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Journals / Journal of Health Sciences and Medicine / 2026 / Volume: 3 Issue: 1

The prevalence of HHV-6 and variant type in HIV positive patients

HIV pozitif hastalarda HHV-6 prevalansı ve varyant tiplerinin belirlenmesi

Gülnur Tarhan(Adıyaman Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Adıyaman)0000-0002-1019-0798
Neziha Yılmaz(Yozgat Bozok Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı,Yozgat)0000-0001-9027-079X
Salih Cesur(Ankara Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara)
Pages
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Publication Date
2020-01-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall, the positivity rate was 36.3% (28/77).

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to determine the frequency of HHV-6 DNA in patients with HIV positive infection and HHV-6 variant type (variant A or variant B) in patients with HHV-6 DNA positive Material and Method: Twenty HIV-positive patients and 57 HIV negative healthy subjects were included in the study.
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Key Findings & Data:HHV-6 DNA was investigated by polymerase chain reaction (PCR) in the patient and control groups.
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Conclusion & Impact:Overall, the positivity rate was 36.3% (28/77).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:HIV · HHV-6 · varyant A

Abstract

Objective: The aim of this study was to determine the frequency of HHV-6 DNA in patients with HIV positive infection and HHV-6 variant type (variant A or variant B) in patients with HHV-6 DNA positive Material and Method: Twenty HIV-positive patients and 57 HIV negative healthy subjects were included in the study. HHV-6 DNA was investigated by polymerase chain reaction (PCR) in the patient and control groups. In cases with HHV-6 DNA positive, HHV-6 variant was investigated with restriction fragment length polymorphism (RFLP). Statistical analysis was performed using SPSS program, p≤0.05 was considered statistically significant. Results: HHV-6 DNA positivity was found to be 45% (9/20) in HIV positive patients and 33.3% (19/57) in HIV negative patients. Overall, the positivity rate was 36.3% (28/77). HHV-6 variant B was detected in HIV positive patients, but variant A was not. Conclusion: We believe that further clinical studies involving more cases are needed to determine the importance of HHV-6 seropositivity and variant types in HIV positive patients.

Özet

Amaç: Bu çalışmanın amacı HIV enfeksiyonu pozitif saptanan hastalarda HHV-6 DNA sıklığının, HHV-6 DNA’sı pozitif saptanan olgularda ise HHV-6 varyant türünün (varyant A veya varyant B) belirlenmesiydi. Gereç ve Yöntem: Çalışmaya 20 HIV pozitif hasta ile 57 HIV negatif sağlıklı birey dahil edildi. Hasta ve kontrol grubunda HHV-6 DNA’sı polimeraz zincir reaksiyonu (PZR) ile araştırıldı. HHV-6 DNA pozitif saptanan olgularda HHV-6 varyant türü restriksiyon parça uzunluğu polimorfizmi (restriction fragment lenght polymorphisim: RFLP) ile araştırıldı. İstatistiksel değerlendirme SPSS programında yapıldı, p≤0.05 istatistiksel olarak anlamlı kabul edildi. Bulgular: HIV pozitif hastalarda HHV-6 DNA pozitifliği %45 (9/20), HIV negatiflerde ise %33,3 (19/57) olarak belirlendi. Toplamda pozitiflik oranı %36,3 (28/77) idi. HIV pozitif hastalarda HHV-6 varyant B saptanırken, varyant A saptanmadı. Sonuç: HIV pozitif hastalarda HHV-6 seropozitifliği ve varyant tiplerinin öneminin belirlenmesi için daha fazla sayıda olgu içeren başka klinik çalışmalara gereksinim olduğu görüşündeyiz.

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Cite This Article

Tarhan, G., Yılmaz, N. (2020). The prevalence of HHV-6 and variant type in HIV positive patients. Journal of Health Sciences and Medicine, Volume: 3 Issue: 1. https://doi.org/10.32322/jhsm.605654

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