Journals / Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi / 2026 / Volume: 8 Issue: Special Issue Special Issue

THE EFFECT OF COVID-19 ON INFERTILITY

Covid-19'un İnfertiliteye Etkisi

Demet Çakır(GAZİOSMANPAŞA ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ)0000-0003-4794-516X
Hilal Özbek(TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ, EBELİK BÖLÜMÜ)0000-0001-6368-2633
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Publication Date
2023-12-16
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This study was written to determine the effect of COVID-19 on reproductive health

📌 3 Key Takeaways

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Objective & Hypothesis:Infertility is a common health problem affecting approximately 8-12% of the world's population.
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Key Findings & Data:These rates vary greatly in various regions of the world, and it is known that direct and indirect factors negatively affect fertility.
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Conclusion & Impact:This study was written to determine the effect of COVID-19 on reproductive health
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:COVID-19 · infertility · fertility

Abstract

Infertility is a common health problem affecting approximately 8-12% of the world's population. These rates vary greatly in various regions of the world, and it is known that direct and indirect factors negatively affect fertility. Exposure to toxic substances, malnutrition, psychological stress and viral infections can be counted as factors known to affect reproductive health. Coronavirus disease-19 (COVID-19) is a global health problem. Epidemiological reports showing the effects of this disease on reproductive health have reported various adverse effects. In the literature, bilateral orciepididymitis was detected in a 37-year-old man diagnosed with COVID-19. In a pediatric patient who was diagnosed with COVID-19 infection, inflammation associated with orciepididymitis was detected and deterioration in sperm quality was found in the patients. It is also suggested that the increased immune response in testicular cells may adversely affect the spermatogenesis process. When women of reproductive age are infected with COVID-19, a decrease in menstrual cycle bleeding volume and a prolongation of the cycle duration have been detected. It is thought that these results may be detrimental to fertility in the future. It has been reported in the past that the incidence of spontaneous abortion and preterm birth has increased among pregnant women infected with coronavirus. In systematic review and meta-analysis studies, it has also been documented that the risk of maternal death during pregnancy is increased in COVID-19 patients and vertical transmission of the virus particle from the infected mother to the newborn. For this reason, it is thought that COVID-19 infection may have negative effects on reproductive health of women and men. Awareness of midwives working in infertility clinics on this issue will be effective in using their counseling and care roles. This study was written to determine the effect of COVID-19 on reproductive health

Özet

İnfertilite, dünya nüfusunun yaklaşık %8-12'sini etkileyen yaygın bir sağlık sorunudur. Bu oranları dünyanın çeşitli bölgelerinde büyük farklılıklar göstermekte, doğrudan ve dolaylı faktörlerin doğurganlığı olumsuz etkilediği bilinmektedir. Toksik maddelere maruz kalma, yetersiz beslenme, psikolojik stres ve viral enfeksiyonlar üreme sağlığını etkilediği bilinen faktörlerden olarak sayılabilmektedir. Coronavirus hastalığı-19 (COVID-19) küresel bir sağlık sorunudur. Bu hastalığın üreme sağlığı üzerindeki etkilerini gösteren epidemiyolojik raporlar çeşitli olumsuz etkileri olduğunu bildirilmiştir. Literatürde, COVID-19 tanısı almış 37 yaşındaki bir erkekte bilateral orsiepididimit oluşumu tespit edilmiştir. COVID-19 enfeksiyonu tanısı almış olan bir pediatrik hastada ise orsiepididimit ile ilişkili inflamasyon belirlenmiş ve hastalarda sperm kalitesinde bozulma saptanmıştır. Ayrıca testis hücrelerinde artan bağışıklık tepkisinin spermatogenez sürecini olumsuz etkileyebileceği öne sürülmektedir. Üreme çağındaki kadınlarda da COVID-19 ile enfekte olduklarında menstrual siklus kanama hacminde azalma ve siklus süresinde uzama tespit edilmiştir. Bu sonuçların gelecekte doğurganlık için zararlı olabileceği düşünülmektedir. Geçmişte koronavirüs bulaşmış gebeler arasında spontan düşük ve erken doğum insidanslarının arttığı bildirilmiştir. Sistematik inceleme ve meta-analiz çalışmalarında, COVID-19 hastalarında gebelik sırasında anne ölümü riskinin arttığı ve virüs partikülünün enfekte anneden yenidoğana dikey geçişi yaptığı da belgelenmiştir. Bu nedenle COVID-19 enfeksiyonunun kadın ve erkek üreme sağlığı üzerinde olumsuz etkilerinin olabileceği düşünülmektedir. İnfertilite kliniklerinde çalışan ebelerin bu konuda bilinçlenmesi, danışmalık ve bakım rollerini kullanmada etkili olacaktır. Bu çalışma COVID-19’un üreme sağlığı üzerine etkisini belirlemek amacıyla yazılmıştır.

