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Journals / Journal of Health Sciences and Medicine / 2025 / Volume: 8 Issue: 6

Role of first trimester inflammatory markers in predicting adverse obstetric and neonatal outcomes in maternal obesity

Maternal obezitede olumsuz obstetrik ve neonatal sonuçların tahmininde ilk trimester inflamatuar belirteçlerinin rolü

Betül Akgün Aktaş(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ)0000-0003-4523-011X
Emre Gençaslan(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ)0009-0000-3548-3741
Ezgi Başaran(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, KAYSERİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-5062-3316
Ayşe Altındiş Bal(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ESKİŞEHİR ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ)0009-0003-3471-8205
Burcu Bozkurt Özdal(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ESKİŞEHİR ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ)0009-0007-6644-3890
Fatma Doğa Öcal(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ESKİŞEHİR ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ)0000-0003-4727-7982
Dilek Şahin(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ESKİŞEHİR ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ)0000-0001-8567-9048
Pages
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Publication Date
2025-10-25
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In ROC analysis, it was found that the levels of inflammatory markers to predict adverse obstetric and neonatal outcomes in obese pregnant women were statistically significant.

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: To compare first trimester serum inflammatory markers in obese pregnant women with healthy pregnant women and to investigate the predictive value of these markers for pregnancy and neonatal outcomes Methods: This prospective observational study included 46 pregnant women with maternal obesity and 60 healthy pregnant women without obesity.
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Key Findings & Data:To evaluate the predictive value for neonatal intensive care unit (NICU) admission and adverse obstetric outcomes, receiver operating characteristic curves were generated and the area under the curve values were calculated.
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Conclusion & Impact:In ROC analysis, it was found that the levels of inflammatory markers to predict adverse obstetric and neonatal outcomes in obese pregnant women were statistically significant.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Obesity · pregnancy · systemic inflammation index

Abstract

Aims: To compare first trimester serum inflammatory markers in obese pregnant women with healthy pregnant women and to investigate the predictive value of these markers for pregnancy and neonatal outcomes Methods: This prospective observational study included 46 pregnant women with maternal obesity and 60 healthy pregnant women without obesity. The demographic characteristics, obstetric and neonatal outcomes of the participants were evaluated, and the neutrophil-lymphocyte ratio (NLR), systemic inflammation index (SII: NLR*platelet), systemic inflammation response index (SIRI: NLR*monocyte), aggregate index of systemic inflammation (AISI: NLR*platelet count*monocyte), and PLR (platelet-lymphocyte ratio) were calculated. To evaluate the predictive value for neonatal intensive care unit (NICU) admission and adverse obstetric outcomes, receiver operating characteristic curves were generated and the area under the curve values were calculated. Results: The demographic characteristics of both groups were similar. In the study group, adverse obstetric outcomes, and NICU requirement were increased. In the maternal obese group, inflammatory markers such as SII, SIRI, AISI, and NLR were significantly elevated. PLR was also increased in the study group. In ROC analysis, it was found that the levels of inflammatory markers to predict adverse obstetric and neonatal outcomes in obese pregnant women were statistically significant. Conclusion: SII, SIRI, AISI, PLR, and NLR may be helpful in predicting neonatal and obstetric outcomes in maternal obesity.

Özet

Amaç: Obez gebelerde ilk trimester serum inflamatuvar markerlarını sağlıklı gebeler ile karşılaştırmak ve bu markerların gebelik ile neonatal sonuçları öngörmesini incelemek Metod: Bu çalışma, prospektif bir gözlemsel çalışma olup çalışma grubuna 46 obez gebe ile kontrol grubu ise sağlıklı 60 gebeden oluşturulmuştur. Katılımcıların demografik özellikleri, obstetrik ve neonatal sonuçları değerlendirilmiş olup nötrofil-lenfosit oranı (NLR), ile sistemik inflamasyon indeks (SII: NLR*platelet sayısı), sistemik inflamasyon response indeks (SIRI: NLR*monosit sayısı), sistemik inflamasyon agregat indeksi (AISI: NLR* platelet sayısı * monosit sayısı), PLR (platelet-lenfosit oranı) hesaplanmıştır. Yenidoğan yoğun bakım ihtiyacı (NICU) ve kötü obstetrik sonuçlaro öngörmeyi değerlendirmek için Alıcı İşletim Karakteristiği (ROC) eğrileri oluşturuldu ve eğri altındaki alan değerleri standart yöntemler kullanılarak hesaplandı. Bulgular: Her iki grubunda demografik özellikleri benzerdi. Çalışma grubunda acil sezaryan, kötü obstetrik sonuç ve NICU ihtiyacı fazlaydı. Obez grupta inflamatuvar marker olan beyaz kan hücre sayımı ile nötrofil ve monosit, platelet sayımı yüksek bulundu. Ayrıca maternal obez grupta SII, SIRI, AISI, NLR istatistiksel anlamlı yüksekti. Ayrıca, PLR ise çalışma grubunda kontrol grubuna göre bulundu. ROC analizinde, obez gebelerde kötü obstetrik sonuçları öngörme kapasitesinin SII ve AISI için istatistiksel olarak anlamlı olduğu görüldü. Sonuç: Maternal obezitede neonatal ve obstetrik sonuçları öngörmede SII, SIRI, AISI, PLR ve NLR yardımcı olabilir.

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Cite This Article

Aktaş, B. A., Gençaslan, E., Başaran, E., Bal, A. A., Özdal, B. B., Öcal, F. D., Şahin, D. (2025). Role of first trimester inflammatory markers in predicting adverse obstetric and neonatal outcomes in maternal obesity. Journal of Health Sciences and Medicine, Volume: 8 Issue: 6. https://doi.org/10.32322/jhsm.1783426

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