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Journals / Journal of Health Sciences and Medicine / 2026 / Volume: 9 Issue: 4

Triglyceride–Glucose Index and Atherogenic Index of plasma in migraine: a cross-sectional study of cardiometabolic surrogate markers

Deniz Kamacı Şener(BURSA ŞEHİR HASTANESİ)0000-0003-3433-6859
Şenay Fırat(Bursa Şehir Hastanesi)0000-0002-0011-8661
Özden Kamışlı(Bursa Şehir Hastanesi)0000-0003-1114-7860
Pages
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Publication Date
2026-07-20
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These surrogate indices may contribute to a better understanding of the relationship between migraine and cardiometabolic pathways.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aims: Migraine is a common neurological disorder that has been associated with various metabolic and cardiovascular conditions.
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Key Findings & Data:Methods: This retrospective cross-sectional study included adult patients diagnosed with migraine according to the International Classification of Headache Disorders, 3rd edition (ICHD-3).
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Conclusion & Impact:These surrogate indices may contribute to a better understanding of the relationship between migraine and cardiometabolic pathways.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Migraine · Atherogenic Index of Plasma · Triglyceride-Glucose Index

Abstract

Aims: Migraine is a common neurological disorder that has been associated with various metabolic and cardiovascular conditions. The Triglyceride-Glucose (TyG) Index and the Atherogenic Index of Plasma (AIP) are practical markers used to assess insulin resistance and cardiometabolic risk. This study aimed to evaluate TyG and AIP levels in patients with migraine and compare them with healthy controls. Methods: This retrospective cross-sectional study included adult patients diagnosed with migraine according to the International Classification of Headache Disorders, 3rd edition (ICHD-3). Demographic and clinical data, along with laboratory parameters, were recorded. TyG Index and AIP values were calculated and compared with those of age- and sex-matched healthy individuals. Results: TyG Index and AIP values were significantly higher in patients with migraine compared to controls. Glucose and TyG levels were highest in patients with chronic migraine. In the episodic migraine group, both indices were positively correlated with BMI, whereas TyG also showed a positive correlation with age. Conclusion: Elevated TyG and AIP values in patients with migraine may reflect underlying cardiometabolic alterations and vascular susceptibility. These surrogate indices may contribute to a better understanding of the relationship between migraine and cardiometabolic pathways.

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Cite This Article

Şener, D. K., Fırat, Ş., Kamışlı, Ö. (2026). Triglyceride–Glucose Index and Atherogenic Index of plasma in migraine: a cross-sectional study of cardiometabolic surrogate markers. Journal of Health Sciences and Medicine, Volume: 9 Issue: 4. https://doi.org/10.32322/jhsm.1939967

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References (33)

