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Journals / Journal of the Turkish Chemical Society Section A: Chemistry / 2026 / Volume: 2026 Issue: 2

A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions

Rabia Zeynep Kobak(Istanbul Technical University, Faculty of Science and Letters)0000-0001-9140-7487
Barbaros Akkurt(İSTANBUL TEKNİK ÜNİVERSİTESİ)0000-0003-4066-3004
Pages
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Publication Date
2026-06-02
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It is hoped that the readers will find this treatise useful.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Imidazo[1,2-a]pyridine is a powerful molecule, with thousands of references in the literature.
📊
Key Findings & Data:It is used as an enzyme inhibitor (for example, c-MET kinase, tyrosine kinase, serine/threonine kinase), antimicrobial agent (for Gram positive and negative bacteria), antitubercular compounds, nematicides and fungicides, antiviral agents against HIV viruses, and some reports mention of antifungal activity, anticancer activity (for example, PC-3 and MDA-MB-231, B16F10, MCF-7, HCT116, and HepG2 are discussed in this paper) and some metal complexes as mRNA inhibitor and sensor devices and their syntheses and related applications are becoming quite important in the chemical community.
💡
Conclusion & Impact:It is hoped that the readers will find this treatise useful.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:imidazo[1 · 2-a]pyridine · synthetic procedures

Abstract

Imidazo[1,2-a]pyridine is a powerful molecule, with thousands of references in the literature. The main reason is that the very positions of nitrogen atoms within the heterocyclic ring give rise to a wide range of activities. It is used as an enzyme inhibitor (for example, c-MET kinase, tyrosine kinase, serine/threonine kinase), antimicrobial agent (for Gram positive and negative bacteria), antitubercular compounds, nematicides and fungicides, antiviral agents against HIV viruses, and some reports mention of antifungal activity, anticancer activity (for example, PC-3 and MDA-MB-231, B16F10, MCF-7, HCT116, and HepG2 are discussed in this paper) and some metal complexes as mRNA inhibitor and sensor devices and their syntheses and related applications are becoming quite important in the chemical community. In this review article, we will discuss the biological activities and chemical synthesis methods of this heterocyclic compound, including its synthesis and the synthesis of other molecules starting from it. We also discussed the effect of substituents on the biological activity of the final compounds, where applicable. It is hoped that the readers will find this treatise useful.

🔖

Cite This Article

Kobak, R. Z., Akkurt, B. (2026). A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions. Journal of the Turkish Chemical Society Section A: Chemistry, Volume: 2026 Issue: 2. https://doi.org/10.18596/jotcsa.1886458

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