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Cite This Article

Çakır, D., Özbek, H. (2023). THE EFFECT OF COVID-19 ON INFERTILITY. Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, Volume: 8 Issue: Special Issue Special Issue. https://doi.org/10.51754/cusbed.1312431

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References (47)

  1. Aharon, D., Canon, C.M., Hanley, W.J., Lee J.A., Lederman M.A., Stein D.E., & et al. (2021) Mrna COVID-19 vaccines do not compromise implantation of euploid embryos. Fertil Steril, 116. doi: 10.1016/j.fertnstert.2021.07.215
  2. Ali, R. I., & Ibrahim, M. A. (2018). Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin. Egyptian Journal of Forensic Sciences, 8: 1-13. https://doi.org/10.1186/s41935-018-0099-x
  3. Althof, S.E., & Needle, R.B. (2011). Psychological factors associated with male sexual dysfunction: screening and treatment for the urologist. Urol Clin North Am, 38:141–6. https://doi.org/10.1016/j.ucl.2011.02.003
  4. Asghar, N., Mumtaz, H., Syed, A.A., Eqbal, F., Maharjan, R., Bamboria, A., & et al. (2022). Safety, efficacy, and immunogenicity of COVID-19 vaccines; a systematic review. Immunological Medicine. 1-13 doi: 10.1080/25785826.2022.2068331
  5. Cacioppo, J.T., Berntson, G.G., Malarkey, W.B., Kiecolt-Glaser, J.K., Sheridan, J.F., Poehlmann, K.M., & et al. (1998). Autonomic, neuroendocrine, and immune responses to psychological stress: the reactivity hypothesis. Ann N Y Acad Sci, 840:664-673. https://doi.org/10.1111/j.1749-6632.1998.tb09605.x
  6. Carp-Veliscu, A., Mehedintu, C., Frincu, F., Bratila, E., Rasu, S., Iordache, I., Bordea, A., & Braga, M. (2022). The Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature. Int J Environ Res Public Health. 16:984. doi: 10.3390/ijerph19020984.
  7. Carto, C., Nackeeran, S., & Ramasamy, R. (2022). COVID-19 vaccination is associated with a decreased risk of orchitis and/or epididymitis in men. Andrologia. 54. doi: 10.1111/and.14281
  8. Chen, F., Zhu, S., Dai, Z., Hao, L., Luan, C., Guo, Q., & et al. (2021). Effects of COVID-19 and mRNA vaccines on human fertility. Hum Reprod. 37:5-13. doi: 10.1093/humrep/deab238.
  9. Cochrane Gynaecology and Fertility (2023). COVID-19-Fertility and Pregnancy, https://cgf.cochrane.org/news/covid-19-coronavirus-disease-fertility-and-pregnancy erişim tarihi:27.03.2023
  10. Comirnaty and Pfizer-BioNTech COVID-19 Vaccine FDA. (2021, March 2). https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/comirnaty-and-pfizer-biontech-covid-19-vaccine.
  11. Dong, L., Tian, J., He, S., Zhu, C., Wang, J., Liu, C., & et al. (2020). Possible verticaltransmission of SARS-CoV-2 from an infected mother to her newborn. JAMA. 323:1846-1848. doi:10.1001/jama.2020.4621
  12. Drapkina Yu, D., Yu, S., Dolgushina, D.N.V., Shatylko, T.S.T.V., Nikolaeva, M.N.M.A., Menzhinskaya, I.M.I.V., Ivanets, I.T.Yu., Krechetova, L.K.L.V., Gamidov, S.G.S.I., Bairamova, B.G.R., & Sukhikh, S.G.T. (2021). Gam-COVID-Vac (Sputnik V) vaccine has no adverse effect on spermatogenesis in men. Akusherstvo i Ginekologiia. 7:88-94. https://doi.org/10.18565/aig.202L7.88-94
  13. Elagin, V.V., Adamyan, L.V., Vechorko, V.I., Doroshenko, D.A., Dashko, A.A., Filippov, O.S., & et al. (2021). COVID-19 vaccine and male reproductive health (preliminary data) Problemy Reproduktsii. 27:17. doi: 10.17116/repro20212704117
  14. Gagliardi, L., Bertacca, C., Centenari, C., Merusi, I., Parolo, E., Ragazzo, V., & et al. (2020). Orchiepididymitis in a boy with COVID-19. Pediatr Infect Dis J. 39:e200-2. doi: 10.1097/INF.0000000000002769
  15. Garolla, A., Pizzol, D., Bertoldo, A., Menegazzo, M., Barzon, L., & Foresta, C. (2013). Sperm viral infection and male infertility: focus on HBV, HCV, HIV, HPV, HSV, HCMV, and AAV. Journal of reproductive immunology, 100:20-29. https://doi.org/10.1016/j.jri.2013.03.004
