SavedAdd your journal

Journals / Ahi Evran Tıp Dergisi / 2024 / Volume: 8 Issue: 3

Osteopenia in Newborns with Spinal Canal Defects

Spinal Kanal Defekti Olan Yenidoğanlarda Osteopeni

Sevdet Balık(UNIVERSITY OF HEALTH SCIENCES, DİYARBAKIR GAZİ YAŞARGİL HEALTH RESEARCH CENTER)0009-0000-0781-2990
Nilufer Okur(UNIVERSITY OF HEALTH SCIENCES, DİYARBAKIR GAZİ YAŞARGİL HEALTH RESEARCH CENTER)0000-0002-0027-0532
Leyla Şero(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, DİYARBAKIR GAZİ YAŞARGİL SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-5224-8583
Duygu Tunçel(UNIVERSITY OF HEALTH SCIENCES, DİYARBAKIR GAZİ YAŞARGİL HEALTH RESEARCH CENTER)0000-0002-8013-0619
Muhammet Asena(UNIVERSITY OF HEALTH SCIENCES, DİYARBAKIR GAZİ YAŞARGİL HEALTH RESEARCH CENTER)0000-0002-0033-8672
Pages
—
Publication Date
2024-12-17
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Close monitoring of bone quality and fracture development in these infants, along with medical treatment support when necessary, is recommended.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: Fracture development is one of the complications in patients with spina bifida, with an incidence ranging from 11% to 30%.
📊
Key Findings & Data:Materials and Methods: Cases who were hospitalized and operated on in our neonatal intensive care unit with the diagnosis of meningomyelocele (MMS) between 01 December 2020 and 31 January 2023 constituted the study group and were evaluated retrospectively.
💡
Conclusion & Impact:Close monitoring of bone quality and fracture development in these infants, along with medical treatment support when necessary, is recommended.
🔬Design:Research Article
📍Scope:2020 Verileri
⚙️Variables:fracture · meningomyelocele · newborn

Abstract

Purpose: Fracture development is one of the complications in patients with spina bifida, with an incidence ranging from 11% to 30%. This study aimed to investigate the frequency of fractures, osteopenia, and the factors associated with these conditions in neonates with spina bifida followed at our hospital. Materials and Methods: Cases who were hospitalized and operated on in our neonatal intensive care unit with the diagnosis of meningomyelocele (MMS) between 01 December 2020 and 31 January 2023 constituted the study group and were evaluated retrospectively. Perinatal findings (gender, mode of delivery, gestational week, birth weight), operation time, postoperative sepsis, additional accompanying anomalies, length of stay, serum free thyroxine (fT4) and thyroid stimulating hormone (TSH) levels were examined and recorded from the patient files. Results: A total of 89 neonates with MMS and encephalocele were evaluated. The median birth weight was 3000 g (range: 1800-4300 g), and the median gestational age was 38 weeks (range: 32-40 weeks). Hypocalcemia was present in 14 (15.7%) patients. One patient had a phosphorus level below 4 mg/dl. All infants had normal alkaline phosphatase levels. Fractures were observed in 5 (5.6%) patients, all of whom had paralysis in the lower extremities. Conclusion: There are many risk factors for fracture development in children with spina bifida, and fractures can often be overlooked due to low ambulation capacity and sensory deficits. Close monitoring of bone quality and fracture development in these infants, along with medical treatment support when necessary, is recommended.

Özet

Amaç: Kırık gelişimi; spina bifidalı hastalarda komplikasyonlardan biri olup, görülme oranı % 11-30 arasında değişmektedir. Bu çalışmada hastanemizde takipli spina bifidalı yenidoğanlarda; kırık sıklığı, osteopeni ve bu durumla ilişkili faktörlerin araştırılması amaçlandı. Araçlar ve Yöntem: Bu çalışmada 01 Aralık 2020 ile 31 Ocak 2023 tarihleri arasında yenidoğan yoğun bakım ünitemize meningomyelosel (MMS) tanısıyla yatırılarak opere edilen olgular çalışma grubunu oluşturmuş ve retrospektif olarak değerlendirilmiştir. Perinatal bulgular (cinsiyet, doğum şekli, gestasyonel hafta, doğum ağırlığı), operasyon zamanı, operasyon sonrası sepsis, eşlik eden ek anomaliler, yatış süresi, serum serbest tiroksin (fT4) ve tiroid stimüle edici hormon (TSH) düzeyleri hasta dosyalarından incelendi ve kaydedildi. Bulgular: Toplam 89 MMS ve ensefaloselli yenidoğan bebeğin verileri değerlendirildi. Doğum ağırlıkları median 3000 gr (min 1800-max 4300 gr) ve gestasyon haftası 38 (min 32- max 40)’tı. 14 (%15.7) hastada hipokalsemi vardı. Bir hastada fosfor düzeyi 4 mg/dl’ün altındaydı. Tüm bebeklerin alkalen fosfataz düzeyleri normaldi. 5 (%5.6) hastada ekstremitelerde kırık vardı. Kırık saptanan bebeklerin tamamında alt ekstremitede paralizi mevcuttu. Sonuç: Spina bifidalı çocuklarda kırık gelişimi için pek çok risk faktörü bulunmakta olup düşük ambulasyon kapasitesi ve duyu defisiti nedeniyle kırıklar kolaylıkla gözden kaçabilmektedir. Bu bebeklerin kemik kalitesi ve kırık gelişimi açısından yakın takibi ve gerektiğinde medikal tedavi desteği önerilmektedir.

