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Journals / DÜSTAD Dünya Sağlık ve Tabiat Bilimleri Dergisi / 2025 / Cilt: 8 Sayı: 1

Determination of Coagulation Tests Reference Ranges from Konya City Hospital Central Laboratory Data by Indirect Method and Investigation of Age-Dependent Changes

Konya Şehir Hastanesi Merkezi Laboratuvar Verilerinden Koagülasyon Testleri Referans Aralıklarının İndirekt Yöntemle Belirlenmesi ve Yaşa Bağımlı Değişiminin İncelenmesi

Çiğdem Damla Deniz(KONYA ŞEHİR HASTANESİ)
Sena Tayiz(Konya Şehir Hastanesi)
Mahmut Sami Tutar(KONYA ŞEHİR HASTANESİ)0000-0002-5709-6504
Hasan Basri Yıldırım(KONYA ŞEHİR HASTANESİ)
Munise Yıldız(KONYA ŞEHİR HASTANESİ)
Sami Erdem(KONYA ŞEHİR HASTANESİ)
Betül Kozanhan(KONYA ŞEHİR HASTANESİ)0000-0002-5097-9291
Deniz Yılmaz Sak(KONYA ŞEHİR HASTANESİ)
Pınar Tonbaklar(KONYA ŞEHİR HASTANESİ)
Pages
18–27
Publication Date
2025-06-26
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results indicated an INR reference range of 0.93-1.29 for all patients.

📌 3 Key Takeaways

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Objective & Hypothesis:This study aimed to establish age- and gender-specific reference ranges for activated partial thromboplastin time (aPTT), prothrombin time (PT), and the international normalized ratio (INR) using data from the Central Laboratory of Konya City Hospital.
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Key Findings & Data:The study retrospectively analyzed PT, aPTT, and INR results from patients aged 0-95 years who underwent preoperative evaluations for minor elective surgeries between August 2020 and March 2023.
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Conclusion & Impact:The results indicated an INR reference range of 0.93-1.29 for all patients.
🔬Design:Araştırma Makalesi
📍Scope:2020 Verileri
⚙️Variables:aPTT · INR · koagülasyon

Abstract

This study aimed to establish age- and gender-specific reference ranges for activated partial thromboplastin time (aPTT), prothrombin time (PT), and the international normalized ratio (INR) using data from the Central Laboratory of Konya City Hospital. The study retrospectively analyzed PT, aPTT, and INR results from patients aged 0-95 years who underwent preoperative evaluations for minor elective surgeries between August 2020 and March 2023. Patients with genetic or acquired bleeding disorders or who were on regular anticoagulant therapy (e.g., warfarin, LMWH, ASA) were excluded. PT and aPTT measurements were conducted using the Sysmex CS 5100 coagulation analyzer with an optical detection method. A total of 1,253 individuals (708 males and 545 females) were divided into 12 age groups. The results indicated an INR reference range of 0.93-1.29 for all patients. The PT reference ranges were determined as 10.70-14.50 seconds, while aPTT reference ranges varied by age. For instance, for patients aged 0-5 months, the lower and upper limits were 20.63 and 35.45 seconds, respectively; for patients aged six months and over, these limits were 19.7 and 29.6 seconds. Our study revealed differences with the reference ranges provided by manufacturers and emphasized the need for specific aPTT reference ranges for some pediatric age groups compared to adults.

Özet

Konya Şehir Hastanesi Merkezi Laboratuvar verilerinden elde edilen bilgilerle hastane popülasyonunda kullanılmak üzere parsiyel tromboplastin zamanı (aPTT), protrombin zamanı (PT) ve uluslararası normalize edilmiş oranın (INR) yaş ve cinsiyete özgü referans değerlerinin belirlenmesi amaçlanmıştır. Ağustos 2020-Mart 2023 tarihleri arasında Konya Şehir Hastanesine minör elektif cerrahi öncesi preoperatif değerlendirme kapsamında başvuran 0-95 yaş arasındaki hastaların PT, aPTT ve INR test sonuçları retrospektif olarak incelenmiştir. Çalışmaya genetik veya edinilmiş kanama bozukluğu olan, kanama bozukluğu tedavisi (varfarin, DMAH, ASA) için düzenli ilaç kullanan hastalar dahil edilmemiştir. PT ve aPTT ölçümleri, otomatik pıhtılaşma analiz cihazı olan Sysmex CS 5100’de optik algılama yöntemiyle gerçekleştirilmiştir. Toplam 1253 kişi (708 erkek ve 545 kadın) yaşlarına göre 12 gruba ayrılmıştır. Sonuçlar, INR alt sınır değerinin tüm hastalarda 0,93; üst sınır değerinin ise 1,29 olduğunu göstermiştir. PT alt sınır değeri tüm hastalar için 10,70 saniye, üst sınır değeri ise 14,50 saniye olarak belirlenmiştir. aPTT referans aralıkları yaş gruplarına göre değişiklik göstermiştir; örneğin, 0-5 ay grubunda alt sınır 20,63 ve üst sınır 35,45 saniye iken, 6 ay ve üzeri hastalarda alt sınır 19,7 ve üst sınır 29,6 saniye olarak bulunmuştur. Çalışmamız sonucunda, üreticiler tarafından sağlanan referans aralıkları ile farklılıklar olduğu ortaya konmuş ve yetişkinlere kıyasla bazı pediatrik yaş grupları için spesifik aPTT referans aralıklarının gerekliliği vurgulanmıştır.

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Cite This Article

Deniz, Ç. D., Tayiz, S., Tutar, M. S., Yıldırım, H. B., Yıldız, M., Erdem, S., Kozanhan, B., Sak, D. Y., Tonbaklar, P. (2025). Determination of Coagulation Tests Reference Ranges from Konya City Hospital Central Laboratory Data by Indirect Method and Investigation of Age-Dependent Changes. DÜSTAD Dünya Sağlık ve Tabiat Bilimleri Dergisi, Cilt: 8 Sayı: 1, 18–27. https://doi.org/10.56728/dustad.1616278

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