  16. Goad, J., Rudolph, J., & Rajkovic, A. (2020). Female reproductive tract has low concentration of SARS-CoV2 receptors. bioRxiv. Plos One. 15:e0243959. doi: 10.1101/2020.06.20.163097
  17. Gollenberg, A.L., Liu, F., Brazil, C., Drobnis, E.Z., Guzick, D., Overstreet, J.W., & et al. (2010). Semen quality in fertile men in relation to psychosocial stress. Fertil Steril. 93:1104–1111. https://doi.org/10.1016/j.fertnstert.2008.12.018
  18. Greenland, J.R., Michelow, M.D., Wang, L., & London, M.J. (2020). COVID-19 infection: implications for perioperative and critical care physicians. Anesthesiology. 132:134-1361. https://doi.org/10.1097/ALN.0000000000003303
  19. Holtmann, N., Edimiris, P., Andree, M., Doehmen, C., Baston-Buest, D., Adams, O., & et al. (2020). Assessment of SARS-CoV-2 in human semen-a cohort study. Fertil Steril. 114:233-238. https://doi.org/10.1016/j.fertnstert.2020.05.028
  20. Homa, S.T., Vassiliou, A.M., Stone, J., Killeen, A.P., Dawkins, A., Xie, J., Gould, F., & Ramsay, J.W.A. (2019). A comparison between two assays for measuring seminal oxidative stress and their relationship with sperm DNA fragmentation and semen parameters. Genes. 10:236. doi: 10.3390/genes10030236
  21. Honorato-Sampaio, K., Pereira, V.M., Santos, R.A., & Reis, A.M. (2012). Evidence that angiotensin-(1-7) is an intermediate of gonadotrophin-induced oocyte maturation in the rat preovulatory follicle. Exp Physiol. 97:642-50. doi: 10.1113/expphysiol.2011.061960
  22. Jurewicz, J., Hanke, W., Sobala, W., Merecz, D., & Radwan, M. (2010). Wplyw stresu zawodowego na jakosc nasıenıa/the effect of stress on the semen qualıty. Medycyna Pracy. 61:607-613.
  23. Kotitschke, A., Sadie-Van Gijsen, H., Avenant, C., Fernandes, S., & Hapgood, J.P. (2009). Genomic and nongenomic cross talk between the gonadotropin-releasing hormone receptor and glucocorticoid receptor signaling pathways. Mol Endocrinol. 23:1726-1745. https://doi.org/10.1210/me.2008-0462
  24. Li, H., Xiao, X., Zhang, J., Zafar, M.I., Wu, C., Long, Y., & et al. (2020). Impaired spermatogenesis in COVID-19 patients. EClinicalMedicine. 28:100604. https://doi.org/10.1016/j.eclinm.2020.100604
  25. Li, K., Chen, G., Hou, H., Liao, Q., Chen, J., Bai, H., & et al. (2021). Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. Reprod Biomed Online. 42:260-267. https://doi.org/10.1016/j.rbmo.2020.09.020
  26. Mali, A.S., Magdum, M., & Novotny, J. (2021). COVID-19 impact on reproduction and fertility. JBRA Assist Reprod. 25:310-313. doi: 10.5935/1518-0557.20200103.
  27. Matar, R., Alrahmani, L., Monzer, N., Debiane, L.G., Berbari, E., Fares, J., & et al. (2021). Clinical presentation and outcomes of pregnant women with coronavirus disease 2019: a systematic review and meta-analysis. Clin Infect Dis. 72:521-33. https://doi.org/10.1093/cid/ciaa828
  28. Menezo, Y.J., Silvestris, E., Dale, B., & Elder, K. (2016). Oxidative stress and alterations in DNA methylation: two sides of the same coin in reproduction. Reprod Biomed Online. 33:668-683. doi: 10.1016/j.rbmo.2016.09.006
  29. Nassau, D.E., Best, J.C., Kresch, E., Gonzalez, D.C., Khodamoradi, K., Ramasamy, R. (2022). Impact of the SARS-CoV-2 virus on male reproductive health. BJU Int. Feb;129:143-150. doi: 10.1111/bju.15573.
  30. Orvieto, R., Noach-Hirsh, M., Segev-Zahav, A., Haas, J., Nahum, R., & Aizer, A. (2021). Does mRNA SARS-CoV-2 vaccine influence patients’ performance during IVF-ET cycle? Reproductive Biology and Endocrinology. 19:69. doi: 10.1186/s12958-021-00757-6
  31. Qiu, X., Zhang, L., Tong, Y., Qu, Y., Wang, H., & Mu, D. (2018). Interleukin-6 for early diagnosis of neonatal sepsis with premature rupture of the membranes: a metaanalysis. Medicine (Baltimore). 97:e13146. doi: 10.1097/MD.0000000000013146
