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Journals / Eurasian Journal of Food Science and Technology / 2018 / Volume: 2 Issue: 2

Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers

Nurulhünda Hancı(ATATÜRK ÜNİVERSİTESİ)
Fehmi Odabasoglu(KAFKAS ÜNİVERSİTESİ)
Fadime Atalay Dumlu(KAFKAS ÜNİVERSİTESİ)
Ozlem Aydın Berktaş(GİRESUN ÜNİVERSİTESİ)
Zerrin Kutlu(ATATURK UNIVERSITY)
Mesut Halici(ATATÜRK ÜNİVERSİTESİ)
Zekai Halici(ATATÜRK ÜNİVERSİTESİ)
Pages
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Publication Date
2018-12-29
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We determined that SO has anti-ulcerative effect and this effect are related to antioxidative properties of sesame oil.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Sesame oil (SO) is a component of the traditional health food in India as well as in oriental countries and has long been thought to possess the ability to prevent various diseases.
📊
Key Findings & Data:In this study a total of 5 rat groups were used for ulcer experiment.
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Conclusion & Impact:We determined that SO has anti-ulcerative effect and this effect are related to antioxidative properties of sesame oil.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Sesame oil · Indomethacin · Gastroprotective effect

Abstract

Sesame oil (SO) is a component of the traditional health food in India as well as in oriental countries and has long been thought to possess the ability to prevent various diseases. We examined the protective effects of sesame oil against acute gastric mucosal damage induced in rats by nonsteroidal anti-inflammatory drug indomethacin (IND). We also intended to determine the relation between antiulcer effect of SO and its antioxidant properties by biochemical evaluation. In this study a total of 5 rat groups were used for ulcer experiment. Antiulcer effects of SO have been investigated on 24 hour fasted 5 rat groups with indomethacine (IND)-induced ulcer model in the presence of positive (Famotidine, FAM), negative (untreated IND group) and intact control groups. In ulcer experiments, two doses of SO exerted significant anti-ulcerogenic effects. In gastric tissues, sesame oil administration decreased the level of LPO and activities of CAT, GR, MPO which were increased after IND application. Furthermore, SO increased the level of GSH which decreased in ulcerous stomach tissues when compared to healthy rat group. We determined that SO has anti-ulcerative effect and this effect are related to antioxidative properties of sesame oil.

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Cite This Article

Hancı, N., Odabasoglu, F., Dumlu, F. A., Berktaş, O. A., Kutlu, Z., Halici, M., Halici, Z. (2018). Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers. Eurasian Journal of Food Science and Technology, Volume: 2 Issue: 2. https://ajindex.com/articles/1482221

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