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Journals / Journal of Health Sciences and Medicine / 2026 / Volume: 8 Issue: 5

Diagnostic adequacy of thyroid fine needle aspiration biopsy: a comparative analysis by age and gender

Tiroid ince iğne aspirasyon biyopsisinin tanısal yeterliliği: yaş ve cinsiyete göre karşılaştırmalı analiz

Erkan Bilgin(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-2054-1571
Ahmet Bayrak(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0002-2150-8650
Pages
—
Publication Date
2025-09-16
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings highlight the need for optimized biopsy strategies in older populations to enhance diagnostic yield.

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: To evaluate the diagnostic success of thyroid fine needle aspiration biopsy (FNAB) across different age and gender groups, and to investigate the effect of aging and sex-related variables on biopsy adequacy.
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Key Findings & Data:Methods: This retrospective study included 486 patients who underwent thyroid FNAB between 2022 and 2024.
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Conclusion & Impact:These findings highlight the need for optimized biopsy strategies in older populations to enhance diagnostic yield.
🔬Design:Research Article
📍Scope:2022 Verileri
⚙️Variables:Thyroid nodule · biopsy · fine-needle

Abstract

Aims: To evaluate the diagnostic success of thyroid fine needle aspiration biopsy (FNAB) across different age and gender groups, and to investigate the effect of aging and sex-related variables on biopsy adequacy. Methods: This retrospective study included 486 patients who underwent thyroid FNAB between 2022 and 2024. Patients were stratified into two age groups ( 0.05), but advanced age was associated with reduced adequacy, potentially due to structural tissue changes or technical limitations. Conclusion: The diagnostic performance of thyroid FNAB diminishes significantly with age, especially in elderly male patients. Gender does not appear to be an independent determinant. These findings highlight the need for optimized biopsy strategies in older populations to enhance diagnostic yield.

Özet

Amaç: Tiroid ince iğne aspirasyon biyopsisinin (FNAB) farklı yaş ve cinsiyet gruplarında tanısal başarısını değerlendirmek ve yaşlanma ve cinsiyete bağlı değişkenlerin biyopsi yeterliliği üzerindeki etkisini araştırmak. Yöntemler: Bu retrospektif çalışmaya 2022-2024 yılları arasında tiroid FNAB'si yapılan 486 hasta dahil edildi. Hastalar iki yaş grubuna ( 0,05), ancak ileri yaş, potansiyel olarak yapısal doku değişiklikleri veya teknik kısıtlamalar nedeniyle azalmış yeterlilikle ilişkilendirildi. Sonuç: Tiroid FNAB'nin tanısal performansı yaşla birlikte önemli ölçüde azalır, özellikle yaşlı erkek hastalarda. Cinsiyet bağımsız bir belirleyici gibi görünmüyor. Bu bulgular, tanısal verimi artırmak için yaşlı popülasyonlarda optimize edilmiş biyopsi stratejilerine olan ihtiyacı vurgulamaktadır.

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Cite This Article

Bilgin, E., Bayrak, A. (2025). Diagnostic adequacy of thyroid fine needle aspiration biopsy: a comparative analysis by age and gender. Journal of Health Sciences and Medicine, Volume: 8 Issue: 5. https://doi.org/10.32322/jhsm.1706182

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References (20)

