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Journals / Ahi Evran Tıp Dergisi / 2026 / Volume: 9 Issue: 2

The Evaluation of Hemodynamic and Endocrine Response and Nesfatin-1 in Patients Undergoing Inhalation and Total Intravenous Anesthesia

İnhalasyon ve Total İntravenöz Anestezi Uygulanan Hastalarda Hemodinamik, Endokrin Yanıt ve Nesfatin-1'in Değerlendirilmesi

Ahmet Aksu(FIRAT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-2689-528X
İsmail Demirel(FIRAT ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, ANESTEZİYOLOJİ ANABİLİM DALI)0000-0002-9183-8225
Pages
—
Publication Date
2025-08-08
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Different anesthesia techniques produced similar effects on hemodynamic and endocrine responses as well as nesfatin-1 levels in patients undergoing septoplasty.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: The aim of this study was to investigate the effects of different anesthesia techniques on the surgical stress response and nesfatin-1 levels.
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Key Findings & Data:Materials and Methods: This prospective, randomized, controlled study was conducted between March and June 2015.
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Conclusion & Impact:Conclusion: Different anesthesia techniques produced similar effects on hemodynamic and endocrine responses as well as nesfatin-1 levels in patients undergoing septoplasty.
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:surgical stress response · inhalation anesthesia · Nesfatin-1

Abstract

Purpose: The aim of this study was to investigate the effects of different anesthesia techniques on the surgical stress response and nesfatin-1 levels. Materials and Methods: This prospective, randomized, controlled study was conducted between March and June 2015. Ninety patients undergoing septoplasty were randomized into three groups: Desflurane + N2O (Group 1), Desflurane + Remifentanil (Group 2), and Propofol + Remifentanil (Group 3). Blood samples were collected immediately before induction, at the 30th minute in the postoperative recovery room, and at the 24th postoperative hour. Serum insulin, glucose, adrenaline, noradrenaline, cortisol, and nesfatin-1 levels were measured. Results: There were no significant differences between groups in glucose, adrenaline, noradrenaline, and nesfatin-1 levels at any time point (p > 0.05). However, insulin levels at the 24th postoperative hour were significantly higher in Group 1 compared to Group 3 (18.24 miu/ml vs. 5.52 miu/ml; p < 0.05). Cortisol levels measured at the 30th postoperative minute in Group 3 showed a significant increase compared to the other groups (10.82 μg/dl; p < 0.05). Conclusion: Different anesthesia techniques produced similar effects on hemodynamic and endocrine responses as well as nesfatin-1 levels in patients undergoing septoplasty.

Özet

Amaç: Çalışmanın amacı, farklı anestezi tekniklerinin cerrahi stres yanıtı ve nesfatin-1 düzeyleri üzerindeki etkilerini araştırmaktır. Araçlar ve Yöntem: Bu çalışma, Mart-Haziran 2015 tarihleri arasında prospektif, randomize ve kontrollü olarak gerçekleştirildi. Septoplasti operasyonu geçiren 90 hasta, Desfluran + N2O (Grup 1), Desfluran + Remifentanil (Grup 2) ve Propofol + Remifentanil (Grup 3) olmak üzere üç gruba randomize edildi. Kan örnekleri indüksiyondan hemen önce, postoperatif derlenme odasında 30. dakikada ve postoperatif 24. saatte alındı. Serum insülin, glukoz, adrenalin, noradrenalin, kortizol ve nesfatin-1 düzeyleri ölçüldü. Bulgular: Gruplar arasında glukoz, adrenalin, noradrenalin ve nesfatin-1 düzeyleri açısından herhangi bir zaman noktasında anlamlı fark gözlenmedi (p > 0,05). Ancak, postoperatif 24. saatte insülin düzeyleri Grup 1’de Grup 3’e kıyasla anlamlı derecede yüksekti (sırasıyla 18,24 miu/ml ve 5,52 miu/ml; p < 0,05). Postoperatif 30. dakikada Grup 3’te ölçülen kortizol seviyeleri diğer gruplara göre anlamlı bir artış gösterdi (10,82 μg/dl; p < 0,05). Sonuç: Septoplasti geçiren hastalarda farklı anestezi teknikleri, hemodinamik ve endokrin yanıtlar ile nesfatin-1 düzeyleri üzerinde benzer etkiler göstermiştir.

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Cite This Article

Aksu, A., Demirel, İ. (2025). The Evaluation of Hemodynamic and Endocrine Response and Nesfatin-1 in Patients Undergoing Inhalation and Total Intravenous Anesthesia. Ahi Evran Tıp Dergisi, Volume: 9 Issue: 2. https://doi.org/10.46332/aemj.1597215

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