🔖

Cite This Article

Balık, S., Okur, N., Şero, L., Tunçel, D., Asena, M. (2024). Osteopenia in Newborns with Spinal Canal Defects. Ahi Evran Tıp Dergisi, Volume: 8 Issue: 3. https://doi.org/10.46332/aemj.1394610

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Mitchell LE, Adzick NS, Melchionne JM, Pasquariello PS, Sutton LN, Whitehead AS. Spina bifida Lancet. 2004:364:1885-1895.
  2. Avagliano L, Massa V, George TM, Qureshy S, Bulfamante GP, Finnell RH. Overview on neural tube defects: From development to physical characteristics. Birth Defects Res. 2019;111:1455- 1467.
  3. Tunçbilek E. Türkiye’deki yüksek nöral tüp defekti sıklığı ve önlemek için yapılabilecekler. Çocuk Sağlığı ve Hastalıkları Derg. 2004;79-84.
  4. Marreiros H. Update on bone fragility in spina bifida. J Pediatr Rehabil Med. 2018;11:265-281.
  5. Dosa NP, Eckrich M, Katz DA, Turk M, Liptak GS. Incidence, prevalence, and characteristics of fractures in children, adolescents, and adults with spina bifida. J Spinal Cord Med. 2007;30 (Suppl 1):S5-9.
  6. Trinh A, Wong P, Brown J, S Hennel S, Ebeling PR, Fuller PJ, et al. Fractures in spina bifida from childhood to young adulthood. Osteoporos Int. 2017;28:399-406.
  7. Dawson- Hughes B, Heaney RP, Holick MF, Ips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int. 2005;16:713-716.
  8. Satar M, Arısoy AE, Çelik İH. Yenidoğan Enfeksiyonları Tanı ve Tedavi Rehberi 2023 Güncellemesi.
  9. Kriss VM, Kriss TC, Desai NS, Warf BC. Occult spinal dysraphism in the infant. Clin Pediatr. 1995; 34:650-654.
  10. Akbar M, Bresch B, Raiss P, et al. Fractures in myelomeningocele. J Orthop Traumatol.2010;11:175-182.
  11. Ausili E, Rigante D, Salvaggio E, et al. Determinants of bone mineral density, bone mineral content, and body composition in a cohort of healthy children: influence of sex, age, puberty, and physical activity. Rheumatol Int. 2012;32:2737-2743.
  12. Goulding A, Rockell JEP, Black RE, Grant AM, Jones IE, Williams SM. Children who avoid drinking cow’s milk are at increased risk for prepubertal bone fractures. J Am Diet Assoc. 2004;104(2):250-253.
  13. Martinelli V, Dell’Atti C, Ausili E, et al. Risk of fracture prevention in spina bifida patients: correlation between bone mineral density, vitamin D, and electrolyte values. Child’s Nervous System. 2015;31(8): 1361-1365.
  14. Işık DU, Ünal S, Demirel N, ve ark. Yenidoğanda Uzun Kemik Kırıklarının Retrospektif Değerlendirilmesi: Tek Merkez Deneyimi. Türkiye Çocuk Hastalıkları Dergisi. 2017;12(4):264-267.
  15. Matsubara S, Izumi A, Nagai T, Kıkkawa I, Suzuki M. Femur fracture during abdominal breech delivery. Arch Gynecol Obstet. 2008;278:195-197.
  16. Lock TR, Aronson DD. Fractures in patients who have myelomeningocele. J Bone Joint Surg Am. 1989; 71(8):1153-1157.