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Journals / Journal of Surgery and Medicine / 2026 / Cilt: 4 Sayı: 8

Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats

Tadalafil ve telmisartanın bleomisine bağlı akciğer fibrozisi üzerindeki etkilerinin incelenmesi

İlke Onur Kazaz(KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY)0000-0002-2106-0016
Güner Kemal Özgür(KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY)0000-0002-6872-2355
Ümit Çobanoğlu(KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF MEDICAL PATHOLOGY)0000-0001-6429-427X
Nuri İhsan Kalyoncu(KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF MEDICAL PHARMACOLOGY)0000-0002-7362-6560
Ersagun Karagüzel(KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY)0000-0003-4270-0147
Murat Topbaş(KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF PUBLIC HEALTH)0000-0003-4047-4027
Hüseyin Eren(RECEP TAYYIP ERDOGAN UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY)0000-0002-1406-8781
Seher Nazlı Kazaz(KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE)0000-0002-8181-000X
Rasin Özyavuz(KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY)0000-0002-7362-6560
Pages
689–692
Publication Date
2020-08-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Tadalafil and telmisartan were found to decrease fibrosis scores, which were increased with bleomycin, concluding that pulmonary toxicity was related to multiple processes and preventable.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Pulmonary toxicity related to bleomycin, an antitumor drug used in the treatment of several malignancies, is a challenge, and studies to find out molecules to prevent it are ongoing.
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Key Findings & Data:Methods: A total of 32 male rats were divided into four groups: Control group, Bleomycin group, Bleomycin-plus-Tadalafil group and Bleomycin-plus-Telmisartan group.
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Conclusion & Impact:Conclusion: Tadalafil and telmisartan were found to decrease fibrosis scores, which were increased with bleomycin, concluding that pulmonary toxicity was related to multiple processes and preventable.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:pulmoner fibrozis · bleomisin · Telmisartan

Abstract

Aim: Pulmonary toxicity related to bleomycin, an antitumor drug used in the treatment of several malignancies, is a challenge, and studies to find out molecules to prevent it are ongoing. In this study, we aimed to investigate the effectiveness of telmisartan and tadalafil in an experimental rat model of bleomycin-induced lung fibrosis. Methods: A total of 32 male rats were divided into four groups: Control group, Bleomycin group, Bleomycin-plus-Tadalafil group and Bleomycin-plus-Telmisartan group. Lung fibrosis was achieved by intratracheal administration of bleomycin, and the same procedure was performed to the control group, but saline was substituted for bleomycin. Tadalafil and telmisartan were administered with an orogastric catheter for 14 days. Tissue malondialdehyde levels (MDA) were determined using colorimetric methods. Masson’s trichrome staining was used in the histological examination of the tissue samples. Results: The fibrosis scores of bleomycin-plus-tadalafil and bleomycin-plus-telmisartan groups were lower than that of the bleomycin group (P=0.007 and P=0.007, respectively). MDA levels did not differ among study groups. Conclusion: Tadalafil and telmisartan were found to decrease fibrosis scores, which were increased with bleomycin, concluding that pulmonary toxicity was related to multiple processes and preventable.

Özet

Amaç: Farklı malignitelerin tedavisinde kullanılan bir antitümör ilaç olan bleomisin ile ilişkili pulmoner toksisite, önemli bir sorundur ve bu toksisiteyi önleyecek molekülleri bulmak için çalışmalar devam etmektedir. Bu deneysel çalışmada, ratlarda, bleomisinle indüklenen akciğer fibrozisinde telmisartan ve tadalafilin etkinliğini araştırmayı amaçladık. Yöntemler: 32 erkek rat dört gruba ayrıldı: Kontrol grubu, Bleomisin grubu, Bleomisin+Tadalafil grubu, Bleomisin+Telmisartan grubu. Akciğer fibrozisi intratrakeal bleomisin uygulaması ile oluşturulurken aynı prosedür kontrol grubunda bleomisin yerine salin kullanılarak uygulandı. Tadalafil ve telmisartan gruplara göre 14 gün boyunca orogastrik kateter vasıtasıyla verildi. Doku MDA düzeyleri kalorimetrik yöntemler kullanılarak ölçüldü. Masson trikrom boyama uygulanarak histolojik değerlendirme yapıldı. Bulgular: Bleomisin+tadalafil ve bleomisin+telmisartan gruplarının fibrozis skorları bleomisin grubuna göre daha düşüktü. Gruplar arasında MDA düzeyleri açısından farklılık görülmedi. Sonuç: Tadalafil ve telmisartanın bleomisine bağlı artan fibrozis skorlarını düşürdüğü ve pulmoner toksisitenin birden fazla süreçle ilişkili olduğu ve önlenebilir olduğu kanısındayız.

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Cite This Article

Kazaz, İ. O., Özgür, G. K., Çobanoğlu, Ü., Kalyoncu, N. İ., Karagüzel, E., Topbaş, M., Eren, H., Kazaz, S. N., Özyavuz, R. (2020). Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats. Journal of Surgery and Medicine, Cilt: 4 Sayı: 8, 689–692. https://doi.org/10.28982/josam.780681

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