  32. Pan, P.P., Zhan, Q.T., Le, F., Zheng, Y.M., & Jin, F. (2013). Angiotensin-converting enzymes play a dominant role in fertility. Int J Mol Sci. 14:21071-86. doi: 10.3390/ ijms141021071
  33. Rajak, P., Roy, S., Dutta, M., Podder, S., Sarkar, S., Ganguly, A.,. & Khatun, S. (2021). Understanding the cross-talk between mediators of infertility and COVID-19. Reproductive biology, 21:100559. https://doi.org/10.1016/j.repbio.2021.100559
  34. Reschini, M., Pagliardini, L., Boeri, L., Piazzini, F., Bandini, V., Fornelli G., & et al. (2022). COVID-19 vaccination does not affect reproductive health parameters in men. Front Public Health. 10. doi: 10.3389/fpubh.2022.839967
  35. Romer, D., & Jamieson, K.H. (2020). Conspiracy theories as barriers to controlling the spread of COVID-19 in the U.S. Soc Sci Med. 263 doi: 10.1016/j.socscimed.2020.113356
  36. Rozhivanov, R.V., & Mokrysheva, N.G. (2021). Ejaculate quality and testosterone levels in men vaccinated with Gam-Covid-Vac (Sputnik-V). Problemy Reproduktsii. 27:22. doi: 10.17116/repro20212704122
  37. Ssentongo, P., Ssentongo, A.E., Voleti, N., Groff, D., Sun, A., Ba, D.M., & et al. (2022). SARS-CoV-2 vaccine effectiveness against infection, symptomatic and severe COVID-19: a systematic review and meta-analysis. BMC Infect Dis. 22:439. doi: 10.1186/s12879-022-07418-y.
  38. Tanacan, A., Yazihan, N., Erol, S.A., Anuk, A.T., Yucel Yetiskin, F.D., Biriken, D., & et al. (2021). The impact of COVID-19 infection on the cytokine profile of pregnant women: a prospective case-control study. Cytokine. 140:155431. https://doi.org/10.1016/j.cyto.2021.155431
  39. Tokgoz, V.Y., Kaya, Y., & Tekin, A.B. (2020). The level of anxiety in infertile women whose ART cycles are postponed due to the COVID-19 outbreak. J Psychosom Obstet Gynaecol. 1-8. https://doi.org/10.1080/0167482X.2020.1806819.
  40. Vander Borght, M., & Wyns, C. (2018). Fertility and infertility: Definition and epidemiology. Clinical Biochemistry, 62:2-10. doi:10.1016/j.clinbiochem.2018.03.012
  41. Zaçe, D., La Gatta, E., Petrella, L., & Di Pietro, M.L. (2022). The impact of COVID-19 vaccines on fertility-A systematic review and meta-analysis. Vaccine. 40:6023-6034. https://doi.org/10.1016/j.vaccine.2022.09.019
  42. Wesselink, A.K., Hatch, E.E., Rothman, K.J., Wang, T.R., Willis, M.D., Yland, J., & et al. (2022). A Prospective Cohort Study of COVID-19 Vaccination, SARS-CoV-2 Infection, and Fertility. Am J Epidemiol. 191:1383-1395. https://doi.org/10.1093/aje/kwac011
  43. Wong, S.F., Chow, K.M., Leung, T.N., Ng, W.F., Ng, T.K., Shek, C.C., & et al. (2004). Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstet Gynecol. 191:292–297. https://doi.org/10.1016/j.ajog.2003.11.019
  44. Wodarg, W.S.D. (2020). Petition/motion for administrative/regulatory action regarding confirmation of efficacy end points and use of data in connection with the following clinical trial (s): phase III-eudract number: 2020-002641-2. corona-ausschuss.de.
  45. Xiang, Y.T., Yang, Y., Li, W., Zhang, L., Zhang, Q., Cheung, T., & et al. (2020). Timely mental health care for the 2019 novel coronavirus outbreak is urgently needed. Lancet Psychiatry. 7:228-229. doi:https://doi.org/10.1016/S2215-0366(20)30046-8.
  46. Xiao, Y.C., Huang, Y.D., Hardy, D.O., Li, X.K., & Ge, R.S. (2010) Glucocorticoid suppresses steroidogenesis in rat progenitor Leydig cells. J Androl. 31:365-71. https://doi.org/10.2164/jandrol.109.009019
  47. Rajak, P., Roy, S., Dutta, M., Podder, S., Sarkar, S., Ganguly, A.,. & Khatun, S. (2021). Understanding the cross-talk between mediators of infertility and COVID-19. Reproductive biology, 21:100559. https://doi.org/10.1016/j.repbio.2021.100559