Hereditary spherocytosis is a congenital disease in which a defect in red cell skeletal protein causes hemolytic anemia hyperbilirubinemia and splenomegaly As maximum transfusion support is necessary during the first year of life recombinant erythropoietin therapy is recommended as an alternative therapy to blood transfusions Here we report 4 infants with hereditary spherocytosis to whom recombinant erythropoietin therapy was administered Key words: hereditary spherocytosis recombinant erythropoietin
📌 3 Key Takeaways
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Objective & Hypothesis:Hereditary spherocytosis is a congenital disease in which a defect in red cell skeletal protein causes hemolytic anemia hyperbilirubinemia and splenomegaly As maximum transfusion support is necessary during the first year of life recombinant erythropoietin therapy is recommended as an alternative therapy to blood transfusions Here we report 4 infants with hereditary spherocytosis to whom recombinant erythropoietin therapy was administered Key words: hereditary spherocytosis recombinant erythropoietin
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Key Findings & Data:Hereditary spherocytosis is a congenital disease in which a defect in red cell skeletal protein causes hemolytic anemia hyperbilirubinemia and splenomegaly As maximum transfusion support is necessary during the first year of life recombinant erythropoietin therapy is recommended as an alternative therapy to blood transfusions Here we report 4 infants with hereditary spherocytosis to whom recombinant erythropoietin therapy was administered Key words: hereditary spherocytosis recombinant erythropoietin
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Conclusion & Impact:Hereditary spherocytosis is a congenital disease in which a defect in red cell skeletal protein causes hemolytic anemia hyperbilirubinemia and splenomegaly As maximum transfusion support is necessary during the first year of life recombinant erythropoietin therapy is recommended as an alternative therapy to blood transfusions Here we report 4 infants with hereditary spherocytosis to whom recombinant erythropoietin therapy was administered Key words: hereditary spherocytosis recombinant erythropoietin
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Hereditary spherocytosis is a congenital disease in which a defect in red cell skeletal protein causes hemolytic anemia hyperbilirubinemia and splenomegaly As maximum transfusion support is necessary during the first year of life recombinant erythropoietin therapy is recommended as an alternative therapy to blood transfusions Here we report 4 infants with hereditary spherocytosis to whom recombinant erythropoietin therapy was administered Key words: hereditary spherocytosis recombinant erythropoietin
Özet
Herediter sferositoz eritrosit membran proteinlerindeki defekt sonucu hemolize eğilimin artması anemi sarılık ve splenomegali ile seyreden kalıtsal bir hastalıktır Transfüzyon ihtiyacının en fazla olduğu ilk bir yıl içinde hastaların artmış eritrosit yıkımını kompanse etmek için yeterli eritropoetin cevabı veremediği gösterildiğinden kan transfüzyonuna alternatif olarak rekombinan eritropoetin tedavisi önerilmektedir Bu yazıda eritropoetin tedavisi uyguladığımız herediter sferositozlu 4 süt çocuğu sunulmaktadır Anahtar Kelimeler: herediter sferositoz rekombinan eritropoetin
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Cite This Article
Celkan, T., Karaman, S., Apak, H., Özkan, A., Soycan, L. Y., Yıldız, İ. (2004). Recombinant erythropoietin treatment in infants with hereditary spherocytosis Original Article. Türk Pediatri Arşivi, Cilt: 39 Sayı: 3. https://ajindex.com/articles/1437787