  1. Ferrari MD, Goadsby PJ, Burstein R, et al. Migraine. Nat Rev Dis Primers. 2022;8(1):2. doi:10.1038/s41572-021-00328-4
  2. Steiner TJ, Stovner LJ, Jensen R, et al. Migraine remains second among the world’s causes of disability, and first among young women: findings from GBD2019. J Headache Pain. 2020;21(1):137. doi:10.1186/s10194-020-01208-0
  3. Adelborg K, Szépligeti SK, Holland-Bill L, et al. Migraine and risk of cardiovascular diseases: Danish population based matched cohort study. BMJ. 2018;360:k96. doi:10.1136/bmj.k96
  4. Kurth T, Winter AC, Eliassen AH, et al. Migraine and risk of cardiovascular disease in women: prospective cohort study. BMJ. 2016;353:i2610. doi:10.1136/bmj.i2610
  5. Glintborg D, Andersen M. Management of endocrine disease: morbidity in polycystic ovary syndrome. Eur J Endocrinol. 2017;176(2):R53-R65. doi:10.1530/EJE-16-0907
  6. Rainero I, Limone P, Ferrero M, et al. Insulin sensitivity is impaired in patients with migraine. Cephalalgia. 2005;25(8):593-597. doi:10.1111/j.1468-2982.2005.00913.x
  7. Lima Carvalho MF, de Medeiros JS, Valença MM. Headache in recent onset hypothyroidism: prevalence, characteristics and outcome after treatment with levothyroxine. Cephalalgia. 2017;37(10):938-946. doi:10.1177/0333102416660553
  8. Buse DC, Manack A, Serrano D, et al. Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. J Neurol Neurosurg Psychiatry. 2010;81(4):428-432. doi:10.1136/jnnp.2009.192492
  9. Hoffmann U, Sukhotinsky I, Eikermann-Haerter K, et al. Glucose modulation of spreading depression susceptibility. J Cereb Blood Flow Metab. 2013;33(2):191-195. doi:10.1038/jcbfm.2012.166
  10. Luo E, Wang D, Yan G, et al. High Triglyceride-Glucose Index is associated with poor prognosis in patients with acute ST-elevation myocardial infarction after percutaneous coronary intervention. Cardiovasc Diabetol. 2019;18:150. doi:10.1186/s12933-019-0957-2
  11. Dobiasova M. AIP-Atherogenic Index of plasma as a significant predictor of cardiovascular risk: from research to practice. Vnitr Lek. 2006;52(1):64-71.
  12. Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008;6(4):299-304. doi:10.1089/met.2008.0034
  13. Reyes-Ferrada W, Solis-Urra P, Plaza-Díaz J, et al. Cardiorespiratory fitness, physical activity, sedentary time and its association with the Atherogenic Index of Plasma in Chilean adults: influence of the waist circumference-to-height ratio. Nutrients. 2020;12(5):1250. doi:10.3390/nu12051250
  14. Niroumand S, Khajedaluee M, Khadem-Rezaiyan M, et al. Atherogenic Index of Plasma (AIP): a marker of cardiovascular disease. Med J Islam Repub Iran. 2015;29:240.
  15. Gross EC, Lisicki M, Fischer D, et al. The Metabolic Face of Migraine. Frontiers Media SA; 2019.
  16. Ali M, Hussein M, Magdy R, et al. The potential impact of insulin resistance and metabolic syndrome on migraine headache characteristics. BMC Neurol. 2022;22(1):422. doi:10.1186/s12883-022-02966-8
  17. Fava A, Pirritano D, Consoli D, et al. Chronic migraine in women is associated with insulin resistance: a cross-sectional study. Eur J Neurol. 2014;21(2):267-272. doi:10.1111/ene.12289
  18. Jin JL, Cao YX, Wu LG, et al. Triglyceride Glucose Index for predicting cardiovascular outcomes in patients with coronary artery disease. J Thorac Dis. 2018;10(11):6137-6146. doi:10.21037/jtd.2018.10.79
  19. Scher AI, Terwindt GM, Picavet HSJ, et al. Cardiovascular risk factors and migraine: the GEM population-based study. Neurology. 2005;64(4): 614-620. doi:10.1212/01.WNL.0000151857.43225.49
  20. Langsted A, Freiberg JJ, Nordestgaard BG. Fasting and nonfasting lipid levels: influence of normal food intake on lipids, lipoproteins, apolipoproteins, and cardiovascular risk prediction. Circulation. 2008;118(20):2047-2056. doi:10.1161/CIRCULATIONAHA.108.804146
  21. Varbo A, Benn M, Tybjærg-Hansen A, Nordestgaard BG. Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation. Circulation. 2013;128(12):1298-1309. doi:10.1161/CIRCULATIONAHA.113.003008
  22. Won KB, Kim HJ, Cho JH, et al. Different association of Atherogenic Index of Plasma with the risk of high platelet reactivity according to the presentation of acute myocardial infarction. Sci Rep. 2024;14(1):10894. doi:10.1038/s41598-024-61492-6
  23. Garg R, Knox N, Prasad S, et al. The Atherogenic Index of Plasma is independently associated with symptomatic carotid artery stenosis. J Stroke Cerebrovasc Dis. 2020;29(12):105351. doi:10.1016/j.jstrokecerebrovasdis. 2020.105351
  24. Liu Y, Feng X, Yang J, et al. The relation between Atherogenic Index of Plasma and cardiovascular outcomes in prediabetic individuals with unstable angina pectoris. BMC Endocr Disord. 2023;23(1):187. doi:10.1186/s12902-023-01442-7
  25. Gruber HJ, Bernecker C, Pailer S, et al. Lipid profile in normal weight migraineurs-evidence for cardiovascular risk. Eur J Neurol. 2010;17(3):419-425. doi:10.1111/j.1468-1331.2009.02813.x
  26. Rist PM, Tzourio C, Kurth T. Associations between lipid levels and migraine: cross-sectional analysis in the epidemiology of vascular ageing study. Cephalalgia. 2011;31(14):1459-1465. doi:10.1177/0333102411423302
  27. Winsvold BS, Hagen K, Aamodt AH, et al. Headache, migraine and cardiovascular risk factors: the HUNT study. Eur J Neurol. 2011;18(3): 504-511. doi:10.1111/j.1468-1331.2010.03133.x
  28. Guldiken B, Guldiken S, Taskiran B, et al. Migraine in metabolic syndrome. Neurologist. 2009;15(2):55-58. doi:10.1097/NRL.0b013e31818a6b36
  29. Bhoi SK, Kalita J, Misra UK. Metabolic syndrome and insulin resistance in migraine. J Headache Pain. 2012;13(4):321-326. doi:10.1007/s10194-012-0440-1
  30. Zola KV, da Silva JKKV, Lima Filho JB, et al. Association of altered serum glucose and lipid profiles with headaches in young women: clinical, cross-sectional study. Headache Med. 2023;14(4):214-220. doi:10.48208/HeadacheMed.2023.42
  31. Tana C, Santilli F, Martelletti P, et al. Correlation between migraine severity and cholesterol levels. Pain Pract. 2015;15(7):662-670. doi:10.1111/papr.12213
  32. Assempoor R, Daneshvar MS, Taghvaei A, et al. Atherogenic Index of Plasma and coronary artery disease: a systematic review and meta-analysis of observational studies. Cardiovasc Diabetol. 2025;24(1):35. doi:10.1186/s12933-025-02550-5
  33. Moussavi Javardi MS, Madani Z, Movahedi A, et al. The correlation between dietary fat quality indices and lipid profile with Atherogenic Index of Plasma in obese and non-obese volunteers: a cross-sectional descriptive-analytic case-control study. Lipids Health Dis. 2020;19:213. doi:10.1186/s12944-020-01387-4