AI Summary & Key Takeaways
AI InsightHowever, the observed relationships between vit B12 levels and RDW and albumin suggest the presence of complex metabolic interactions that require further investigation in prospective, multicenter studies.
📌 3 Key Takeaways
Abstract
Aims: Vitamin B12 (Vit B12) plays important role in immune modulation. We aimed to compare clinical outcomes, laboratory findings, and survival rates among coronavirus disease 2019 (COVID-19) patients admitted to the intensive care unit (ICU) based on their vit B12 levels and to identify factors associated with mortality. Methods: This retrospective study examined ICU patients with COVID-19. Patients were categorized into three groups according to their vit B12 levels at ICU admission: normal (Vit B12-N), low (Vit B12-L) and high (Vit B12). The groups were compared in terms of patient characteristics, laboratory parameters, and survival outcomes. Additionally, the characteristics and laboratory values of the entire cohort were analyzed based on survival status. Results: A total of 665 patients were included (Vit B12-N: 539; Vit B12-L: 39; Vit B12-H: 87). There were no differences in disease severity, clinical characteristics, length of stay, and mortality between the groups (p>0.05). The high vit B12 group showed higher RDW and lower albumin levels compared with the normal vit B12 group (p<0.05). A higher Acute Physiology and Chronic Health Evaluation (APACHE) II score was found to be independently associated with increased mortality (p=0.000). Conclusion: Serum vit B12 levels at ICU admission were not associated with disease severity, clinical outcomes, or survival in critically ill patients with COVID-19. APACHE II score was the only variable independently associated with mortality. However, the observed relationships between vit B12 levels and RDW and albumin suggest the presence of complex metabolic interactions that require further investigation in prospective, multicenter studies.