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Journals / Journal of Surgery and Medicine / 2026 / Cilt: 4 Sayı: 11

Right ventricular dysfunction in cirrhosis: A speckle-tracking echocardiography study

Sirozda sağ ventrikül disfonksiyonu: Speckle-tracking ekokardiyografi çalışması

Deniz Ogutmen Koc(University of Health Sciences Gaziosmanpasa Training and Research Hospital, Department of Gastroenterology)0000-0003-2738-625X
Tayfun Şahin(Kocaeli University School of Medicine, Department of Cardiology)0000-0002-0851-2946
Sila Oksuz(University of Health Sciences Gaziosmanpasa Training and Research Hospital, Department of Internal Medicine)0000-0003-4721-0585
Hulya Cebe(University of Health Sciences Gaziosmanpasa Training and Research Hospital, Department of Cardiology)0000-0003-1954-406X
Ali Erkan Duman(Kocaeli University School of Medicine, Department of Gastroenterology)0000-0002-7093-2503
Yasemin Gökden(University of Health Sciences Cemil Tascıoglu City Hospital, Department of Gastroenterology)0000-0001-6767-3072
Ugur Korkmaz(Adatip Istanbul Hospital, Department of Gastroenterology)0000-0002-1103-5343
Tanyeli Güneyligil(Gaziantep University Faculty of Medicine, Department of Biostatistics)0000-0002-4191-1244
Pages
1036–1040
Publication Date
2020-11-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In addition, the LVEF was low and LV-GLS was normal in patients with cirrhosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The majority of studies on cardiac dysfunction in patients with cirrhosis are associated with left ventricular (LV) myocardial dysfunction, with fewer studies on right ventricular (RV) function.
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Key Findings & Data:Methods: We included 50 hospitalized and ambulatory patients with cirrhosis and 33 healthy controls.
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Conclusion & Impact:In addition, the LVEF was low and LV-GLS was normal in patients with cirrhosis.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Sirotik kardiyomiyopati · Sağ ventrikül disfonksiyonu · Ekokardiyografi

Abstract

Aim: The majority of studies on cardiac dysfunction in patients with cirrhosis are associated with left ventricular (LV) myocardial dysfunction, with fewer studies on right ventricular (RV) function. The aims of this study were to evaluate biventricular function, particularly RV function, in patients with cirrhosis and investigate its relationship with disease severity. Methods: We included 50 hospitalized and ambulatory patients with cirrhosis and 33 healthy controls. Echocardiographic evaluation was performed with speckle-tracking analysis. Liver disease was graded according to Child-Pugh and Model for End-Stage Liver Disease (MELD) scores. Results: In our study, the most prevalent etiology of cirrhosis was viral hepatitis (60%), followed by non-alcoholic fatty liver disease (24%). RV-global longitudinal strain (GLS) and LV ejection fraction (EF) values were lower in patients with cirrhosis compared to the control group (both, P=0.001). LVEF was <55% in 19 (38%) patients. Decreases in RV-GLS and LVEF values were more common in patients with ascites (both, P=0.001). However, measurements of RV-GLS and LVEF did not distinguish the degree of severity of liver disease on the basis of Child-Pugh and MELD scores. LV-GLS values between patients with cirrhosis and the control group were similar (P=0.896). Conclusions: This study showed that RV function was impaired in patients with cirrhosis and more commonly, in patients with ascites. However, values of RV-GLS did not distinguish the degree of severity of liver disease. In addition, the LVEF was low and LV-GLS was normal in patients with cirrhosis.

Özet

Amaç: Sirozlu hastalarda kardiyak disfonksiyon üzerine yapılan çalışmaların çoğu, sol ventriküler (LV) miyokardiyal disfonksiyon ile ilişkilidir ve sağ ventrikül (RV) fonksiyonu üzerine daha az çalışma vardır. Bu çalışmanın amacı sirozlu hastalarda özellikle RV fonksiyonu olmak üzere, biventriküler fonksiyonu değerlendirmek ve hastalık şiddeti ile ilişkisini araştırmaktır. Yöntemler: Hastanede yatan ve ayakta tedavi gören 50 siroz hastası ve 33 sağlıklı kontrol çalışmamıza dahil edildi. Ekokardiyografik değerlendirme speckle-tracking analizi ile yapıldı. Karaciğer hastalığı Child-Pugh ve Son Evre Karaciğer Hastalığı Modeli (MELD) puanlarına göre derecelendirildi. Bulgular: Çalışmamızda sirozun en yaygın etiyolojisi viral hepatit (%60), ardından non-alkolik yağlı karaciğer hastalığı (%24) idi. Sirozlu hastalarda RV-global longitudinal strain (GLS) ve LV ejeksiyon fraksiyonu (EF) değerleri kontrol grubuna göre daha düşüktü (her ikisi de P=0.001). LVEF, 19 (% 38) hastada < %55 idi. Asitli hastalarda RV-GLS ve LVEF değerlerindeki düşüşler daha sıktı (her ikisi de, P=0,001). Bununla birlikte, RV-GLS ve LVEF ölçümleri, Child-Pugh ve MELD skorlarına göre karaciğer hastalığının şiddet derecesini ayırt etmedi. Sirozlu hastalar ile kontrol grubu arasındaki LV-GLS değerleri benzerdi (P=0.896). Sonuç: Bu çalışma, RV fonksiyonunun sirozlu hastalarda ve daha sık olarak asitli hastalarda bozulduğunu göstermiştir. Bununla birlikte, RV-GLS değerleri, karaciğer hastalığının şiddet derecesini ayırt etmedi. Ayrıca sirozlu hastalarda LVEF düşüktü ve LV-GLS normaldi.

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Cite This Article

Koc, D. O., Şahin, T., Oksuz, S., Cebe, H., Duman, A. E., Gökden, Y., Korkmaz, U., Güneyligil, T. (2020). Right ventricular dysfunction in cirrhosis: A speckle-tracking echocardiography study. Journal of Surgery and Medicine, Cilt: 4 Sayı: 11, 1036–1040. https://doi.org/10.28982/josam.818638

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