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Journals / Journal of Materials and Mechatronics: A / 2023 / Cilt: 4 Sayı: 2

Preparation of Diatomite-Chitosan Composites for Loading and Release of Diphenhydramine HCl

Difenhidramin HCl'nin Yüklenmesi ve Salımı için Diyatomit-Kitosan Kompozitlerinin Hazırlanması

Zeynep Özkan(AFYON KOCATEPE ÜNİVERSİTESİ)0000-0003-2793-157X
Muhammet Davut Arpa(İstanbul Medipol Üniversitesi)0000-0001-9290-2404
Melih Özçatal(AFYON KOCATEPE ÜNİVERSİTESİ)0000-0002-0831-9038
Hakan Çiftçi(AFYON KOCATEPE ÜNİVERSİTESİ)0000-0001-7910-7350
Pages
542–560
Publication Date
2023-12-26
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In vitro release profiles of the prepared formulations were compatible with Higuchi kinetics.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Diatomite ores have great potential as an adsorbent and drug carrier system due to their natural abundance, biocompatible, and high surface area.
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Key Findings & Data:As a result of the enrichment process, the surface area was found to be 21.7 m2/g for raw diatomite and 75.1 m2/g for calcined diatomite.
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Conclusion & Impact:In vitro release profiles of the prepared formulations were compatible with Higuchi kinetics.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Diyatomit · Kitosan · Difenhidramin

Abstract

Diatomite ores have great potential as an adsorbent and drug carrier system due to their natural abundance, biocompatible, and high surface area. In the first stage of this study, raw diatomite ore was enriched by grinding and calcination processes. As a result of the enrichment process, the surface area was found to be 21.7 m2/g for raw diatomite and 75.1 m2/g for calcined diatomite. Subsequently, a series of diatomite-chitosan composites with different composition ratios were produced. Then, the loading (adsorption) performances of diphenhydramine hydrochloride (DPH), an antihistaminic agent, were investigated on the prepared composites. The highest loading capacity was 91.1 mg/g, and the lowest loading capacity was 48.8 mg/g in the prepared DPH-loaded formulations. After DPH loading studies, DPH release profiles (desorption) and release kinetics from composites were investigated. As a result of in vitro release studies, it was observed that formulations containing chitosan polymer had slower release than chitosan free formulations. It was determined that the formulations had a cumulative release in the 70-90% range, and the release processes were completed between 45-90 minutes. In vitro release profiles of the prepared formulations were compatible with Higuchi kinetics.

Özet

Diyatomit cevherleri, doğada bol miktarda bulunmaları, biyouyumlulukları ve yüksek yüzey alanları nedeniyle adsorban ve ilaç taşıyıcı sistem olarak büyük potansiyele sahiptir. Bu çalışmanın ilk aşamasında ham diatomit cevheri öğütme ve kalsinasyon işlemleri ile zenginleştirilmiştir. Ham diyatomit için yüzey alanı 21.7 m2/g iken zenginleştirme sonrası kalsine diyatomit için 75.1 m2/g olarak bulunmuştur. Daha sonra, farklı bileşim oranlarına sahip bir dizi diatomit-kitosan kompoziti üretilmiştir. Antihistaminik ajan olan difenhidramin hidroklorürün (DPH) hazırlanan kompozitler üzerindeki yükleme (adsorpsiyon) performansları incelenmiştir. Hazırlanan DPH yüklü formülasyonlarda en yüksek yükleme kapasitesi 91.1 mg/g, en düşük yükleme kapasitesi 48.8 mg/g olmuştur. DPH yükleme çalışmalarından sonra DPH salım profilleri (desorpsiyon) ve kompozitlerden salım kinetikleri incelenmiştir. In vitro salım çalışmaları sonucunda kitosan polimeri içeren formülasyonların kitosan içermeyen formülasyonlara göre daha yavaş salım gösterdiği gözlemlenmiştir. Formülasyonların %70-90 aralığında kümülatif DPH salıma sahip olduğu ve salımın 45-90 dakika arasında tamamlandığı belirlenmiştir. Hazırlanan formülasyonların in vitro salım profilleri Higuchi kinetiği ile uyumlu olduğu belirlenmiştir.

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Cite This Article

Özkan, Z., Arpa, M. D., Özçatal, M., Çiftçi, H. (2023). Preparation of Diatomite-Chitosan Composites for Loading and Release of Diphenhydramine HCl. Journal of Materials and Mechatronics: A, Cilt: 4 Sayı: 2, 542–560. https://doi.org/10.55546/jmm.1326482

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