Journals / ANKEM Dergisi / 2014 / Cilt: 28 - Sayı: 2

Frequency and Antibiotic Susceptibility of Moraxella catarrhalis Isolated from Sputum in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

KRONİK OBSTRÜKTİF AKCİĞER HASTALIĞININ AKUT ALEVLENMELERİNDE BALGAMDAN İZOLE EDİLEN MORAXELLA CATARRHALIS SIKLIĞI VE ANTİBİYOTİK DUYARLILIĞI

Pages
44–49
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results obtained were in correlation with the data reported f rom the world and Turkey.

📌 3 Key Takeaways

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Objective & Hypothesis:Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease that can lead to morbidity and morta- lity which also can have acute exacerbations.
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Key Findings & Data:In our study, the isolation rate, beta lactamase activity and antibiotic suscepti- bility of Moraxella catarrhalis, one of the most common agents causing COPD exacerbations, is assessed.
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Conclusion & Impact:Results obtained were in correlation with the data reported f rom the world and Turkey.
🔬Design:Research Article
📍Scope:2009 Verileri
⚙️Variables:Domain Parameters

Abstract

Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease that can lead to morbidity and morta- lity which also can have acute exacerbations. In our study, the isolation rate, beta lactamase activity and antibiotic suscepti- bility of Moraxella catarrhalis, one of the most common agents causing COPD exacerbations, is assessed. A hundred and twenty-f our voluntary COPD patients diagnosed with acute exacerbation who were ref erred to Pulmonary Disease and Tuberculosis Department of Izzet Baysal Research Hospital and Abant Izzet Baysal University Medical Faculty during the time period of October 2009 to March 2010 were included the study. Bacteria isolated f rom sputum cultures were identif ied by conventional microbiological methods and API NH test kit. Agar dilution test and E-test method were used f or antibiotic susceptibility testing and nitrocephin test was used f or testing beta-lactamase production. In 50 of the 98 cultured sputum specimens, 51 pathogenic microorganisms were detected. Fif teen percent % of these bacteria were Streptococcus pneumoniae (n:15), 11.2 % were Pseudomonas aeruginosa (n:11), 10.2 % were Moraxella catarrhalis (n:10), 6.1 % were Haemophilus inf luenzae (n:6), 3 % were Escherichia coli (n:3) 3 % were Klebsiella pneumoniae (n:3) and 3 % were Haemophilus parainf - luenzae (n:3). In one patient’s sputum culture, two pathogenic bacteria were isolated (M.catarrhalis and H.inf luenzae). Beta- lactamase test was positive in nine of the 10 M.catarrhalis strains. No resistance was detected aganist erythromycin, tetracy- cline, ciprof loxacin, cef uroxime and cef triaxone. Resistance aganist trimethoprim-sulf amethoxazole was 10 % and the resis- tance aganist ampicillin was 90 %. Results obtained were in correlation with the data reported f rom the world and Turkey.

Özet

Kronik obstrüktif akciğer hastalığı (KOAH), morbidite ve mortaliteye neden olan progresif , kronik seyirli ve akut alev- lenmelerle seyreden bir hastalıktır. Çalışmamızda KOAH alevlenmelerinde sık görülen etkenlerden olan Moraxella catarrhalis’in izolasyon oranı, beta-laktamaz aktivitesi ve antibiyotik duyarlılıkları araştırılmıştır. Çalışmaya, Ekim 2009- Mart 2010 tarihleri arasında Abant İzzet Baysal Üniversitesi Tıp Fakültesi ve İzzet Baysal Devlet Hastanesi Göğüs Hastalıkları ve Tüberküloz Bölümü’ne başvuran, KOAH alevlenmesi tanısı alan 124 gönüllü hasta alınmıştır. Hastalardan alınan balgam örneklerinde üreyen bakteriler konvansiyonel mikrobiyolojik yöntemler ve API NH test kiti ile tanımlanmıştır. Antibiyotik duyarlılık testleri için agar dilüsyon testi ve E-test yöntemi, beta-laktamaz aktivitesi için nitrosef in testi kullanıl- mıştır. Kültürü yapılan 98 balgam örneğinin 50’sinde patojen kabul edilen 51 mikroorganizma üremiştir. Bu bakterilerin % 15’i Streptococcus pneumoniae (n:15), % 11.2’si Pseudomonas aeruginosa (n:11), % 10.2’si Moraxella catarrhalis (n:10), % 6.1’i Haemophilus inf luenzae (n:6), % 3’ü Escherichia coli (n:3), % 3’ü Klebsiellae pneumoniae (n:3) ve, % 3’ü Haemophilus parainf luenzae (n:3) olarak bulunmuştur. Bir hastanın balgam kültüründe patojen olarak bilinen iki bakteri (M.catarrhalis ve H.inf luenzae) birlikte üretilmiştir. İzole edilen on M.catarrhalis suşlarının dokuzunda beta-laktamaz testi pozitif olarak sap- tanmıştır. Eritromisin, tetrasiklin, siprof loksasin, sef uroksim ve sef triaksona karşı direnç görülmemiştir. Trimetoprim- sülf a- metoksazol direnci % 10, ampisilin direnci % 90 olarak belirlenmiştir. Elde edilen sonuçlar dünya ve ülkemiz verileri ile uyumlu bulunmuştur.

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Cite This Article

İNCE, N., SIRMATEL, F. (2014). Frequency and Antibiotic Susceptibility of Moraxella catarrhalis Isolated from Sputum in Acute Exacerbation of Chronic Obstructive Pulmonary Disease. ANKEM Dergisi, Cilt: 28 - Sayı: 2, 44–49. https://ajindex.com/articles/149332

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