97±10.86 cm³) compared to controls (127.85±10.65 cm³). Similarly, volume reductions were seen in both gray and white matter compartments in patients (72.49±7.54 cm³ and 42.47±4.51 cm³) compared to controls (79.40±6.77 cm³ and 48.46±5.94 cm³). However, no significant difference was observed in the cortical pial surface area of the parietal lobe between groups. Parietal cortical thickness was notably diminished in patients (p≤0.05). Conclusion: The reductions observed in total parietal lobe volume, along with diminished gray and white matter volumes in individuals with schizophrenia, indicate a widespread atrophic process affecting this cerebral region. These structural abnormalities may underlie specific cognitive deficits commonly associated with schizophrenia.

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Cite This Article

Güdek, M. A., Elfaki, A., Nahir, M., Haroun, A. M. O., Shareef, S., Şahin, B. (2025). Quantitative Evaluation of the Parietal Lobes Abnormalities in Sudanese Patients with Schizophrenia: A Comparative Brain Segmentation Study. Medical Records, Cilt: 7 Sayı: 3, 709–16. https://doi.org/10.37990/medr.1700713

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