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Journals / Journal of the Turkish Chemical Society Section A: Chemistry / 2016 / Volume: 3 Issue: 3 Special Issue

DETERMINATION OF COCAINE AND BENZOYLECGONINE IN BIOLOGICAL MATRICES BY HPLC AND LC-MS/MS.

Zinar Pinar Gumus
Veysel Umut Celenk
Emine Guler
Bilal Demir
Hakan Coskunol
Suna Timur
Pages
—
Publication Date
2017-01-08
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Also the matrices and concentrations were determined by HPLC instrument could be used where necessary.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Cocaine is a powerfully addictive illicit drug.
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Key Findings & Data:Cocaine abuse and addiction continue to increase in the world.
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Conclusion & Impact:Also the matrices and concentrations were determined by HPLC instrument could be used where necessary.
🔬Design:Article
📍Scope:Comprehensive Sample
⚙️Variables:cocaine · benzoylecgonine · HPLC

Abstract

Cocaine is a powerfully addictive illicit drug. Cocaine abuse and addiction continue to increase in the world. Most analytical tests for the detection of cocaine use include the analysis of the metabolite, benzoylecgonine, in the urine. Benzoylecgonine is a major urinary metabolite of cocaine. Generally, the most common biologic matrices used for the analysis of cocaine contain the urine and blood however saliva was also added as a matrix in this study. Practical, quick, reliable, precise and accurate, reproducible analytical methods have been developed and validated for cocaine and benzoylecgonine. In addition, this chromatographic techniques were used as both initial test and confirmatory. The validated chromatographic method was successfully applied to the analysis of cocaine and benzoylecgonine compounds in synthetic biological matrix. Confirmation analyses were made by LC-MS/MS to support reliability of HPLC results. As a result of this study, it can be claimed that HPLC could be a good alternative for the analyses of various biological matrices in forensic studies. Also the matrices and concentrations were determined by HPLC instrument could be used where necessary.

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Cite This Article

Gumus, Z. P., Celenk, V. U., Guler, E., Demir, B., Coskunol, H., Timur, S. (2017). DETERMINATION OF COCAINE AND BENZOYLECGONINE IN BIOLOGICAL MATRICES BY HPLC AND LC-MS/MS.. Journal of the Turkish Chemical Society Section A: Chemistry, Volume: 3 Issue: 3 Special Issue. https://doi.org/10.18596/jotcsa.82665

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