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Journals / Anestezi Dergisi / 2018 / Cilt: 26 - Sayı: 3

TÜRK‹YE'DE PED‹YATR‹K HASTALARDA PSÖDOKOL‹NESTERAZ EKS‹KL‹⁄‹ VE KATKIDA BULUNAN FAKTÖRLER‹N ‹NS‹DANSI

THE INCIDENCE OF PSEUDOCHOLINESTERASE DEFICIENCY AND CONTRIBUTING FACTORS IN PEDIATRIC PATIENTS IN TURKEY

Sengül ÖZMERT
Feyza SEVER
Sevil TOKAT
Sibel SAYDAM
Mine AKIN
Gülşen KESKİN
Devrim Tanıl KURT
Murat KIZILGÜN
Arif Osman TOKAT
Pages
159–163
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Çocuk hasta grubunda preoperatif dönemde, özellikle karaci¤er ve/veya böbrek fonksiyonlar›nda artm›fl de¤erler varl›¤›nda PKE eksikli¤inin görülme ihtimali göz önünde bulundurulmal›d›r.

📌 3 Key Takeaways

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Objective & Hypothesis:Amaç: Genel anestezi uygulamalar›nda gözlenen olas› komplikasyonlar aç›s›ndan oldukça önemli olan psödokolinesteraz (PKE) eksikli¤i s›kl›¤›n› ortaya koymak amaçlanm›flt›r.
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Key Findings & Data:Yöntem: Hastalar›n kay›tlar› (yafl, cinsiyet, serum PKE etki düzeyleri, karaci¤er ve böbrek fonksiyonlar›) bilgisayar ortam›nda yap›ld› ve veriler üzerinde çal›fl›ld›.
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Conclusion & Impact:Çocuk hasta grubunda preoperatif dönemde, özellikle karaci¤er ve/veya böbrek fonksiyonlar›nda artm›fl de¤erler varl›¤›nda PKE eksikli¤inin görülme ihtimali göz önünde bulundurulmal›d›r.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Amaç: Genel anestezi uygulamalar›nda gözlenen olas› komplikasyonlar aç›s›ndan oldukça önemli olan psödokolinesteraz (PKE) eksikli¤i s›kl›¤›n› ortaya koymak amaçlanm›flt›r. Yöntem: Hastalar›n kay›tlar› (yafl, cinsiyet, serum PKE etki düzeyleri, karaci¤er ve böbrek fonksiyonlar›) bilgisayar ortam›nda yap›ld› ve veriler üzerinde çal›fl›ld›. Bulgular: Hastalar›n %5.5'inde (n = 15.309) PKE düzeyi normal de¤erlerin alt›ndayd›. PKE eksikli¤i yüzdesi, yüksek alanin amino transferaz, aspartat amino transferaz, üre ve kreatinin düzeyleri olan hastalarda yüksek bulundu (p<0.001). ALT, AST, üre ve kreatinin düzeyi bir bütün olarak yüksek olan hastalar, PKE eksikli¤i yüzdesi % 50 idi (p<0.001). Sonuç: PKE eksikli¤i yayg›n bir durumdur. Çocuk hasta grubunda preoperatif dönemde, özellikle karaci¤er ve/veya böbrek fonksiyonlar›nda artm›fl de¤erler varl›¤›nda PKE eksikli¤inin görülme ihtimali göz önünde bulundurulmal›d›r.

Özet

Objective: It is aimed to reveal the frequency of pseudocholinesterase (PCE) deficiency, which is highly important for the possible complications observed during the general anaesthesia applications. Method: The records of patients (age, sex, serum PCE effect levels, liver and kidney functions) were computerized and studied on the data. Results: PCE level in 5.5% of the patients (n=15.309) were under the normal values. The PCE deficiency percentage was high with high alanine amino transferase, aspartate amino transferase, ure and creatinin levels (p<0.001). The patients whose ALT, AST, ure and creatinin level were high as a whole, PCE deficiency percentage was 50% (p<0.001). Conclusion: PCE deficiency is a widespread situation. It is probable to think about the occurrence of the PCE deficiency in case of the increased values especially in the liver and/or kidney functions during the preoperative run in the child patient group.

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Cite This Article

ÖZMERT, S., SEVER, F., TOKAT, S., SAYDAM, S., AKIN, M., KESKİN, G., KURT, D. T., KIZILGÜN, M., TOKAT, A. O. (2018). TÜRK‹YE'DE PED‹YATR‹K HASTALARDA PSÖDOKOL‹NESTERAZ EKS‹KL‹⁄‹ VE KATKIDA BULUNAN FAKTÖRLER‹N ‹NS‹DANSI. Anestezi Dergisi, Cilt: 26 - Sayı: 3, 159–163. https://ajindex.com/articles/147100

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