Journals / Cyprus Journal of Medical Sciences / 2020 / Cilt: 5 - Sayı: 2

HPV: Obvious but Not Necessary Cause of Cervical Cancer

Pages
107–112
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

RESULTS Overall, 42% (85/201) of women analysed were tested positive for at least one of the HPV types tested.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:BACKGROUND/AIMS Cervical cancer is one of the most common cancers worldwide.
📊
Key Findings & Data:MATERIAL and METHODS A total of 201 women undergoing routine gynaecological check up in Hospital were recruited.
💡
Conclusion & Impact:RESULTS Overall, 42% (85/201) of women analysed were tested positive for at least one of the HPV types tested.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

BACKGROUND/AIMS Cervical cancer is one of the most common cancers worldwide. Human papilomavirus (HPV) has been proposed to be one of the main players in the development of cervical cancer. The aim of this study was to investigate the association of HPV DNA and cervical cytology. MATERIAL and METHODS A total of 201 women undergoing routine gynaecological check up in Hospital were recruited. HPV genotyping and cervical Pap test were analysed. RESULTS Overall, 42% (85/201) of women analysed were tested positive for at least one of the HPV types tested. HPV DNA prevalence was the highest in women younger than 30 years old (59%, 50/85). Eighty four percent (71/85) of the HPV positive women had low to high grade cytological anomalies. CONCLUSION The presence of HPV DNA was strongly associated with the cytological anomalies, especially with specific HPV types. This study showed that detection of multiple HPV types is rather important in understanding the possible crosstalk among HPVs during the initiation and progression of cervical lesions. In conclusion, HPV still remains to be the most prevalent marker for cervical cancer and thus regular check up should be evaluated as a preventative policy for cervical cancer.

🔖

Cite This Article

MOCAN, G., TÜLAY, P., ÖZKAYALAR, H., SEKAKINCI, N. (2020). HPV: Obvious but Not Necessary Cause of Cervical Cancer. Cyprus Journal of Medical Sciences, Cilt: 5 - Sayı: 2, 107–112. https://ajindex.com/articles/148244

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999; 189(1): 12-9. [Crossref] 2. Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, et al. Global burden of human papillomavirus and related diseases. Vaccine 2012; 30(Suppl 5): F12-23. [Crossref] 3. Muñoz N, Bosch FX, de Sanjosé S, Herrero R, Castellsagué X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003; 348(6): 518-27. [Crossref] 4. Schiffman M, Clifford G, Buonaguro FM. Classification of weakly carcinogenic human papillomavirus types: addressing the limits of epidemiology at the borderline. Infect Agent Cancer 2009; 4: 8. [Crossref] 5. de Villiers EM, Fauquet C, Broker TR, Bernard HU, zur Hausen H. Classification of papillomaviruses. Virology 2004; 324(1): 17-27. [Crossref] 6. Bernard HU, Burk RD, Chen Z, van Doorslaer K, zur Hausen H, de Villiers EM. Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology 2010; 401(1): 70-9. [Crossref] 7. Rodríguez AC, Schiffman M, Herrero R, Hildesheim A, Bratti C, Sherman ME. Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection. J Natl Cancer Inst 2010; 102(5): 315-24. [Crossref] 8. Bosch FX, Lorincz A, Muñoz N, Meijer CJLM, Shah KV. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 2002; 55(4): 244-65. [Crossref] 9. Schiffman M, Kjaer SK. Chapter 2: Natural history of anogenital human papillomavirus infection and neoplasia. J Natl Cancer Inst Monogr 2003; (31): 14-9. [Crossref] 10. de Sanjosé S, Diaz M, Castellsagué X, Clifford G, Bruni L, Muñoz N, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis 2007; 7(7): 453-9. [Crossref] 11. Bzhalava D, Guan P, Franceschi S, Dillner J, Clifford G. A systematic review of the prevalence of mucosal and cutaneous human papillomavirus types. Virology 2013; 445(1-2): 224-31. [Crossref] 12. Zhang L, Bi Q, Deng H, Xu J, Chen J, Zhang M, et al. Human papillomavirus infections among women with cervical lesions and cervical cancer in Eastern China: genotype-specific prevalence and attribution. BMC Infect Dis 2017; 17(1): 107. [Crossref] 1