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Journals / Journal of Health Sciences and Medicine / 2026 / Volume: 7 Issue: 2

Frequency of seronegative cases in autoimmune hepatitis and their association with the systemic immune inflammation index

Nermin Mutlu Bilgiç(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL ÜMRANİYE SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, İÇ HASTALIKLARI ANABİLİM DALI, GASTROENTEROLOJİ BİLİM DALI)0000-0003-0486-1767
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Publication Date
2024-03-25
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

For patients suspected of autoimmune hepatitis but negative for autoantibodies, the SII could serve as a straightforward, accessible, and affordable predictor prior to liver biopsy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aims: It is suggested that a deficiency in B cells plays a role in pathogenesis of seronegative autoimmune hepatitis (snAIH).
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Key Findings & Data:Methods: In this retrospective study, 57 patients newly diagnosed with autoimmune hepatitis were included.
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Conclusion & Impact:For patients suspected of autoimmune hepatitis but negative for autoantibodies, the SII could serve as a straightforward, accessible, and affordable predictor prior to liver biopsy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Autoimmune hepatitis · Seronegative · inflammation index

Abstract

Aims: It is suggested that a deficiency in B cells plays a role in pathogenesis of seronegative autoimmune hepatitis (snAIH). The lack of B cells leads to notable changes in the variety of leukocyte types within the bloodstream. This study aimed to determine the frequency of snAIH in patients with autoimmune hepatitis, as well as to explore the relationship between snAIH and leukocyte-based inflammatory indices. Methods: In this retrospective study, 57 patients newly diagnosed with autoimmune hepatitis were included. According to clinical and pathological findings, patients were classified into seropositive autoimmune hepatitis (spAIH) and snAIH groups. The inflammation indices included the platelet to lymphocyte ratio (PLR), the neutrophil to lymphocyte ratio (NLR), and the systemic immune-inflammation index (SII). Results: The frequency of snAIH was 26.3%. The snAIH group exhibited higher NLR (3.0 vs. 1.5, p<0.001) and SII (726.1 vs. 300.8, p<0.001) levels, along with a lower PLR level (118.2 vs. 151.1, p=0.001) than the spAIH group. The threshold value of SII in predicting snAIH was ≥488.4 (sensitivity=80.9%, specificity=86.7%), and it exhibited better diagnostic performance than other inflammatory indices. Conclusion: In autoimmune hepatitis patients, snAIH exhibits by a notable prevalence and a different inflammatory landscape. For patients suspected of autoimmune hepatitis but negative for autoantibodies, the SII could serve as a straightforward, accessible, and affordable predictor prior to liver biopsy.

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Cite This Article

Bilgiç, N. M. (2024). Frequency of seronegative cases in autoimmune hepatitis and their association with the systemic immune inflammation index. Journal of Health Sciences and Medicine, Volume: 7 Issue: 2. https://doi.org/10.32322/jhsm.1446058

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