Journals / Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi / 2020 / Cilt: 34 - Sayı: 1

ANTIVENOMS AND PRINCIPLES OF APPLICATION

Antivenomlar ve uygulama ilkeleri

Pages
73–83
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, antivenom practice principles in animal bites and stings in Turkey will be discussed in general.

📌 3 Key Takeaways

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Objective & Hypothesis:Venomous animals bites, stings, and poisoning are major public health problem in the developing countries.
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Key Findings & Data:At least 1.8-2.7 million snake bite cases are reported annually around the world and between 81,000 and 137,000 deaths have been reported.
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Conclusion & Impact:In this review, antivenom practice principles in animal bites and stings in Turkey will be discussed in general.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:akrep sokmaları · örümcek ısırmaları · antivenom

Abstract

Venomous animals bites, stings, and poisoning are major public health problem in the developing countries. At least 1.8-2.7 million snake bite cases are reported annually around the world and between 81,000 and 137,000 deaths have been reported. Scorpion sting was reported in similar proportions as snake bites, and the mortality rate in the reported cases was significantly lower than in snake bites. Antivenoms are antibody preparations produced against venom of venomous animals. The antivenoms have been produced since the nineteenth century. However, it is suggested that the data obtained cannot be extrapolated to all poisonings due to controversial findings about the efficacy of antivenoms, allergic reactions of antivenoms use such as anaphylaxis and the lack of randomized controlled trials on antivenoms. There are antivenoms produced against snake bites and scorpion stings in Turkey, but no antivenoms against spider bites. It is observed that antivenoms are used inappropriately due to lack of education related to poisonings and their treatment. Thus, it is important to update the information about the use of antivenoms in the management of bites and stings. In this review, antivenom practice principles in animal bites and stings in Turkey will be discussed in general.

Özet

Zehirli hayvanlarla temas ve ısırılma nedeni ile zehirlenme ve ölüm özellikle gelişmekte olan ülkelerde bir halk sağlığı sorunudur. Dünya genelinde 1,8-2,7 milyon yılan ısırması ve 81 bin ile 137 bin arasında ölüm bildirilmiştir. Yine benzer oranlarda akrep sokması vakası bildirilmiş olup, bildirilen vakalarda ölüm oranı yılan ısırmalarına kıyasla belirgin olarak düşüktür. Antivenomlar, zehirli hayvanların venomuna karşı üretilen antikor preparatlarıdır. On dokuzuncu yüzyıldan bu yana üretilmeye başlanan antivenomların etkililiği konusunda tartışmalı bulguların olması, anaflaksi gibi alerjik reaksiyonlara neden olabilmeleri ve yapılan çalışmaların randomize kontrollü çalışmalar olmaması nedeniyle elde edilen verilerin tüm zehirlenmelere ekstrapole edilemeyeceğini düşündürmektedir. Türkiye’de yılan ısırmalarına ve akrep sokmalarına karşı üretilen antivenomlar bulunmaktadır. Ancak örümcek antivenomu bulunmamaktadır. Ayrıca, zehirlenmeler ve tedavileri ile ilgili eğitim eksikliği nedeniyle, gerekmeyen olgularda da antivenom kullanıldığı görülmektedir. Bu nedenle, ısırma ve sokmaların yönetiminde antivenom kullanımı ile ilgili bilgilerin güncellenmesi önemlidir. Bu makalede ülkemizde sık görülen yılan, akrep ve örümcek sokmalarına karşı antivenom uygulama ilkelerinden bahsedilecektir.

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Cite This Article

GÜMÜŞTEKİN, M., SARIÇOBAN, B., GÜRKAN, M. A. (2020). ANTIVENOMS AND PRINCIPLES OF APPLICATION. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, Cilt: 34 - Sayı: 1, 73–83. https://ajindex.com/articles/149124

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References (10)

  1. Warrell DA, Venomous Bites, Stings, and Poisoning: An Update. Infect Dis Clin N Am. 2019; 33:17–38
  2. Şahin A, Arıcı MA, Hocaoğlu Aksay N, Kalkan Ş, Tunçok Y. Antivenom use in bite and sting cases presenting to a public hospital. Ulus Travma Acil Cerrahi Derg. 2018;24:343-50.
  3. Arici AK, S. Hocaoglu, N. Tuncok Y. Bites and stings reported to the Dokuz Eylul University Drug and Poison Information Center. Turkish Pharmacology Association 21st National Pharmacology Congress,2011.
  4. Kasturiratne A, Wickremasinghe AR, de Silva N, The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths. PLoS Med 2008; 5: e218. Isbister GK. Antivenom efficacy or effectiveness: The Australian experience. Toxicology. 2010; 268: 148–54.
  5. Gutierrez JM, Leon G, Lomonte B. Pharmacokinetic–pharmacodynamic relationships of immunoglobulin therapy for envenomation. Clin Pharmacokinet. 2003;42:721–41. O’Leary MA, Isbister GK. Commercial monovalent antivenoms in Australia are polyvalent. Toxicon 2009; 54:192–5. Özkan Ö. Akrep antivenom üretimi. Türk Hijyen ve Deneysel Biyoloji Dergisi. 2008;65:97-108.
  6. Wang JD, Tsan YT, Yan-Chiao M, Wang LM. Venomous snakebites and antivenom treatment according to a protocol for pediatric patients in taiwan. J Venom Anim Toxins incl Trop Dis. 2009; 15: 667-79.
  7. Jayakrishnan MP, Geeta MG, Krishnakumar P, Rajesh TV, George B. Snake bite mortality in children: beyond bite to needle time. Arch Dis Child. 2016;102:445-9.
  8. Krifi MN, El Ayeb M, Dellagi K. The Improvement and Standardization of Antivenom Production in Developıng Countries: Comparing Antivenom Quality, Therapeutical Efficiency, and Cost. J Venom Anim Toxins incl Trop Dis. 1999;5:128-41.
  9. Isbister GK, Graudins A, White J, Warrell D. Antivenom treatment in arachnidism. J Toxicol Clin Toxicol. 2003;41:291-300. EMEA. The European Agency for the Evaluation of Medical Products, Evaluation of Medicines for Human Use. Note for guidance on production and quality control of animal immunoglobulins and immunosera for human use. CPMP/BWP/3354/99. London,2002. Üstünes L. İnteraktif İlaç Bilgi Kaynağı. Rx Media Pharma, 2019. Gümüştekin M. [Environmental toxins: Animal biting and stings.] T Klin J Pharmacol Toksikoloji Özel sayısı. 2003;1:53-7. Clark RF. Snakebite. In: Olson KR, ed. Poisoning and Drug Overdose. Appleton and Lange, publishing, Stamford,Connecticut; 2013. p.374-8.
  10. Baran İ, Atatür MK. [Herpetofauna of Turkey (Frog and reptiles).] TC Çevre Bakanlığı B