The purpose of our study was to investigate the behavior of the acute phase reactants in Henoch Schonlein Purpura and to see if there was a relationship between the severity of the clinical manifestations and acute phase response We also wanted to determine if there was a correlation between the type of the manifestation and the level of acute phase measurements of eritrocyte sedimantation rate and C reactive protein levels at previously determined intervals from the 26 Henoch Schonlein Purpura patients referred to Pediatric policlinics of Cerrahpaşa Faculty of Medicine As a results we determined that both eritrocyte sedimantation rate and C reactive protein levels decreased gradually during the illness and there is no correlation between the severity of the manifestations and the level of acute phase response However eritrocyte sedimentation rate showed a significant increase during renal manifestations p lt;0 001 and myalgia p lt;0 05 ; whereas C reactive protein increased significantly during purpuric eruptions p lt;0 05 renal manifestations p lt;0 001 and myalgia p lt;0 05 Key words: Henoch Schonlein Purpura Clinical Findings Acute Phase Reactions
📌 3 Key Takeaways
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Objective & Hypothesis:The purpose of our study was to investigate the behavior of the acute phase reactants in Henoch Schonlein Purpura and to see if there was a relationship between the severity of the clinical manifestations and acute phase response We also wanted to determine if there was a correlation between the type of the manifestation and the level of acute phase measurements of eritrocyte sedimantation rate and C reactive protein levels at previously determined intervals from the 26 Henoch Schonlein Purpura patients referred to Pediatric policlinics of Cerrahpaşa Faculty of Medicine As a results we determined that both eritrocyte sedimantation rate and C reactive protein levels decreased gradually during the illness and there is no correlation between the severity of the manifestations and the level of acute phase response However eritrocyte sedimentation rate showed a significant increase during renal manifestations p lt;0 001 and myalgia p lt;0 05 ; whereas C reactive protein increased significantly during purpuric eruptions p lt;0 05 renal manifestations p lt;0 001 and myalgia p lt;0 05 Key words: Henoch Schonlein Purpura Clinical Findings Acute Phase Reactions
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Key Findings & Data:The purpose of our study was to investigate the behavior of the acute phase reactants in Henoch Schonlein Purpura and to see if there was a relationship between the severity of the clinical manifestations and acute phase response We also wanted to determine if there was a correlation between the type of the manifestation and the level of acute phase measurements of eritrocyte sedimantation rate and C reactive protein levels at previously determined intervals from the 26 Henoch Schonlein Purpura patients referred to Pediatric policlinics of Cerrahpaşa Faculty of Medicine As a results we determined that both eritrocyte sedimantation rate and C reactive protein levels decreased gradually during the illness and there is no correlation between the severity of the manifestations and the level of acute phase response However eritrocyte sedimentation rate showed a significant increase during renal manifestations p lt;0 001 and myalgia p lt;0 05 ; whereas C reactive protein increased significantly during purpuric eruptions p lt;0 05 renal manifestations p lt;0 001 and myalgia p lt;0 05 Key words: Henoch Schonlein Purpura Clinical Findings Acute Phase Reactions
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Conclusion & Impact:The purpose of our study was to investigate the behavior of the acute phase reactants in Henoch Schonlein Purpura and to see if there was a relationship between the severity of the clinical manifestations and acute phase response We also wanted to determine if there was a correlation between the type of the manifestation and the level of acute phase measurements of eritrocyte sedimantation rate and C reactive protein levels at previously determined intervals from the 26 Henoch Schonlein Purpura patients referred to Pediatric policlinics of Cerrahpaşa Faculty of Medicine As a results we determined that both eritrocyte sedimantation rate and C reactive protein levels decreased gradually during the illness and there is no correlation between the severity of the manifestations and the level of acute phase response However eritrocyte sedimentation rate showed a significant increase during renal manifestations p lt;0 001 and myalgia p lt;0 05 ; whereas C reactive protein increased significantly during purpuric eruptions p lt;0 05 renal manifestations p lt;0 001 and myalgia p lt;0 05 Key words: Henoch Schonlein Purpura Clinical Findings Acute Phase Reactions
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
The purpose of our study was to investigate the behavior of the acute phase reactants in Henoch Schonlein Purpura and to see if there was a relationship between the severity of the clinical manifestations and acute phase response We also wanted to determine if there was a correlation between the type of the manifestation and the level of acute phase measurements of eritrocyte sedimantation rate and C reactive protein levels at previously determined intervals from the 26 Henoch Schonlein Purpura patients referred to Pediatric policlinics of Cerrahpaşa Faculty of Medicine As a results we determined that both eritrocyte sedimantation rate and C reactive protein levels decreased gradually during the illness and there is no correlation between the severity of the manifestations and the level of acute phase response However eritrocyte sedimentation rate showed a significant increase during renal manifestations p lt;0 001 and myalgia p lt;0 05 ; whereas C reactive protein increased significantly during purpuric eruptions p lt;0 05 renal manifestations p lt;0 001 and myalgia p lt;0 05 Key words: Henoch Schonlein Purpura Clinical Findings Acute Phase Reactions
Özet
Cerrahpaşa Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı polikliniğine başvurarak Henoch Schönlein Purpurası tanısı alan 26 hastada belli aralıklarla klinik değerlendirme ve eritrosit sedimentasyon hızı ve C reaktif protein ölçümleri yapıldı Bu çalışmanın amacı Henoch Schönlein purpurasında akut faz reaktanlarının hastalığın süresi içinde nasıl bir değişim gösterdiğini ve kliniğin ağırlığı ile akut faz yanıtı arasında ilişki olup olmadığını ve varsa hangi klinik bulguyla ilişkili olduğunu araştırmaktı Çalışma sonunda hem eritrosit sedimantasyon hızı hem de C reaktif protein düzeylerinin hastalığın seyri sırasında giderek düştüğünü klinik tablonun ağırlığı ile eritrosit sedimantasyon hızı ve C reaktif protein düzeyleri arasında anlamlı bir ilişki bulunmadığını eritrosit sedimantasyon hızının en çok böbrek tutulumu p lt;0 001 ve miyalji p lt;0 01 varlığında C reaktif proteinin ise deri döküntüsü p lt;0 05 böbrek tutulumu p lt;0 001 ve miyalji p lt;0 05 sırasında anlamlı artış gösterdiğini saptadık Anahtar kelimeler: Henoch Schönlein Purpurası Klinik Bulgular Akut Faz Reaktanları
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Cite This Article
Akalın, F., Çalışkan, S., Sever, L., Mat, C., Tüzüner, N., Oğuz, O., Özdoğan, H., Arısoy, N. (1993). The Relation Between the Clinical Manifestations and Acute Phase Reactants in Children with Henoch Schonlein Purpura. Türk Pediatri Arşivi, Cilt: 28 Sayı: 2. https://ajindex.com/articles/1438105