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Journals / Archives of Clinical and Experimental Medicine / 2018 / Cilt: 3 - Sayı: 3

Role of calcium–albumin ratio in severity of coronary artery disease assessed by angiographic SYNTAX score

Anjiyografik SYNTAX skoru ile değerlendirilen koroner arter hastalığı ciddiyetinde kalsiyum-albumin oranının rolü

YAKUP ALSANCAK
Serkan SİVRİ
Serdal BAŞTUĞ
Engin BOZKURT
Pages
174–178
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further large-scale studies are warranted to confirm our findings.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Numerous studies have reported a relationship between serum calcium or albumin levels and acute coronary syndromes and coronary artery disease.
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Key Findings & Data:Methods: This prospective study included patients with non-ST elevation myocardial infarction (NSTEMI, n=120) and a control group (n=109).
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Conclusion & Impact:Further large-scale studies are warranted to confirm our findings.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Non-ST elevasyonlu akut miyokard infarktüsü · SYNTAX skoru · kalsiyum-albumin oranı

Abstract

Aim: Numerous studies have reported a relationship between serum calcium or albumin levels and acute coronary syndromes and coronary artery disease. The present study investigated the relation between serum albumin, calcium or albumin-corrected calcium levels or calcium/albumin ratio (CAR) and extensiveness and severity of atherosclerosis. Methods: This prospective study included patients with non-ST elevation myocardial infarction (NSTEMI, n=120) and a control group (n=109). We used the SYNTAX score to evaluate the association between CAR and severity and extent of coronary artery disease. Results: There were higher, but statistically nonsignificant, levels of calcium in patients with NSTEMI (p=0.058). However, serum albumin-corrected calcium levels were significantly higher in NSTEMI group (p=0.001). Yet, albumin levels did not differ between the groups (p=0.093). CAR and corrected calcium–albumin ratio (cCAR) were significantly higher in NSTEMI group (p=0.001). A positive correlation existed between CAR (r=0.235, p=0.010), cCAR (r=0.259, p=0.004), and SYNTAX score, whereas albumin and SYNTAX score (r=−0.259, p=0.004) showed a negative correlation. Conclusion: Calcium/albumin ratio has been found to be associated with an increased coronary atherosclerotic burden as calculated by SYNTAX score. Further large-scale studies are warranted to confirm our findings.

Özet

Amaç: Serum kalsiyum ve albumin seviyeleri ile akut koroner sendromlar ve koroner arter hastalığı arasındaki ilişki birçok çalışmada gösterilmiştir. Sunulan çalışmada, serum albumin, kalsiyum, albumin-düzeltilmiş kalsiyum seviyeleri ve kalsiyum/albumin oranı (KAO) ile aterosklerozun yaygınlık ve ciddiyetinin ilişkisi araştırılmıştır. Yöntemler: Bu prospektif çalışmaya non-ST elevasyonlu miyokard infarktüsü olan hastalar (NSTEMI, n=120) ve kontrol grubu (n=109) dahil edildi. KAO ile koroner arter hastalığı yaygınlık ve ciddiyetinin ilişkisini değerlendirmek için SYNTAX skoru kullanıldı. Bulgular: NSTEMI hastalarında istatistiksel anlamlı olmadan daha yüksek kalsiyum seviyeleri vardı (p=0.058). Buna rağmen serum albumin-düzeltilmiş kalsiyum seviyeleri istatistiksel anlamlı olarak NSTEMI grubunda daha yüksekti (p=0.001). Albumin seviyeleri ise gruplar arasında farklılık göstermedi (p=0.093). KAO ve düzeltilmiş kalsiyum/albumin oranı (dKAO), NSTEMI grubunda anlamlı olarak daha yüksekti (p=0.001). KAO (r=0.235, p=0.010) ve dKAO (r=0.259, p=0.004) ile SYNTAX skoru arasında pozitif korelasyon mevcut iken, albumin ile SYNTAX skoru (r=−0.259, p=0.004) arasında negatif korelasyon görüldü. Sonuç: Kalsiyum/albumin oranı, SYNTAX skoru ile hesaplanan artmış koroner aterosklerotik yük ile ilişkili bulunmuştur. Bulgularımızı doğrulamak için daha geniş çaplı çalışmalar gereklidir.

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Cite This Article

ALSANCAK, Y., SİVRİ, S., BAŞTUĞ, S., BOZKURT, E. (2018). Role of calcium–albumin ratio in severity of coronary artery disease assessed by angiographic SYNTAX score. Archives of Clinical and Experimental Medicine, Cilt: 3 - Sayı: 3, 174–178. https://ajindex.com/articles/147131

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