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Journals / Journal of Health Sciences and Medicine / 2023 / Volume: 6 Issue: 6

The investigation of serum nectin-4 levels in patients with early onset preeclampsia

Züat Acar(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KANUNİ SULTAN SÜLEYMAN HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY, PERINATOLOGY (MEDICINE))0000-0002-3485-1554
Mehmet Obut(UNIVERSITY OF HEALTH SCIENCES, DİYARBAKIR GAZİ YAŞARGİL HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY, PERINATOLOGY (MEDICINE))0000-0002-6925-4784
Zeynep Gedik Özköse(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KANUNİ SULTAN SÜLEYMAN HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY, PERINATOLOGY (MEDICINE))0000-0001-6662-8042
Sadun Sucu(UNIVERSITY OF HEALTH SCIENCES, ANKARA ETLİK ZÜBEYDE HANIM HEALTH RESEARCH CENTER FOR GYNECOLOGICAL DISEASES, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY, PERINATOLOGY (MEDICINE))0000-0003-3758-0136
Salim Sezer(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KANUNİ SULTAN SÜLEYMAN HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY, PERINATOLOGY (MEDICINE))0000-0003-1287-4306
Mevlüt Bucak(UNIVERSITY OF HEALTH SCIENCES, ANKARA ETLİK ZÜBEYDE HANIM HEALTH RESEARCH CENTER FOR GYNECOLOGICAL DISEASES, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY, PERINATOLOGY (MEDICINE))0000-0002-5035-8727
İsmail Dağ(EYÜP SULTAN HOSPİTAL, DEPARTMENT OF BİYOCHEMİSTRY)0000-0002-9432-7965
Sezgi Güllü Erciyestepe(ACIBADEM BAKIRKÖY HASTANESİ, KADIN HASTALIKLARI VE DOĞUM ANABİLİM DALI)0000-0001-5337-5461
İsmail Özdemir(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KANUNİ SULTAN SÜLEYMAN HEALTH RESEARCH CENTER, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY, PERINATOLOGY (MEDICINE))0000-0002-9043-1431
Pages
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Publication Date
2023-10-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Increased nectin-4 levels may contribute to the development of EOPE through possible oxidative, immunological, and inflammatory mechanisms adversely affecting trophoblastic cells.

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: We aimed to investigate the level and predictive value of soluble nectin-4 in early onset preeclampsia (EOPE).
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Key Findings & Data:Methods: Forty-three patients with EOPE and 41 healthy normotensive pregnant women participated in this prospective case-control study.
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Conclusion & Impact:Increased nectin-4 levels may contribute to the development of EOPE through possible oxidative, immunological, and inflammatory mechanisms adversely affecting trophoblastic cells.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Early preeclampsia · nectin-4 · preeclampsia

Abstract

Aims: We aimed to investigate the level and predictive value of soluble nectin-4 in early onset preeclampsia (EOPE). Methods: Forty-three patients with EOPE and 41 healthy normotensive pregnant women participated in this prospective case-control study. The groups were matched for gestational age and gravidity. Serum nectin-4 levels were compared between groups. The ROC curve was drawn to show the predictive value of nectin-4 for EOPE. Patients were followed up until the end of labor, and perinatal outcomes were recorded. Results: The demographic characteristics of the two groups were similar. Serum nectin-4 level was significantly increased in EOPE cases compared to controls (226.46±119.6 ng/ml vs. 156.54±44.8 ng/ml, p=0.001). The ROC showed that at > 160.938, the sensitivity and specificity were 67.44% and 82.93%, respectively [AUC:0.822, (CI:0.724 - 0.897), and (p< 0.001)]. Significant inverse correlations were found between nectin-4 levels and poor obstetric outcomes. Conclusion: Maternal serum nectin-4 levels were significantly higher in patients with EOPE compared with controls. Increased nectin-4 levels may contribute to the development of EOPE through possible oxidative, immunological, and inflammatory mechanisms adversely affecting trophoblastic cells.

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Cite This Article

Acar, Z., Obut, M., Özköse, Z. G., Sucu, S., Sezer, S., Bucak, M., Dağ, İ., Erciyestepe, S. G., Özdemir, İ. (2023). The investigation of serum nectin-4 levels in patients with early onset preeclampsia. Journal of Health Sciences and Medicine, Volume: 6 Issue: 6. https://doi.org/10.32322/jhsm.1350858

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