SavedAdd your journal

Journals / E Journal of Cardiovascular Medicine / 2020 / Cilt: 8 - Sayı: 2

How Much Do Routine Blood Tests Tell Us About Patent Ductus Arteriosus? Is the Red Cell Distribution Width to Platelet Count Ratio or/and Any Platelet Parameter Useful?

Birol KARABULUT
Ayşe ŞİMŞEK FIRAK
Pages
91–98
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: None of platelet count, PDW, mean platelet volume, or Platelet Mass index can be used to predict either hsPDA or treatment success, but a low PCT, and a high RDW and RPR, predict hsPDA but not treatment success.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: In this observational study, to determine whether there is any association between red cell distribution width (RDW)/platelet count ratio (RPR) and hemodynamically significant patent ductus arteriosus (hsPDA) in preterms.
📊
Key Findings & Data:Materials and Methods: A total of 233 preterm infants, gestational age <34 weeks were analyzed in the study.
💡
Conclusion & Impact:Conclusion: None of platelet count, PDW, mean platelet volume, or Platelet Mass index can be used to predict either hsPDA or treatment success, but a low PCT, and a high RDW and RPR, predict hsPDA but not treatment success.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: In this observational study, to determine whether there is any association between red cell distribution width (RDW)/platelet count ratio (RPR) and hemodynamically significant patent ductus arteriosus (hsPDA) in preterms. Materials and Methods: A total of 233 preterm infants, gestational age <34 weeks were analyzed in the study. Complete blood counts obtained at 24th h, 48th h, 72nd h and 7th days were evaluated for RDW, RPR, platelet parameters and compared for PDA status. Results: Our study included 64 infants with hsPDA and 64 controls. The RDW at 48th h, 72nd h, and 7th day and the RPR at 24th h, 48th h, 72nd h and 7th day were significantly higher in the study compared to the control group; the PCT was lower. The RPR afforded 72.3-79.2% sensitivity and 82.3-89.2% specificity when used to predict hsPDA. Conclusion: None of platelet count, PDW, mean platelet volume, or Platelet Mass index can be used to predict either hsPDA or treatment success, but a low PCT, and a high RDW and RPR, predict hsPDA but not treatment success.

🔖

Cite This Article

KARABULUT, B., FIRAK, A. Ş. (2020). How Much Do Routine Blood Tests Tell Us About Patent Ductus Arteriosus? Is the Red Cell Distribution Width to Platelet Count Ratio or/and Any Platelet Parameter Useful?. E Journal of Cardiovascular Medicine, Cilt: 8 - Sayı: 2, 91–98. https://ajindex.com/articles/149902

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Clyman RI. Mechanisms regulating the ductus arteriosus. Biol Neonate 2006;89:330-5
  2. Weinberg JG, Evans FJ, Burns KM, Pearson GD, Kaltman JR. Surgical ligation of patent ductus arteriosus in premature infants: trends and practice variation. Cardiol Young 2016;26:1107-14
  3. Mirea L, Sankaran K, Seshia M, et al. Treatment of patent ductus arteriosus and neonatal mortality/morbidities: Adjustment for treatment selection bias. J Pediatr 2012;161:689-94.e1
  4. Sehgal A, McNamara PJ. The ductus arteriosus: A refined approach!. Semin Perinatol 2012;36:105-13
  5. Evans N. Preterm patent ductus arteriosus: A contnuing conundrum for the neonatologist?. Semin Fetal Neonatal Med 2015;20:272-7
  6. Smith A, McNamara PJ, El-Khuffash AF. Non-pharmacological management of a hemodynamically significant patent ductus arteriosus. Semin Fetal Neonatal Med 2018;23:245-9
  7. Huang HS, Chang HH. Platelets in inflammation and immune modulations: functions beyond hemostasis. Arch Immunol Ther Exp (Warsz) 2012;60:443-51
  8. Leslie M. Cell biology. Beyond clotting: the powers of platelets. Science 2010;328:562-4
  9. Echtler K, Stark K, Lorenz M, et al. Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med 2010;16:75-82
  10. Dani C, Poggi C, Fontanelli G. Relationship between platelet count and volume and spontaneous and pharmacological closure of ductus arteriosus in preterm infants. Am J Perinatol 2013;30:359-64
  11. Shah NA, Hills NK, Waleh N, et al. Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment. J Pediatr 2011;158:919-23.e1-2
  12. Akar S, Karadag N, Yildirim TG, et al. Does platelet mass influence the effectiveness of ibuprofen treatment for patent ductus arteriosus in preterm infants?. J Matern Fetal Neonatal Med 2016;29:3786-9
  13. Kahvecioglu D, Erdeve O, Akduman H, et al. Influence of platelet count, platelet mass index, and platelet function on the spontaneous closure of ductus arteriosus in the prematurity. Pediatr Neonatol 2018;59:53-7
  14. Wu X, Cai B, Su Z, Li Y, Xu J, Deng R, et al. Aspartate transaminase to platelet ratio index and gamma-glutamyl transpeptidase-to-platelet ratio outweigh fibrosis index based on four factors and red cell distribution width-platelet ratio in diagnosing liver fibrosis and inflammation in chronic hepatitis B. J Clin Lab Anal 2018;32:e22341
  15. Chen YP, Hu XM, Liang XE, Huang LW, Zhu YF, Hou JL. Stepwise application of fibrosis index based on four fa