Journals / Journal of Surgery and Medicine / 2026 / Cilt: 6 Sayı: 4

Acute severe headache: Association of herpes zoster meningitis and sinus vein thrombosis

Emine Yurdakul Ertürk(ORDU UNIVERSITY, FACULTY OF MEDICINE)0000-0001-5366-647X
Hülya İnce(Clinic of Pediatrics Neurology, Medical Park Hospital)0000-0002-8923-0413
Davut Albayrak(Clinic of Pediatrics Hematology, Medical Park Hospital)0000-0002-7947-3817
Pages
524–526
Publication Date
2022-04-01
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results show an association of VZV meningitis and sinus vein thrombus.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The development of neurological complications related to varicella zoster virus (VZV) is rare, especially in immunocompetent children.
📊
Key Findings & Data:We report a case of a 14-year-old male patient who presented with severe headache and diagnosed with acute aseptic meningitis and sinus vein thrombosis caused by reactivated VZV infection.
💡
Conclusion & Impact:These results show an association of VZV meningitis and sinus vein thrombus.
🔬Design:Olgu Sunumu
📍Scope:Comprehensive Sample
⚙️Variables:Children · Headache · Herpes zoster meningitis

Abstract

The development of neurological complications related to varicella zoster virus (VZV) is rare, especially in immunocompetent children. We report a case of a 14-year-old male patient who presented with severe headache and diagnosed with acute aseptic meningitis and sinus vein thrombosis caused by reactivated VZV infection. Magnetic resonance (MR) venography identified limited flow, consistent with a thrombus in the right sigmoid sinus. Pressure of cerebrospinal fluid (CSF) was measured as high, with the PCR meningitis panel positive for VZV. These results show an association of VZV meningitis and sinus vein thrombus. Pediatric cases associated with aseptic meningitis and cerebral venous sinus thrombosis to varicella zoster reactivation have not yet been reported in the literature

🔖

Cite This Article

Ertürk, E. Y., İnce, H., Albayrak, D. (2022). Acute severe headache: Association of herpes zoster meningitis and sinus vein thrombosis. Journal of Surgery and Medicine, Cilt: 6 Sayı: 4, 524–526. https://doi.org/10.28982/josam.978248

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Yasuda R, Minami K, Ogawa A, Okada, H, Terakawa R, Koike Y, et al. Herpes zoster and meningitis in an immunocompetent child: a case report. Journal of medical case reports. 2019; 13(1): 182. https://doi.org/10.1186/s13256-019-2082-z
  2. Cunha BA, Warren-Favorito H, Mickail N. Unusually severe varicella zoster (VZV) virus viral (aseptic) meningitis in an unimmunized, immunocompetent host with chickenpox. Heart & lung: the journal of critical care. (2011); 40(4): 349–51. https://doi.org/10.1016/j.hrtlng.2010.07.005
  3. Kleinschmidt-DeMasters BK, Gilden DH. The expanding spectrum of herpesvirus infections of the nervous system. Brain pathology (Zurich, Switzerland). (2001; 11(4): 440–451. https://doi.org/10.1111/j.1750-3639.2001.tb00413.x
  4. Bredlich RO, Alfke K, Brickenstein H, Pillekamp H, Peter RU. Meningeale Reizung--eine Komplikation des Herpes zoster [Meningeal irritation--a complication of herpes zoster]. Deutsche medizinische Wochenschrift. 1998; 123(36): 1035-8. https://doi.org/10.1055/s-2007-1024115
  5. Petursson G, Helgason S, Gudmundsson S, Sigurdsson JA. Herpes zoster in children and adolescents. The Pediatric infectious disease journal. (1998); 17(10): 905-8. https://doi.org/10.1097/00006454-199810000-00011
  6. Gershon AA, Gershon MD, Breuer J, Levin MJ, Oaklander AL, Griffiths PD. Advances in the understanding of the pathogenesis and epidemiology of herpes zoster. Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology. 2010; 48(1): 2-7. https://doi.org/10.1016/S1386-6532(10)70002-0
  7. Gnann JW Jr. Varicella-zoster virus: atypical presentations and unusual complications. The Journal of infectious diseases. 2002; 186(1): 91-8. https://doi.org/10.1086/342963
  8. Ibrahim W, Elzouki AN, Husain A, Osman L. Varicella Zoster Aseptic Meningitis: Report of an Atypical Case and Literature Review. The American journal of case reports. 2015; 16: 594-7. https://doi.org/10.12659/AJCR.894045
  9. Johnson RW, Whitton TL. Management of herpes zoster (shingles) and postherpetic neuralgia. Expert opinion on pharmacotherapy. (2004); 5(3): 551-9. https://doi.org/10.1517/14656566.5.3.551
  10. Mehta A, Arora A, Sharma M, Malik R, Porwal YC. Hemorrhagic Stroke and Cerebral Venous Thrombosis: Rare Neurological Sequelae of Chickenpox Infection. Annals of Indian Academy of Neurology. 2018; 21(3): 228-32. https://doi.org/10.4103/aian.AIAN_421_1
  11. Sada S, Kammineni A, Kanikannan MA, Afshan J. Cerebral sinus venous thrombosis: a rare complication of primary Varicella zoster virus. Neurology India. 2012; 60(6): 645-6. https://doi.org/10.4103/0028-3886.105204
  12. Zhu R, Fang C, Wang J, He X. Acute Herpes Zoster Followed by Cerebral Venous Sinus Thrombosis. Neurology India. 2020; 68(1): 219-21. https://doi.org/10.4103/0028-3886.279658
  13. Jain R, Deveikis J, Hickenbottom S, Mukherji SK. Varicella-zoster vasculitis presenting with intracranial hemorrhage. AJNR. American journal of neuroradiology. 2003; 24(5): 971-4.
  14. Itrat A, Shoukat S, Kamal AK. Pathophysiology of cerebral venous thrombosis--an overview. JPMA. The Journal of the Pakistan Medical Association. 2006; 56(11): 506-8.
  15. Alataby H, Gautam R, Yuan M, Nfonoyim, J. Varicella-Zoster as a Cause of Aseptic Meningitis in an Immunocompetent Young Patient With Skin Rash. Cureus. 2020; 12(6): 8745. https://doi.org/10.7759/cureus.8745
  16. Cunha BA, Warren-Favorito H, Mickail N. Unusually severe varicella zoster (VZV) virus viral (aseptic) meningitis in an unimmunized, immunocompetent host with chickenpox. Heart & lung: the journal of critical care. (2011); 40(4): 349–51. https://doi.org/10.1016/j.hrtlng.2010.07.005
  17. Gershon AA, Gershon MD, Breuer J, Levin MJ, Oaklander AL, Griffiths PD. Advances in the understanding of the pathogenesis and epidemiology of herpes zoster. Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology. 2010; 48(1): 2-7. https://doi.org/10.1016/S1386-6532(10)70002-0