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Journals / Journal of Health Sciences and Medicine / 2026 / Volume: 8 Issue: 1

Changes in body composition and muscle strength in girls with idiopathic central precocious puberty during gonadotropin-releasing hormone agonist therapy

Gonadotropin salgılatıcı hormon agonisti tedavisi sırasında idiyopatik santral erken ergenlik dönemindeki kızlarda vücut kompozisyonunda ve kas gücünde meydana gelen değişiklikler

Zeynep Donbaloğlu(AKDENIZ UNIVERSITY)0000-0003-0605-3229
Berna Singin(AKDENIZ UNIVERSITY)0000-0002-2204-5336
Ebru Barsal Çetiner(AKDENIZ UNIVERSITY)0000-0002-1888-919X
Aynur Bedel(AKDENIZ UNIVERSITY)0000-0001-6074-7606
Bilge Aydın Behram(AKDENIZ UNIVERSITY)0000-0002-8850-0346
Kürşat Çetin(AKDENIZ UNIVERSITY)0000-0002-9022-4010
Hale Tuhan(AKDENIZ UNIVERSITY)0000-0002-7637-9630
Mesut Parlak(AKDENIZ UNIVERSITY)0000-0002-3550-1425
Pages
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Publication Date
2025-01-12
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Additionally, the alteration in PBF during GnRHa treatment exhibited variations based on the initial PBF status.

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: Our objective is to explore changes in body fat distribution and muscle strength among a cohort of girls with idiopathic central precocious puberty (ICPP) undergoing the gonadotropin-releasing hormone analogs (GnRHa) therapy.
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Key Findings & Data:Methods: A total of 50 patients who were newly diagnosed with ICPP and treated with GnRHa were included in the study.
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Conclusion & Impact:Additionally, the alteration in PBF during GnRHa treatment exhibited variations based on the initial PBF status.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Central precocious puberty · GnRHa therapy · body composition

Abstract

Aims: Our objective is to explore changes in body fat distribution and muscle strength among a cohort of girls with idiopathic central precocious puberty (ICPP) undergoing the gonadotropin-releasing hormone analogs (GnRHa) therapy. Methods: A total of 50 patients who were newly diagnosed with ICPP and treated with GnRHa were included in the study. Patients were investigated at baseline, 6th months and 12th months. Results: Body-mass index (BMI) standard deviation score (SDS) was similar throughout the treatment duration. The percentage of body fat (PBF) increased from 24.2±5.1% at the beginning to 26.3±5.3% at the 6th month and to 27.7±5.43% at the 12th month (p 97th p (p=0.005). Conclusion: Over the one-year duration of GnRHa treatment, no increase was observed in BMI SDS. While PBF increased, a decrease was noted in LBM percentage. Despite the decrease in LBM percentage, since LBM increased over the course of treatment, an increase in muscle strength was observed under GnRHa therapy. Additionally, the alteration in PBF during GnRHa treatment exhibited variations based on the initial PBF status.

Özet

Amaçlar: Amacımız, gonadotropin salgılatıcı hormon analogları (GnRHa) tedavisi gören idiyopatik santral erken ergenlik (ICPP) hastası kızlardan oluşan bir kohortta vücut yağ dağılımı ve kas gücündeki değişiklikleri incelemektir. Yöntemler: Çalışmaya yeni ICPP tanısı almış ve GnRHa ile tedavi edilen toplam 50 hasta dahil edildi. Hastalar başlangıçta, 6. ayda ve 12. ayda incelendi. Sonuçlar: Vücut kitle indeksi (VKİ) standart sapma skoru (SDS) tedavi süresi boyunca benzerdi. Vücut yağ yüzdesi (PBF) başlangıçta %24,2±5,1'den 6. ayda %26,3±5,3'e ve 12. ayda %27,7±5,43'e yükseldi (p 97. p olan grupta medyan %0,5 (0,5) idi (p=0,005). Sonuç: GnRHa tedavisinin bir yıllık süresi boyunca, BMI SDS'de artış gözlenmedi. PBF artarken, LBM yüzdesinde bir azalma kaydedildi. LBM yüzdesindeki azalmaya rağmen, LBM tedavi süresince arttığından, GnRHa tedavisi altında kas gücünde bir artış gözlendi. Ayrıca, GnRHa tedavisi sırasında PBF'deki değişim, başlangıç ​​PBF durumuna bağlı olarak farklılıklar gösterdi.

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Cite This Article

Donbaloğlu, Z., Singin, B., Çetiner, E. B., Bedel, A., Behram, B. A., Çetin, K., Tuhan, H., Parlak, M. (2025). Changes in body composition and muscle strength in girls with idiopathic central precocious puberty during gonadotropin-releasing hormone agonist therapy. Journal of Health Sciences and Medicine, Volume: 8 Issue: 1. https://doi.org/10.32322/jhsm.1557045

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