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Journals / Anadolu Psikiyatri Dergisi / 2019 / Cilt: 20 - Sayı: 6

The relation of trauma type on the levels of plasma C-reactive protein in patients with post-traumatic stress disorder

Travma sonrası stres bozukluğu hastalarında travma tipinin plazma C-reaktif protein düzeyi ile ilişkisi

Naci OLAM
Alisan Burak YASAR
Pages
573–580
DOI
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Conclusion: As a result, there were differences in plasma CRP levels between PTSD patients and healthy control group and plasma CRP levels were found to vary with the type of trauma associated with PTSD. (Anatolian Journal of Psychiatry 2019; 20(6):573-580)

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Studies investigating the relationship between posttraumatic stress disorder (PTSD) that is chronic psychiatric disorder and C-reactive protein (CRP) level have inconsistent results.
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Key Findings & Data:Methods: The sample of this cross-sectional study consisted of 73 PTSD patients and 69 healthy control subjects.
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Conclusion & Impact:Conclusion: As a result, there were differences in plasma CRP levels between PTSD patients and healthy control group and plasma CRP levels were found to vary with the type of trauma associated with PTSD. (Anatolian Journal of Psychiatry 2019; 20(6):573-580)
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Studies investigating the relationship between posttraumatic stress disorder (PTSD) that is chronic psychiatric disorder and C-reactive protein (CRP) level have inconsistent results. However, to our knowledge, there is no study investigating the effect of PTSD-related trauma type on plasma CRP levels. This study was planned to determine the effect of PTSD and PTSD-related trauma type on plasma CRP levels. Methods: The sample of this cross-sectional study consisted of 73 PTSD patients and 69 healthy control subjects. After proper blood collection, Clinician-Administered PTSD Scale (CAPS) was administered by the researchers and Sociodemographic Data Form, Beck Depression Inventory (BDI) and Dissociative Experiences Scale (DES) were requested. Results: CRP, BDI and DES scores of PTSD patients were statistically higher than healthy controls. There were statistically signifi- cant differences between plasma CRP level, CAPS and DES scores according to different trauma types. In the comparison of bilateral groups, plasma CRP levels of occupational accident-induced PTSD patients were statis- tically higher than patients with PTSD due to other types of trauma. Conclusion: As a result, there were differences in plasma CRP levels between PTSD patients and healthy control group and plasma CRP levels were found to vary with the type of trauma associated with PTSD. (Anatolian Journal of Psychiatry 2019; 20(6):573-580)

Özet

Amaç: Kronik psikiyatrik bir bozukluk olan travma sonrası stres bozukluğu (TSSB) ile C-reaktif protein (CRP) düzeyi arasındaki ilişkiyi araştıran çalışmalar tutarsız sonuçlara sahiptir. Bildiğimiz kadarıyla TSSB ilişkili travma tipinin, plazma CRP düzeyi üzerine etkisini inceleyen çalışma yoktur. Bu çalışma TSSB’nin ve TSSB ilişkili travma tipinin plazma CRP düzeyine etkisini saptamak amacıyla planlanmıştır. Yöntem: Bu kesitsel çalışmanın örneklemini, 73 TSSB hastası ve 69 sağlıklı kontrol olgusu oluşturmaktadır. Katılımcılardan usulüne uygun kan alındıktan sonra, klinisyen tarafından uygulanan TSSB Ölçeği (CAPS) katılımcılara uygulanmış ve Sosyodemografik Veri Formu, Beck Depresyon Ölçeği (BDÖ) ve Dissosiyatif Yaşantılar Ölçeği (DES) içeren bir form doldurmaları istenmiştir. Bulgular: TSSB hastalarının CRP, BDÖ ve DES puanları sağlıklı kontrollere göre istatistiksel olarak yüksek bulun- muştur. Farklı travma tiplerine göre plazma CRP düzeyi, CAPS ve DES puanları arasında istatistiksel olarak anlamlı farklılıklar bulunmuştur. İkili grup karşılaştırılmalarında, iş kazası kaynaklı TSSB hastalarının plazma CRP düzeyleri, diğer travma tiplerine bağlı TSSB hastalarından istatiksel olarak daha yüksekti. Sonuç: Sonuç olarak TSSB hasta- ları ile sağlıklı kontrol grubu arasında, plazma CRP düzeyi farklılıkları olduğunu ve plazma CRP düzeyinin TSSB ilişkili travma tipi ile değişebileceğini öneren sonuçları saptadık. (Anadolu Psikiyatri Derg 2019; 20(6):573-580)

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Cite This Article

OLAM, N., YASAR, A. B. (2019). The relation of trauma type on the levels of plasma C-reactive protein in patients with post-traumatic stress disorder. Anadolu Psikiyatri Dergisi, Cilt: 20 - Sayı: 6, 573–580. https://ajindex.com/articles/151502

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References (13)

  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-5®). Arlington: American Psychiatric Pub., 2013.
  2. Kessler RC, Berglund P, Demler O, Jin R, Meri- kangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005; 62:593-602.
  3. Dennis PA, Weinberg JB, Calhoun PS, Watkins LL, Sherwood A, Dennis MF, et al. An investi- gation of vago-regulatory and health-behavior accounts for increased inflammation in posttrau- matic stress disorder. J Psychosom Res 2016; 83:33-39.
  4. Mendoza C, Barreto GE, Avila-Rodriguez M, Echeverria V. Role of neuroinflammation and sex hormones in war-related PTSD. Mol Cell Endocrinol 2016; 434:266-277.
  5. Wang W, Wang L, Xu H, Cao C, Liu P, Luo S, et al. Characteristics of pro-and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake. J Affect Disord 2019; 248:52-58.
  6. Gündüz A, Yaşar AB, Gündoğmuş İ, Konuk E. Adverse Childhood Events Turkish Form: validity and reliability study. Anatolian Journal of Psychiatry 2018; 19:68-75.
  7. Bolu A, Aydın MS, Akgün A, Coşkun A, Çelik C, Uzun Ö, et al. Altered serum levels of high sensi- tivity C-reactive protein in first-episode drugnaive and chronic medicated schizophrenia. Bulletin of Clinical Psychopharmacology 2018; 28:13-13.
  8. Gundogmus İ, Algul A, Karagöz A, Kıyançiçek M. PDW and RDW are new parameters for bipolar episodes and unipolar depression. Psychiatry and Clinical Psychopharmacology 2018; 28:1-7.
  9. Asdemir A, Turan T, Uysal C, Kilic E. A potential biomarker for bipolar I disorder: serum arginine vasopressin levels. Anatolian Journal of Psychi- atry 2017; 18:195-203.
  10. Chamberlain SR, Cavanagh J, de Boer P, Mon- delli V, Jones DN, Drevets WC, et al. Treatment- resistant depression and peripheral C-reactive protein. Br J Psychiatry 2019; 214:11-19.
  11. Gündüz N, Timur O, Erzincan E, Tural U. The mean platelet volume, neutrophil lymphocyte ratio, platelet lymphocyte ratio and red cell distri- bution width in panic disorder. Anatolian Journal of Psychiatry 2018; 19: 5-13.
  12. Lindqvist D, Dhabhar FS, Mellon SH, Yehuda R, Grenon SM, Flory JD, et al. Increased pro-inflam- matory milieu in combat related PTSD–a new cohort replication study. Brain Behav Immun 2017; 59:260-264.
  13. Spitzer C, Barnow S, Völzke H, Wallaschofski H, John U, Freyberger HJ, et al. Association of post- traumatic stress disorder with low-grade elevation of C-reactive protein: