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Journals / Journal of Surgery and Medicine / 2026 / Cilt: 5 Sayı: 5

The association of TNFα -238 G/A gene polymorphism with alopecia areata

Nazlı Dizen Namdar(KÜTAHYA SAĞLIK BİLİMLERİ ÜNİVERSİTESİ)0000-0002-9116-5489
Raziye Akcılar(KÜTAHYA SAĞLIK BİLİMLERİ ÜNİVERSİTESİ)0000-0003-4720-1945
Pages
463–466
Publication Date
2021-05-01
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: These results suggest that the TNFα -238 G/A gene polymorphism is associated with AA and individuals with GA genotype may have an increased risk of AA.

📌 3 Key Takeaways

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Objective & Hypothesis:Background/Aim: Alopecia areata (AA), which is characterized by hair loss, is an inflammatory autoimmune disease.
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Key Findings & Data:Tumor necrosis factor-alpha (TNFα) is a potent proinflammatory cytokine that has a highly significant role in inflammatory and immune responses.
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Conclusion & Impact:Conclusion: These results suggest that the TNFα -238 G/A gene polymorphism is associated with AA and individuals with GA genotype may have an increased risk of AA.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:TNFα · Gene polymorphism · Alopecia areata

Abstract

Background/Aim: Alopecia areata (AA), which is characterized by hair loss, is an inflammatory autoimmune disease. Tumor necrosis factor-alpha (TNFα) is a potent proinflammatory cytokine that has a highly significant role in inflammatory and immune responses. The aim of this study is to evaluate whether there is a relationship between TNFα -238 G/A gene polymorphism and AA in the Turkish population. Methods: In this case-control study, the frequency of TNFα-238 G/A gene polymorphism and its relationship with some clinical parameters of AA patients were investigated. Seventy-eight AA patients and 78 healthy individuals were included in our study. TNFα -238 G/A polymorphism was evaluated by the PCR-RFLP method. Results: The distribution of TNFα -238 G/A genotypes was significantly different between patients and control subjects (P<0.001). Frequency of genotypes GG and AA in AA patients (53.8 and 6.4%, respectively) were evidently lower compared to the controls (59 and 25.6%, respectively). Individuals with AA genotype had a lower risk of AA disease [odds ratio (OR)=0.27; 95% CI=0.09-0.79; relative risk (RR)=0.65 (0.49-0.86); P=0.013]. GA genotype was significantly higher in patients with AA (39.7%) compared to the control group (15.4%) and an increased risk of patchy AA was observed [OR=2.82, 95% CI=1.28-6.21; RR=1.87 (1.11-3.15); P=0.008]. Conclusion: These results suggest that the TNFα -238 G/A gene polymorphism is associated with AA and individuals with GA genotype may have an increased risk of AA.

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Cite This Article

Namdar, N. D., Akcılar, R. (2021). The association of TNFα -238 G/A gene polymorphism with alopecia areata. Journal of Surgery and Medicine, Cilt: 5 Sayı: 5, 463–466. https://doi.org/10.28982/josam.892542

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