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Journals / ALKÜ Fen Bilimleri Dergisi / 2026 / Cilt: 6 Sayı: 1

Synthesis of Carbothioamide Substituted Benzimidazole Compounds and Investigation of Biological Activities

Karbotiyoamidin Sübstitüye Benzimidazol Bileşiklerinin Sentezi ve Biyolojik Aktivitelerinin İncelenmesi

Taner İlker Gümrükçüoğlu(GÜMÜŞHANE ÜNİVERSİTESİ, KÜRTÜN MESLEK YÜKSEKOKULU, MÜLKİYET KORUMA VE GÜVENLİK BÖLÜMÜ, SİVİL SAVUNMA VE İTFAİYECİLİK PROGRAMI)0000-0002-9453-602X
Hakan Akgün(GİRESUN ÜNİVERSİTESİ, FEN BİLİMLERİ ENSTİTÜSÜ, KİMYA (DR))0000-0003-3586-4194
Bahar Bilgin Sökmen(GİRESUN ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ, KİMYA BÖLÜMÜ, BİYOKİMYA ANABİLİM DALI)0000-0003-3904-8178
Hakan Bektaş(GİRESUN ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ, KİMYA BÖLÜMÜ)0000-0002-5202-7323
Pages
1–15
Publication Date
2024-04-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The compound with the highest antioxidant activity was determined as compound number 5, and the compound with the lowest antioxidant activity was determined as compound number 4.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Heterocyclic compounds containing nitrogen along with an oxygen atom in their structure are a major class of medicinal chemistry compounds due to their diverse biological applications.
📊
Key Findings & Data:In this study, the antiurease and antioxidant activities of the synthesized benzimidazole derivatives (1-5) were investigated by spectrophotometric methods.
💡
Conclusion & Impact:The compound with the highest antioxidant activity was determined as compound number 5, and the compound with the lowest antioxidant activity was determined as compound number 4.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:ABTS ve DPPH aktivitesi · Antiüreaz aktivite · Antioksidan aktivite

Abstract

Heterocyclic compounds containing nitrogen along with an oxygen atom in their structure are a major class of medicinal chemistry compounds due to their diverse biological applications. Benzimidazoles is also a heterocyclic aromatic organic compound in this group, carrying two different nitrogen (N) atoms in the ring structure. In this study, the antiurease and antioxidant activities of the synthesized benzimidazole derivatives (1-5) were investigated by spectrophotometric methods. Evidence of antioxidant activity clearly shows us that there is a defense mechanism against diseases that may occur in the body. All synthesized benzimidazole compounds showed antiurease and antioxidant activity. The most potent compound showing urease inhibition activity is number 2, and the least active compound is compound number 4. All compounds showed higher activity than thiourea. The compound with the highest antioxidant activity was determined as compound number 5, and the compound with the lowest antioxidant activity was determined as compound number 4.

Özet

Yapılarında bir oksijen atomu ile birlikte nitrojen içeren heterosiklik bileşikler, çeşitli biyolojik uygulamaları nedeniyle önemli bir tıbbi kimya bileşikleri sınıfıdır. Benzimidazoller de bu grupta yer alıp, halka yapısında farklı yapıda iki azot (N) atomu taşıyan heterosiklik bir aromatik organik bileşiktir. Yapılan bu çalışmada, sentezlenen benzimidazol türevlerinin (1-5) antiüreaz ve antioksidan aktiviteleri spektrofotometrik metotlarla incelendi. Antioksidan aktivitesinin kanıtı bizlere vücutta oluşabilecek hastalıklara karşı savunma mekanizmasının var olduğunu açıkça göstermektedir. Sentezlenen tüm benzimidazol bileşikleri antiüreaz ve antioksidan aktivite gösterdi. Üreaz inhibisyon aktivitesi gösteren en güçlü bileşik 2 numaralı, en az aktif bileşik ise 4 numaralı bileşiktir. Tüm bileşikler tiyoüreden daha yüksek aktivite gösterdi. En yüksek antioksidan aktivitesine sahip bileşik 5 numaralı bileşik, en düşük antioksidan aktivitesine sahip bileşik ise 4 numaralı bileşikler olarak belirlendi.

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Cite This Article

Gümrükçüoğlu, T. İ., Akgün, H., Sökmen, B. B., Bektaş, H. (2024). Synthesis of Carbothioamide Substituted Benzimidazole Compounds and Investigation of Biological Activities. ALKÜ Fen Bilimleri Dergisi, Cilt: 6 Sayı: 1, 1–15. https://doi.org/10.46740/alku.1340210

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