  1. Gharib H, Papini E, Garber JR, et al. American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi Medical guidelines for clinical practice for the diagnosis and management of thyroid nodules-2016 update. Endocr Pract. 2016;22(5):622-639. doi:10.4158/EP161208.GL
  2. Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1-133. doi:10.1089/thy.2015.0020
  3. Mazzaferri EL. Management of a solitary thyroid nodule. N Engl J Med. 1993;328(8):553-559. doi:10.1056/NEJM199302253280807
  4. Guth S, Theune U, Aberle J, Galach A, Bamberger CM. Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examination. Eur J Clin Invest. 2009;39(8):699-706. doi:10. 1111/j.1365-2362.2009.02162.x
  5. Poma AM, Macerola E, Basolo A, et al. Fine-needle aspiration cytology and histological types of thyroid cancer in the elderly: evaluation of 9070 patients from a single referral centre. Cancers (Basel). 2021;13:4. doi:10.3390/cancers13040907
  6. Kwong N, Medici M, Angell TE, et al. The influence of patient age on thyroid nodule formation, multinodularity, and thyroid cancer risk. J Clin Endocrinol Metab. 2015;100(12):4434-4440. doi:10.1210/jc.2015-3100
  7. Ospina NS, Papaleontiou M. Thyroid Nodule evaluation and management in older adults: a review of practical considerations for clinical endocrinologists. Endocr Pract. 2021;27(3):261-268. doi:10.1016/ j.eprac.2021.02.003
  8. Cibas ES, Ali SZ, Conference NCITFSotS. The Bethesda system for reporting thyroid cytopathology. Am J Clin Pathol. 2009;132(5):658-665. doi:10.1309/AJCPPHLWMI3JV4LA
  9. Baloch ZW, LiVolsi VA, Asa SL, et al. Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol. 2008;36(6):425-437. doi: 10.1002/dc.20830
  10. Frates MC, Benson CB, Charboneau JW, et al. Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. Radiology. 2005;237(3):794-800. doi:10.1148/radiol.2373050220
  11. Belfiore A, Giuffrida D, La Rosa GL, et al. High frequency of cancer in cold thyroid nodules occurring at young age. Acta Endocrinol (Copenh). 1989;121(2):197-202. doi:10.1530/acta.0.1210197
  12. Yoon JH, Lee HS, Kim EK, Moon HJ, Kwak JY. Malignancy risk stratification of thyroid nodules: comparison between the thyroid imaging reporting and data system and the 2014 American Thyroid Association management guidelines. Radiology. 2016;278(3):917-924. doi:10.1148/radiol.2015150056
  13. Bongiovanni M, Spitale A, Faquin WC, Mazzucchelli L, Baloch ZW. The Bethesda system for reporting thyroid cytopathology: a meta-analysis. Acta Cytol. 2012;56(4):333-339. doi:10.1159/000339959
  14. Trimboli P, Giovanella L. Reliability of core needle biopsy as a second-line procedure in thyroid nodules with an indeterminate fine-needle aspiration report: a systematic review and meta-analysis. Ultrasonography. 2018;37(2):121-128. doi:10.14366/usg.17066
  15. Rossi ED, Bizzarro T, Martini M, et al. The role of fine-needle aspiration in the thyroid nodules of elderly patients. Oncotarget. 2016;7(11):11850-11859. doi:10.18632/oncotarget.7643
  16. Jeong EJ, Chung SR, Baek JH, Choi YJ, Kim JK, Lee JH. A comparison of ultrasound-guided fine needle aspiration versus core needle biopsy for thyroid nodules: pain, tolerability, and complications. Endocrinol Metab (Seoul). 2018;33(1):114-120. doi:10.3803/EnM.2018.33.1.114
  17. Shin JH. Strategies for safe and effective core needle biopsy of thyroid nodules with macrocalcification. Int J Thyroidol. 2023;16(2):195-199.
  18. Aysan E, Guler B, Kiran T, Idiz UO. Core needle biopsy in the diagnosis of thyroid nodules. Am Surg. 2023;89(12):5170-5174. doi:10.1177/00031348221142570
  19. Atmış VEÖ, B. Comparison of the results of thyroidectomy and second fine-needle aspiration biopsy of the old age group with the previous Bethesda III group: is the second biopsy necessary. Erciyes Med J. 2020; 42(1):25-29. doi:10.14744/etd.2019.80378
  20. Yim Y, Baek JH. Core needle biopsy in the management of thyroid nodules with an indeterminate fine-needle aspiration report. Gland Surg. 2019;8(Suppl 2):S77-S85. doi:10.21037/gs.2018.09.07