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Journals / Türk Onkoloji Dergisi / 2026 / Cilt: 24 Sayı: 2

The importance of pretreatment performance status and LDH level in patients with stage III-IV nasopharyngeal carcinoma

Evre III-IV nazofarinks kanseri tanılı hastalarda tedavi öncesi performans durumu ve LDH düzeyinin önemi

Vuslat Yürüt-çaloğlu
Murat Çaloğlu
Hakan Karagöl
Ruşen Coşar-alas
Zafer Koçak
Pages
65–72
Publication Date
2009-03-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Gender (p=0.022), Eastern Cooperative Oncology Group (ECOG) performance status (PS) (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:OBJECTIVES To evaluate the prognostic factors in patients treated with radiotherapy for locally advanced nasopharyngeal carcinoma.
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Key Findings & Data:METHODS Forty-eight patients (37 males, 11 females) treated between September 1999 and September 2007 were assessed retrospectively.
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Conclusion & Impact:Gender (p=0.022), Eastern Cooperative Oncology Group (ECOG) performance status (PS) (p
🔬Design:Makale
📍Scope:2007 Verileri
⚙️Variables:LDH düzeyi · nazofarinks kanseri · performansdurumu

Abstract

OBJECTIVES To evaluate the prognostic factors in patients treated with radiotherapy for locally advanced nasopharyngeal carcinoma. METHODS Forty-eight patients (37 males, 11 females) treated between September 1999 and September 2007 were assessed retrospectively. RESULTS Ten patients (21%) recurred loco-regionally. Gender (p=0.022), Eastern Cooperative Oncology Group (ECOG) performance status (PS) (p

Özet

AMAÇ Radyoterapi ile tedavi edilen evre III-IV nazofarinks kanserli hastalarda prognostik faktörler incelendi. GEREÇ VE YÖNTEM Eylül 1999-Eylül 2007 tarihleri arasında tedavi edilen 48 hasta (37 erkek, 11 kadın) geriye dönük olarak değerlendirildi. BULGULAR Lokal-bölgesel yineleme 10 (%21) hastada izlendi. Lokal-bölgesel kontrolü etkileyen faktörler; cinsiyet (p=0.022), Eastern Cooperative Oncology Group (ECOG) performans durumu (p < 0.0001), Hb (p=0.0035) ve LDH düzeyidir (p=0.032). Multivariet analizde, sadece performans durumu etkisini korumuştur (p=0.003). On sekiz (%38) hastada uzak metastaz gelişti. Univariet analizde performans durumu (p=0.022), Hb (p=0.002), ALP (p=0.004), LDH düzeyi (p=0.007) ve RT’yi tamamlama (p=0.014) uzak metastaz oluşmasını etkiledi. Multivariet analizde ise sadece LDH düzeyi (p=0.001) etkinliğini korudu. Analiz sırasında 27 (%56) hastan›n hayatını kaybettiği saptandı. Univariet analizde performans durumu (p=0.012), RT’yi tamamlama (p < 0.0001), metastaz oluşması (p=0.018) ve LDH düzeyinin (p=0.018) sağkalımı etkildiği görüldü. Multivariet analizde yalnızca LDH düzeyi anlamlılığını korudu (p=0.026).

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Cite This Article

Yürüt-çaloğlu, V., Çaloğlu, M., Karagöl, H., Coşar-alas, R., Koçak, Z. (2009). The importance of pretreatment performance status and LDH level in patients with stage III-IV nasopharyngeal carcinoma. Türk Onkoloji Dergisi, Cilt: 24 Sayı: 2, 65–72. https://ajindex.com/articles/1437133

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