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Journals / Türk Onkoloji Dergisi / 2026 / Cilt: 21 Sayı: 3

Toxic epidermal necrolysis after cranial radiotherapy and anticonvulsant treatment: a case report

Kraniyal radyoterapi ve antikonvülsan tedavi sonrası gelişen toksik epidermal nekroliz: Olgu sunumu

Ruşen Coşar Alas
Murat Çaloğlu
Vuslet Yürüt Çaloğlu
Mert Saynak
Hakan Karagöl
Zafer Koçak
Cem Uzal
Pages
156–160
Publication Date
2006-04-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We report a case of TEN whit occured in a patient with metastatic non-small cell lung carcinona before whole-brain radiation therapy (WBRT) and then received phenytoin (300 mg day-1).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Toxic epidermal necrolysis (TEN) is rare, but, it has been known life treating reaction.
📊
Key Findings & Data:It's a mucocutaneous reaction resulting from hypersensitivity to a variety of agents including most anticonvulsants.
💡
Conclusion & Impact:We report a case of TEN whit occured in a patient with metastatic non-small cell lung carcinona before whole-brain radiation therapy (WBRT) and then received phenytoin (300 mg day-1).
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:Antikonvülsanlar/yan etki · toksik epidermal nekroliz/sınıflama/etyoloji · Middle Aged

Abstract

Toxic epidermal necrolysis (TEN) is rare, but, it has been known life treating reaction. It's a mucocutaneous reaction resulting from hypersensitivity to a variety of agents including most anticonvulsants. We report a case of TEN whit occured in a patient with metastatic non-small cell lung carcinona before whole-brain radiation therapy (WBRT) and then received phenytoin (300 mg day-1).

Özet

Toksik epidermal nekroliz (TEN), nadir görünen fakat yaşamı tehdit eden bir reaksiyondur. Pek çok ajan tarafından başlatılabilen bir hirpersensitive reaksiyonu olduğu düşünülmektedir. Bu yazıda, metastatik küçük hücreli dışı akciğer kanseri tanısı ile tüm beyin radyoterapisi (TBRT) uygulandıktan sonra Epdantoin (300 mg/gün) başlanan ve 5. günde TEN gelişen bir olgu sunuldu.

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Cite This Article

Alas, R. C., Çaloğlu, M., Çaloğlu, V. Y., Saynak, M., Karagöl, H., Koçak, Z., Uzal, C. (2006). Toxic epidermal necrolysis after cranial radiotherapy and anticonvulsant treatment: a case report. Türk Onkoloji Dergisi, Cilt: 21 Sayı: 3, 156–160. https://ajindex.com/articles/1437215

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