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Journals / Ege Klinikleri Tıp Dergisi / 2019 / Cilt: 57 - Sayı: 1

Investigation of Interleukin-6 Gene Promoter Region Polymorphism and Cerebral Palsy

İnterlökin-6 Geni Promotör Bölge Polimorfizmi ve Serebral Palsi İlişkisinin İncelenmesi

EVREN GÜMÜŞ
Oğuz ÇİLİNGİR
Çoşkun YARAR
Kürşat Bora CARMAN
Ozan KOCAK
Sibel LAÇİNEL GÜRLEVİK
SEVİLHAN ARTAN
Beyhan DURAK ARAS
Pages
18–22
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The evaluation of the results of studies carried out in different geographical and ethnic groups will undoubtedly make this relationship clearer.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Cerebral palsy (CP) is the most frequent cause of mobility restriction and posture disturbance in childhood.
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Key Findings & Data:Against the complexity in disease etiology, genetic factors, including Interleukin-6 promoter region polymorphism, in patient population, are worthy targets for investigation.
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Conclusion & Impact:The evaluation of the results of studies carried out in different geographical and ethnic groups will undoubtedly make this relationship clearer.
🔬Design:Research Article
📍Scope:2014 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Cerebral palsy (CP) is the most frequent cause of mobility restriction and posture disturbance in childhood. Against the complexity in disease etiology, genetic factors, including Interleukin-6 promoter region polymorphism, in patient population, are worthy targets for investigation. Method: Between December 2014 and December 2015, 78 cases and 60 control individuals evaluated in the child neurology clinic and medical genetics laboratory, were included in the study. Using the PCR-RFLP method, the relevant polymorphism was assessed with the appropriate truncation enzyme. Results: Interleukin-6-174 C / G polymorphism was not statistically different between the three groups of CC, CG, GG genotype. Interleukin-6-174 C / G polymorphism was not statistically different between the two groups including to C and G alleles. Conclusion: Our study is the first study to investigate the relationship between IL-6 promoter region polymorphism and cerebral palsy in our country. The evaluation of the results of studies carried out in different geographical and ethnic groups will undoubtedly make this relationship clearer.

Özet

Amaç: Serebral palsi (CP) çocukluk çağında hareket kısıtlılığı ve duruş bozukluğunun en sık nedenidir. Hastalık etiyolojisindeki karmaşıklığa karşı, hasta popülâsyonundaki İnterlökin-6 promotör bölge polimorfizmi de dâhil olmak üzere genetik faktörler araştırmaya değer hedeflerdir. Yöntem: Aralık 2014-Aralık 2015 arasında çocuk nöroloji kliniğinde ve tıbbi genetik laboratuvarında değerlendirilen 78 olgu ve 60 kontrol birey çalışmaya dâhil edildi. PZR-RFLP yöntemini kullanarak, ilgili polimorfizm uygun kesim enzimi ile değerlendirildi. Bulgular: İnterlökin-6 -174 C/G polimorfizmi için yapılan değerlendirmede, CC, CG, GG genotipine sahip olma yönünden iki grup arasında istatiksel olarak bir fark saptanmamıştır. İnterlökin-6 -174 C/G polimorfizmi için yapılan değerlendirmede, C ve G allelini taşıma yönünden iki grup arasında istatiksel olarak bir fark saptanmamıştır. Sonuç: Çalışmamız ülkemizde IL-6 promotör bölge polimorfizmi ile serebral palsi ilişkisini inceleyen ilk çalışmadır. Farklı coğrafi ve etnik gruplarda yapılan çalışmaların sonuçlarının beraber değerlendirilmesi şüphesiz ki bu ilişkinin daha net ortaya konulmasını sağlayacaktır.

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Cite This Article

GÜMÜŞ, E., ÇİLİNGİR, O., YARAR, Ç., CARMAN, K. B., KOCAK, O., GÜRLEVİK, S. L., ARTAN, S., ARAS, B. D. (2019). Investigation of Interleukin-6 Gene Promoter Region Polymorphism and Cerebral Palsy. Ege Klinikleri Tıp Dergisi, Cilt: 57 - Sayı: 1, 18–22. https://ajindex.com/articles/152091

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